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Important genetic risk factor for amyotrophic lateral sclerosis

Two Hershey, Pa., researchers were part of a team that has uncovered what may be an important genetic risk factor for amyotrophic lateral sclerosis (ALS).

6 Dec 2004

Scientist develops way to deliver promising genetic tool into living cells

By exploiting an HIV protein that readily traverses cell membranes, Carnegie Mellon University scientists have developed a new way to introduce a gene-like molecule called a peptide nucleic acid (PNA) directly into live mammalian cells, including human embryonic stem (ES) cells.

6 Dec 2004

Common ingredient in some shampoos (methylisothiazolinone) stunts developing neurons of rats

An antimicrobial agent found in some shampoos and hand creams and widely used in industrial settings inhibits the development of particular neuron structures that are essential for transmitting signals between cells.

6 Dec 2004

First live imaging of specialized immune system cells reveals new clues about body’s security system

To keep the body safe, the immune system enlists more than one form of protection. A circulating task force of immune system cells monitors the body’s periphery, and sends information back to field command centers — the lymph nodes — located at pivotal traffic points.

6 Dec 2004

Alliance to develop and commercialize fully-human anti-anthrax antibody

MDX-1303 was developed by Medarex using its UltiMAb Human Antibody Development System, and this antibody is currently in preclinical development by Medarex for use against human anthrax infection.

6 Dec 2004

Study shows long-term benefits for chronic myeloid leukemia patients receiving therapy with imatinib

CHU in Poitiers, France, yesterday announced results of a study showing that newly diagnosed patients with a certain form of leukemia who are treated early with imatinib are more likely to achieve complete cytogenetic responses (the elimination of leukemic cells, a major goal of therapy) and have improved long-term outcomes.

6 Dec 2004

New drug can successfully treat patients who have become resistant to Gleevec

A team of prominent researchers led by Charles Sawyers, M.D. and Moshe Talpaz, M.D., presented compelling clinical findings today showing that a new drug, BMS-354825, can successfully treat patients who have become resistant to Gleevec (the frontline therapy for chronic myelogenous leukemia, CML).

5 Dec 2004

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Bcl-6 oncogene - genetic target for lymphoma treatment

Results from a pre-clinical study show that the gene designated Bcl-6 is an oncogene -- that is, one with the potential to cause a normal cell to become cancerous -- but that certain peptide inhibitors can in effect inactivate it, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Genasense shown to enhance the anti-lymphoma activity of Velcade and Rituxan

Genta Incorporated announced that two new studies have shown that Genasense (oblimersen sodium) Injection, the Company's lead anticancer drug, showed synergistic activity with both bortezomib (Velcade; Millennium Pharmaceuticals, Inc.) and rituximab (Rituxan; Genentech, Idec) in experimental models of B-cell non-Hodgkin's lymphoma (NHL).

5 Dec 2004

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Cell biologists are of two minds about the possible biological effects of mobile phone radiation. In the mid-1990s, studies describing possible pathological effects on tissues bombarded with low-level radio frequencies (RF) were first featured in the popular press and then discredited by scientists.

4 Dec 2004

Autophagy is also cell's second line of defense against invading pathogens such as strep

Cells give up their secrets slowly. Just when you think that all major cellular systems are understood, along comes a surprise. The latest is about autophagy, a major pathway for degrading and recycling within cells.

4 Dec 2004

Temperature sensing protein implicated in mediating thermotaxis

The songwriter Noel Coward once declared that only mad dogs and Englishmen went out in the midday sun. MIT biologists Mark Rosenzweig, Paul Garrity and their colleagues now have a third candidate for the lyric—fruit flies with defects in a gene called dTrpA1.

4 Dec 2004

A gallery of highly-specific, gene and protein “mug shots” of cancer types would be a powerful for oncologists

Doctors would like to diagnose malignancies rapidly by matching them with highly-specific genetic “mug shots” based on the presence of characteristic mRNAs or proteins. This kind of specificity would facilitate screening and early detection, and would potentially allow targeted treatments specific to each type of cancer

4 Dec 2004

Phase 3 results of Genasense plus Dexamethasone in patients with advanced multiple myeloma

Genta Incorporated announced that results from the Company's randomized Phase 3 clinical trial of Genasense(R) (oblimersen sodium) Injection in patients with relapsed or refractory multiple myeloma were presented today at the annual meeting of the American Society of Hematology (ASH) in San Diego, CA.

4 Dec 2004

Heart researchers have used gene therapy to bring failing rat hearts back to normal

Scientists led by Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine in Jefferson Medical College of Thomas Jefferson University in Philadelphia, used a virus to insert the gene for a protein called S100A1 into failing rat hearts.

4 Dec 2004

G Protein News and Research

Important genetic risk factor for amyotrophic lateral sclerosis

Scientist develops way to deliver promising genetic tool into living cells

Common ingredient in some shampoos (methylisothiazolinone) stunts developing neurons of rats

First live imaging of specialized immune system cells reveals new clues about body’s security system

Alliance to develop and commercialize fully-human anti-anthrax antibody

Study shows long-term benefits for chronic myeloid leukemia patients receiving therapy with imatinib

New drug can successfully treat patients who have become resistant to Gleevec

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Bcl-6 oncogene - genetic target for lymphoma treatment

Genasense shown to enhance the anti-lymphoma activity of Velcade and Rituxan

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Autophagy is also cell's second line of defense against invading pathogens such as strep

Temperature sensing protein implicated in mediating thermotaxis

A gallery of highly-specific, gene and protein “mug shots” of cancer types would be a powerful for oncologists

Phase 3 results of Genasense plus Dexamethasone in patients with advanced multiple myeloma

Heart researchers have used gene therapy to bring failing rat hearts back to normal

Fossil record of the human immune system reveals antibodies that block cancer metastasis

Gene decoding revealed at atomic level

Red meat consumption is an independent risk factor in the development of inflammatory arthritis

Cancer Research Technology grants AstraZeneca an exclusive license to a key patent

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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