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Polyamines reshape protein phosphorylation to guide key cellular fate decisions

Polyamines are small molecules naturally present in all cells and are critical in guiding cellular decisions, whereas an alteration in the abundance of these metabolites is invariably observed in pathological scenarios such as cancer or aging.

14 Jan 2026

Pancreatic organoid study reveals key factors shaping complex lumen formation

Organs often have fluid-filled spaces called lumens, which are crucial for organ function and serve as transport and delivery networks.

9 Jan 2026

Novel cell division mechanism discovered in early embryonic development

Cell division is an essential process for all life on earth, yet the exact mechanisms by which cells divide during early embryonic development have remained elusive – particularly for egg-laying species.

8 Jan 2026

Reprogramming immunity to protect beta cells in type 1 diabetes

In the battle against type 1 diabetes (T1D), one researcher at the Medical University of South Carolina (MUSC) is leading a bold new front. With $1 million in funding from Breakthrough T1D, the leading global T1D research and advocacy organization, Leonardo Ferreira, Ph.D., assistant professor of Pharmacology and Immunology, and his collaborators at partnering institutions will explore a new approach to treating – and potentially curing – the disease.

7 Jan 2026

Replenishing mitochondria significantly reduces chronic nerve pain, research shows

For millions living with nerve pain, even a light touch can feel unbearable. Scientists have long suspected that damaged nerve cells falter because their energy factories known as mitochondria don't function properly.

7 Jan 2026

TAAR1 mutation impairs brain signaling in schizophrenia

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely silence a brain receptor that pharmaceutical companies are racing to target with new drugs.

6 Jan 2026

Epigenetic plasticity in germinal center B cells may help explain lymphoma origins

Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During their preparation for this battle, B cells transiently revert to a more flexible, or plastic, stem-cell-like state in the lymph nodes, according to a new preclinical study from Weill Cornell Medicine investigators.

30 Dec 2025

Calcium signaling helps maintain protein quality in the endoplasmic reticulum

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, is widely unknown.

26 Dec 2025

Reframing the role of MCL1 in cancer signaling and metabolism

A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides fundamental insights into cancer biology.

22 Dec 2025

New research reveals a hidden source of cellular bioelectricity

Many biological processes are regulated by electricity-from nerve impulses to heartbeats to the movement of molecules in and out of cells.

19 Dec 2025

Autophagy steers T cell fate during immune division

Researchers at the Max Delbrück Center have found that a cellular housekeeping mechanism called autophagy plays a major role in ensuring that T stem cells undergo normal cell division.

19 Dec 2025

Combination therapy shows promise to treat a rare, catastrophic pediatric brain cancer

St. Jude Children's Research Hospital scientists identified a promising combination approach to treat a rare, but catastrophic pediatric brain cancer called atypical teratoid rhabdoid tumor (ATRT).

16 Dec 2025

Human heart organoids enable new therapies for atrial fibrillation

Though an estimated 60 million people around the world have atrial fibrillation, or A-fib, a type of irregular and often fast heartbeat, it's been at least 30 years since any new treatments have been developed.

12 Dec 2025

Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation.

12 Dec 2025

JAX wins $30 million contract to create computational "digital twins" of the human heart

Developing new drugs is one of the riskiest and most expensive endeavors in science. Today, The Jackson Laboratory (JAX) announced a bold initiative to improve that trajectory, powered by an up to $30 million contract from the Advanced Research Projects Agency for Health (ARPA-H) Computational ADME-Tox and Physiology Analysis for Safer Therapeutics (CATALYST) program.

8 Dec 2025

Understanding how adult brains adapt to challenge and change

In a revelatory Genomic Press Interview published today in Brain Medicine, Dr. Paul Lucassen, full professor at the University of Amsterdam and leader of the Brain Plasticity group, shares his scientific journey that helped transform our understanding of how adult brains adapt to challenge and change.

4 Dec 2025

Neural stem cells drive lifelong eye growth in marine bristleworms

A new study, led by the University of Vienna and the Alfred Wegener Institute in Bremerhaven, shows how the eyes of adult marine bristleworms continue to grow throughout life – driven by a ring of neural stem cells reminiscent of vertebrate eyes.

1 Dec 2025

Study reveals ATM kinase as the key driver of replicative senescence

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective caps at the chromosome ends-those caps eventually become too short to prevent chromosome ends from being recognized as DNA breaks.

1 Dec 2025

Blocking a ‘gerozyme’ reverses cartilage loss in mice

An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee joints of old mice, a Stanford Medicine-led study has found.

28 Nov 2025

Uncovering the hidden metabolic effects of soybean oil

Soybean oil, the most widely consumed cooking oil in the United States and a staple of processed foods, contributes to obesity, at least in mice, through a mechanism scientists are now beginning to understand.

27 Nov 2025