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Patent issued for generating genetically evolved mammalian cells through the regulation of mismatch repair

Morphotek announced today the issuance of United States Patent 6,825,038 covering the regulation of mismatch repair (MMR), a powerful process for generating functional diversity in mammalian cells, to yield sibs exhibiting desirable phenotypes for target discovery, drug screening and/or product development.

13 Dec 2004

FDA accepts Genmab's Investigational New Drug Application for active rheumatoid arthritis treatment

Genmab announced today the US Food and Drug Administration (FDA) accepted its Investigational New Drug Application (IND) to start a Phase I/II dose escalation trial for HuMax-CD20 to treat patients with active rheumatoid arthritis (RA) who have failed one treatment with one or more disease modifying anti-rheumatic drugs (DMARDs).

13 Dec 2004

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

The first detailed structure of a botulism toxin attached to its target protein reveals that the toxin snakes the protein around itself — a sort of “reverse anaconda” — to recognize the receptor.

13 Dec 2004

Newly discovered genetic defect might represent an important risk factor for major depression

A newly discovered genetic defect might represent an important risk factor for major depression, a condition which effects 20 million people in the U.S., according to Duke University Medical Center researchers.

13 Dec 2004

Lupus drug may also be useful in treating psoriasis

A new drug candidate previously shown to reduce harmful side effects of the autoimmune disease lupus also may be useful in treating psoriasis.

13 Dec 2004

Model may explain how alcohol stimulates tumor growth

The investigators found that compared to the saline control group, the embryos exposed to ethanol experienced increases in tumor size, tumor blood vessel density, cancer cell infiltration of blood vessels, and VEGF levels.

13 Dec 2004

Discovery of key immune system molecules that helps determine how effectively a person resists HIV infection

A team of researchers based partly in South Africa has identified a key set of immune system molecules that helps determine how effectively a person resists infection with human immunodeficiency virus (HIV).

8 Dec 2004

Wide angle X-ray scattering (WAXS) could help produce lead drugs for disease therapy

Structural changes in proteins can now be seen in increased detail, using a new application of an existing technique. The application, developed at the U.S. Department of Energy's Argonne National Laboratory, could help produce lead drugs for disease therapy.

8 Dec 2004

New technology will advance our understanding of role of complex sugar chains decorating the surface of cells in the body

An international consortium of scientists lead by Dr. James Paulson of The Scripps Research Institute has created a technology that will advance our understanding of the role of complex sugar chains (glycans or carbohydrates) that decorate the surface of cells in the body.

8 Dec 2004

Trimming fat overcomes one of the major obstacles to drug design

Biochemists at Ohio State University and their colleagues have overcome one of the major obstacles to drug design, by trimming some of the fat from a molecular sponge that scientists use to study proteins.

8 Dec 2004

New research is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA

"All cancers are marked by some form of DNA replication gone awry, so a basic understanding of DNA replication is of paramount importance to those designing cancer-fighting drugs,"

8 Dec 2004

Resveratrol antioxidant found in red wine may benefit heart tissue

New research on rat heart cells suggests that a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis.

8 Dec 2004

Defect in one of nature's oldest proteins may be an underlying cause in human miscarriages

University of Rochester scientists studying a vital protein called Serum Response Factor (SRF) in mice have learned new and unexpected facts about SRF's role in early cardiovascular development, and how a defect in this gene may be an underlying cause in human miscarriages.

8 Dec 2004

Thiazolidinedione (TZD) class of anti-diabetic drugs may be a potential targeted therapy for myeloma patients

In laboratory tests on multiple myeloma cells, University of Rochester researchers found that this type of cancer expresses a protein that makes it an easy target for an existing class of diabetes drugs. After more investigation, they hope the discovery will lead to a new, targeted therapy for myeloma patients.

8 Dec 2004

Transplanted bone marrow cells reduce liver fibrosis in mice

Transplanted bone marrow cells can reduce carbon tetrachloride-induced liver fibrosis in mice and significantly improve their survival rates, according to a new study

8 Dec 2004

Revlimid clinical data in newly diagnosed multiple myeloma presented

Celgene Corporation announced today that data evaluating clinical results on Revlimid (lenalidomide) as a new therapeutic approach for patients with newly diagnosed multiple myeloma (MM) was presented at the American Society of Hematology 46th Annual Meeting in San Diego.

7 Dec 2004

Study looks at muscle repair and resilience

Healthy military personnel and muscular dystrophy patients are at opposite ends of the spectrum when is comes to muscle strength and resilience. However, a new University of Iowa study may provide insights that improve muscle health for both these groups.

7 Dec 2004

New clues in understanding why group A streptococci (GAS) has a range of bacterial afflictions in humans

Researchers have unlocked new clues in understanding why group A streptococci (GAS) has a range of bacterial afflictions in humans. One of the keys to this species of bacteria is its production of streptokinase (SK), an enzyme that activates plasminogen, the blood clot-dissolving protein in humans.

6 Dec 2004

Thalidomide shows promise in fighting myeloma

Thalidomide, a drug often used to treat symptoms of leprosy and in testing to fight HIV, is now demonstrating activity in fighting a common cancer that occurs in bone marrow, myeloma.

6 Dec 2004

New advances in sickle cell disease

Excruciating pain episodes, recurrent pneumonias, strokes, severe infections, chronic hemolytic anemia, and secondary pulmonary hypertension are common complications of sickle cell disease, a life-threatening inherited defect in blood that causes normally disc-shaped red blood cells to take on a sickle shape.

6 Dec 2004

G Protein News and Research

Patent issued for generating genetically evolved mammalian cells through the regulation of mismatch repair

FDA accepts Genmab's Investigational New Drug Application for active rheumatoid arthritis treatment

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

Newly discovered genetic defect might represent an important risk factor for major depression

Lupus drug may also be useful in treating psoriasis

Model may explain how alcohol stimulates tumor growth

Discovery of key immune system molecules that helps determine how effectively a person resists HIV infection

Wide angle X-ray scattering (WAXS) could help produce lead drugs for disease therapy

New technology will advance our understanding of role of complex sugar chains decorating the surface of cells in the body

Trimming fat overcomes one of the major obstacles to drug design

New research is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA

Resveratrol antioxidant found in red wine may benefit heart tissue

Defect in one of nature's oldest proteins may be an underlying cause in human miscarriages

Thiazolidinedione (TZD) class of anti-diabetic drugs may be a potential targeted therapy for myeloma patients

Transplanted bone marrow cells reduce liver fibrosis in mice

Revlimid clinical data in newly diagnosed multiple myeloma presented

Study looks at muscle repair and resilience

New clues in understanding why group A streptococci (GAS) has a range of bacterial afflictions in humans

Thalidomide shows promise in fighting myeloma

New advances in sickle cell disease

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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