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Researchers identify a type of immune cell that drives chronic organ transplant failure

University of Pittsburgh researchers have identified a type of immune cell that drives chronic organ transplant failure in a mouse model of kidney transplantation and uncovered pathways that could be therapeutically targeted to improve patient outcomes.

21 Apr 2023

U-M to launch a population-based study on Alzheimer’s disease and related dementias in India

The University of Michigan is looking to launch a population-based study on Alzheimer’s disease and related dementias in India.

21 Apr 2023

Gestational obesity plus zika virus infection can compromise placenta’s immune response

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that gestational obesity associated with infection by zika virus influences the placenta's antiviral response, weakening the organ's capacity to attack the pathogen and protect the fetus.

20 Apr 2023

Mouse studies can help find better therapeutic targets for people with PCOS

Polycystic ovarian syndrome, or PCOS, can cause a range of symptoms, including disrupted menstrual cycles, abdominal obesity, cardiovascular disease, and type 2 diabetes.

18 Apr 2023

Researchers receive $4.1 million grant to identify factors linked to high rates of type 2 diabetes in children

Type 2 diabetes (T2D) is surging among U.S. children. The number of youths under 20 years old living with the disease has nearly doubled between 2001 and 2017, and yet—aside from increases in childhood obesity—the reasons for this disturbing increase are not clear.

18 Apr 2023

U-M researcher launches new project to identify the full range of RNA building blocks inside human cells

University of Michigan pediatric neurologist Vivian Cheung is launching an international project to identify the full range of RNA building blocks inside human cells.

18 Apr 2023

Many top-selling brand-name drugs in Medicare may provide little added therapeutic benefit

Brand-name drugs cost two to three times more in the U.S. than in other countries, but many of the top-selling brand name drugs may provide little added therapeutic benefit.

18 Apr 2023

New AI tool accurately predicts aggressiveness of colorectal cancer

A new artificial intelligence model designed by researchers at Harvard Medical School and National Cheng Kung University in Taiwan could bring much-needed clarity to doctors delivering prognoses and deciding on treatments for patients with colorectal cancer, the second deadliest cancer worldwide.

13 Apr 2023

Curtin researchers identify the genetic signature of pre-malignant liver cells

Researchers at Curtin University have identified the genetic signature of pre-malignant liver cells, offering potentially significant implications for the almost 3,000 Australians diagnosed with the deadly cancer each year.

13 Apr 2023

Genomic study reveals Babesia duncani's pathogenicity and virulence

'Tis the season for hiking now that spring has arrived and temperatures are on the upswing. But with hikes come insect bites and on the increase in North America is babesiosis, a malaria-like disease spread especially between May and October by a tick.

13 Apr 2023

New treatment pathway identified for patients with idiopathic nephrotic syndrome

With funding from charity Kidney Research UK, Dr Carl May from Bristol Medical School and his team have identified a new treatment pathway for patients with non-genetic (idiopathic) nephrotic syndrome (INS), targeting a still unknown factor that causes the progression towards kidney failure.

13 Apr 2023

Placebo in addition to methadone shown to be feasible treatment for opioid use disorder

There were more than 100,000 reported deaths from opioid overdoses in 2021, according to the Centers for Disease Control and Prevention.

12 Apr 2023

Exploring the tantalizing questions about sleep

Sleep is one of the most essential human activities - so essential, in fact, that if we don't get enough sleep for even one night, we may struggle to think, react, and otherwise make it through the day.

11 Apr 2023

U-M awarded a new seven-year, $71M Clinical and Translational Science Award

Traditionally, the timeline for translating research into effective therapies for disease has been long. On average, it takes more than 10 years to bring a potential medication to market, and most drugs and other interventions that reach clinical trials fail to produce any benefit for patients.

10 Apr 2023

Novel amino acid compound treats nonalcoholic fatty liver disease in non-human primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates - bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

10 Apr 2023

Bariatric surgery may be an effective treatment for obese people at risk of diabetes, peripheral neuropathy

For more than 100 million Americans who are obese, bariatric surgery may reverse complications related to diabetes, including regenerating damaged nerves, a Michigan Medicine study shows.

10 Apr 2023

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Inflammatory bowel disease, or IBD, describes Crohn's disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder - a condition in which the body's immune system attacks healthy tissues.

7 Apr 2023

Discovery may change the way people think about immune strategies

The human body is capable of creating a vast, diverse repertoire of antibodies - the Y-shaped sniffer dogs of the immune system that can find and flag foreign invaders.

7 Apr 2023

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Fasting diet could be the key to reducing the risk of type 2 diabetes

A fasting diet which focuses on eating early in the day could be the key to reducing the risk of developing type 2 diabetes.

6 Apr 2023

Medical School News and Research

Researchers identify a type of immune cell that drives chronic organ transplant failure

U-M to launch a population-based study on Alzheimer’s disease and related dementias in India

Gestational obesity plus zika virus infection can compromise placenta’s immune response

Mouse studies can help find better therapeutic targets for people with PCOS

Researchers receive $4.1 million grant to identify factors linked to high rates of type 2 diabetes in children

U-M researcher launches new project to identify the full range of RNA building blocks inside human cells

Many top-selling brand-name drugs in Medicare may provide little added therapeutic benefit

New AI tool accurately predicts aggressiveness of colorectal cancer

Curtin researchers identify the genetic signature of pre-malignant liver cells

Genomic study reveals Babesia duncani's pathogenicity and virulence

New treatment pathway identified for patients with idiopathic nephrotic syndrome

Placebo in addition to methadone shown to be feasible treatment for opioid use disorder

Exploring the tantalizing questions about sleep

U-M awarded a new seven-year, $71M Clinical and Translational Science Award

Novel amino acid compound treats nonalcoholic fatty liver disease in non-human primates

Bariatric surgery may be an effective treatment for obese people at risk of diabetes, peripheral neuropathy

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Discovery may change the way people think about immune strategies

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

Fasting diet could be the key to reducing the risk of type 2 diabetes

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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