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Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

As the COVID-19 pandemic progresses with little prospect of immediate relief, a recent study by Johns Hopkins University researchers published on the preprint server medRxiv* in October 2020 discusses the association of Immunoglobulin M (IgM) autoantibodies against the host receptor that binds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with severe disease via vascular endothelial damage. This could help develop better therapies and prognostic criteria.

19 Oct 2020

Hydrogels and magnetic field could be used to rebuild complex body tissues

Using a magnetic field and hydrogels, a team of researchers in the Perelman School of Medicine at the University of Pennsylvania have demonstrated a new possible way to rebuild complex body tissues, which could result in more lasting fixes to common injuries, such as cartilage degeneration.

19 Oct 2020

Three new research teams aim to improve therapies for difficult-to-treat pediatric cancers

While incredible progress has been made in advancing pediatric cancer research, critical unmet needs still exist, especially for more aggressive cancers such as neuroblastomas and Ewing sarcoma.

19 Oct 2020

Researchers describe how to assess if an antibiotic has a new mechanism of action

The fight against bacterial infections, especially those caused by resistant pathogens, is in full swing with the search for new antibiotic agents.

19 Oct 2020

Cytotoxic NK cells also have immunological memory function

Good news for the human immune system: researchers from MedUni Vienna's Departments of Dermatology and Surgery have managed to ascribe an immunological memory function to a subset of cytotoxic NK cells, which have hitherto been regarded as antigen-non-specific.

19 Oct 2020

Biogelx has achieved ISO9001:2015 certification for Quality Management Systems

Biogelx is a Scottish biomaterials company specializing in the development of non-animal derived materials for 3D cell culture and bioprinting applications.

19 Oct 2020

CBD could reduce lung damage caused by COVID-19

One way CBD appears to reduce the "cytokine storm" that damages the lungs and kills many patients with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this storm.

19 Oct 2020

Even healthy people have "autoreactive" T cells linked to type 1 diabetes, shows study

Your pancreas is studded with cell clusters called islets. In most people, special beta cells live snug in the islets, happily making the insulin that the body uses to regulate blood sugar.

19 Oct 2020

New device rapidly transfers delicate tissue or electronic sheets to patients

Thin tissue grafts and flexible electronics have a host of applications for wound healing, regenerative medicine and biosensing.

19 Oct 2020

Concerti algorithm identifies intra-patient heteroplasmies in SARS-CoV-2 patients

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that emerged in Wuhan, China, in late 2019 has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, which has affected more than 39.8 million lives globally and claimed over 1.11 million deaths to date.

18 Oct 2020

Comparative analysis reveals common vulnerabilities across coronaviruses

Three lethal human respiratory syndromes associated with coronavirus (CoV) infections have emerged in the past two decades. They are severe acute respiratory syndrome (SARS) in 2002, Middle East respiratory syndrome (MERS) in 2012, and coronavirus disease 2019 (COVID-19) in 2019.

18 Oct 2020

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

Researchers studying young obese mice found that expression of ACE2, a receptor in host cells that binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is higher in the lungs and trachea of obese mice. The finding could partly explain why obesity is a high-risk factor for COVID-19.

18 Oct 2020

Cell News and Research

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

Hydrogels and magnetic field could be used to rebuild complex body tissues

Three new research teams aim to improve therapies for difficult-to-treat pediatric cancers

Researchers describe how to assess if an antibiotic has a new mechanism of action

Cytotoxic NK cells also have immunological memory function

Biogelx has achieved ISO9001:2015 certification for Quality Management Systems

CBD could reduce lung damage caused by COVID-19

Even healthy people have "autoreactive" T cells linked to type 1 diabetes, shows study

New device rapidly transfers delicate tissue or electronic sheets to patients

Concerti algorithm identifies intra-patient heteroplasmies in SARS-CoV-2 patients

Comparative analysis reveals common vulnerabilities across coronaviruses

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

New tool can provide non-invasive decision support for NSCLC treatment

NAM announces winners of the inaugural round of Healthy Longevity Catalyst Awards

Nanoparticles release bursts of calcium to reverse multidrug resistance in tumor cells

Combination of peptides and antibiotics could be key to eliminating Leishmania parasites

Antispastic drug candidate could offer new hope for millions of patients suffering from spasticity

Researchers report the discovery of innate immune signaling pathway in fibroblasts

NIH launches adaptive Phase 3 clinical trial to test immune modulator drugs in COVID-19 patients

Researchers aim to identify disease tolerance mechanisms in sepsis patients

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