Protein C News and Research

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Study findings suggest how progranulin deficiency causes frontotemporal dementia

In a recent study in Human Molecular Genetics, researchers from VIB and KU Leuven led by prof. Philip Van Damme, reveal a novel function for progranulin in lysosomes: it acts as chaperone of the lysosomal protease cathepsin D. The results were obtained in collaboration with Prof. Paul Saftig from the University of Kiel.

8 May 2017

Choice of fat causes distinct epigenetic changes in human adipose tissue, study shows

Previous research has demonstrated that saturated fat is more fattening and less muscle building than polyunsaturated fats. A new study shows that the choice of fat causes epigenetic changes which in turn could contribute to differences in fat storage.

8 May 2017

Study uncovers potential new therapeutic targets for HCV infections

An international study led by researchers at Monash University' Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.

8 May 2017

Machine learning algorithm can help predict progression of age-related macular degeneration

Scientists have demonstrated that a machine learning algorithm, using images of patients' retinas obtained over time, can predict the critical moment when early or intermediate age-related macular degeneration (AMD) will progress into severe AMD.

8 May 2017

Obese women may get less dangerous form of preeclampsia, study suggests

Despite having higher rates of preeclampsia, a dangerous high-blood pressure disorder of late pregnancy, obese women may be less than half as likely to suffer strokes, seizures, and other serious complications of the disorder. The

5 May 2017

Study shows how influenza A hijacks human cellular machinery to replicate

Much is known about flu viruses, but little is understood about how they reproduce inside human host cells, spreading infection. Now, a research team headed by investigators from the Icahn School of Medicine at Mount Sinai is the first to identify a mechanism by which influenza A, a family of pathogens that includes the most deadly strains of flu worldwide, hijacks cellular machinery to replicate.

5 May 2017

FDA approves new AML drug after clinical testing at Dana-Farber

A targeted drug whose clinical testing was led by Richard Stone, MD, of Dana-Farber Cancer Institute, has become the first new treatment for newly diagnosed acute myeloid leukemia (AML) in more than 25 years.

5 May 2017

Researchers pinpoint gene that plays crucial role in formation of neural tube defects

Researchers have identified a gene that plays a key role in the formation of neural tube defects, a problem commonly found in infants of pregnant women with diabetes.

5 May 2017

Researchers discover new defense mechanism against bacteria during wound healing

Researchers in dermatology at Lund University in Sweden believe they have cracked the mystery of why we are able to quickly prevent an infection from spreading uncontrollably in the body during wounding. They believe this knowledge may be of clinical significance for developing new ways to counteract bacteria.

5 May 2017

Scientists identify RIOK1 enzyme as new target for cancer therapy

Dr. Florian Weinberg, from Prof. Dr. Tilman Brummer's research group at the Institute of Molecular Medicine and Cell Research of the University of Freiburg, joined forces with scientists from the Departments of Clinical Pathology and Medicine I of the University Medical Centre Freiburg and the Kinghorn Cancer Centre/Garvan Insitute in Australia in an international team that has identified a new target for cancer therapy.

5 May 2017

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

Recurrence of head and neck squamous cell carcinoma (HNSCC) negative for human papillomavirus (HPV) following radiation therapy was associated with high tumor levels of the protein PD-L1.

5 May 2017

TSRI scientists uncover regulatory machinery underlying the function of cancer protein

Despite intense research, there's been much confusion regarding the exact role of a protein in a critical cancer-linked pathway. On one hand, the protein is described as a cell proliferation inhibitor, on the other, a cell proliferation activator, a duality that has caused a great deal of scientific head scratching.

5 May 2017

Study sheds light on neural mechanisms of Fragile X syndrome

A collaboration between scientists in Belgium, the United States, Norway, France and the UK has resulted in a study that sheds light on the neural mechanisms of Fragile X syndrome.

5 May 2017

Study reveals critical role of omega-3 fatty acids in preserving integrity of the blood-brain barrier

Already extolled for their health benefits as a food compound, omega-3 fatty acids now appear to also play a critical role in preserving the integrity of the blood-brain barrier, which protects the central nervous system from blood-borne bacteria, toxins and other pathogens, according to new research from Harvard Medical School.

5 May 2017

Easing cellular traffic jams in Huntington’s disease may save brain cells

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center - the nucleus- appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

5 May 2017

Genetic study outlines path to personalize breast cancer risk assessment and treatment

Although the odds of developing breast cancer are nearly identical for black and white women, black women are 42 percent more likely to die from the disease. This mortality gap – driven by social and environmental, as well as biological factors – continues to persist.

4 May 2017

New synthetic retina could offer new hope to visually impaired people

A synthetic, soft tissue retina developed by an Oxford University student could offer fresh hope to visually impaired people.

4 May 2017

Researchers develop hybrid nanomaterial for destruction of cancer cells

Most tumors contain regions of low oxygen concentration where cancer therapies based on the action of reactive oxygen species are ineffective.

4 May 2017

Scientists uncover thousands of human genes that are expressed differently in the two sexes

Men and women differ in obvious and less obvious ways -- for example, in the prevalence of certain diseases or reactions to drugs. How are these connected to one's sex? Weizmann Institute of Science researchers recently uncovered thousands of human genes that are expressed -- copied out to make proteins -- differently in the two sexes.

4 May 2017

$New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds$

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

A team of researchers of the University of Barcelona and the Hospital del Mar Medical Research Institute have discovered a new mutation that has an impact on the bone so that it is vulnerable to the bisphosphonate, a drug used to treat osteoporosis.

4 May 2017

Protein C News and Research

Study findings suggest how progranulin deficiency causes frontotemporal dementia

Choice of fat causes distinct epigenetic changes in human adipose tissue, study shows

Study uncovers potential new therapeutic targets for HCV infections

Machine learning algorithm can help predict progression of age-related macular degeneration

Obese women may get less dangerous form of preeclampsia, study suggests

Study shows how influenza A hijacks human cellular machinery to replicate

FDA approves new AML drug after clinical testing at Dana-Farber

Researchers pinpoint gene that plays crucial role in formation of neural tube defects

Researchers discover new defense mechanism against bacteria during wound healing

Scientists identify RIOK1 enzyme as new target for cancer therapy

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

TSRI scientists uncover regulatory machinery underlying the function of cancer protein

Study sheds light on neural mechanisms of Fragile X syndrome

Study reveals critical role of omega-3 fatty acids in preserving integrity of the blood-brain barrier

Easing cellular traffic jams in Huntington’s disease may save brain cells

Genetic study outlines path to personalize breast cancer risk assessment and treatment

New synthetic retina could offer new hope to visually impaired people

Researchers develop hybrid nanomaterial for destruction of cancer cells

Scientists uncover thousands of human genes that are expressed differently in the two sexes

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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