Small Intestine News and Research

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The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Researchers elucidated the mechanisms of long-term T lymphocyte lodgement in tissues other than lymphoid tissues and the reasons for the transient residency of specific subsets of tissue-resident memory T (TRM) lymphocytes.

14 Dec 2022

Biobattery researchers have a solution for the hard-to-reach small intestine

Tech companies have developed many devices that work outside the body, such as cell phones, smart watches, tablets and hundreds of others. Inside the body, though? That's obviously trickier for several reasons, but power for a device is a big one.

12 Dec 2022

Researchers develop a self-powered ingestible sensor system to monitor intestinal metabolites

Engineering researchers have developed a battery-free, pill-shaped ingestible biosensing system designed to provide continuous monitoring in the intestinal environment.

1 Dec 2022

Harmful gut bacteria co-opt a genetic susceptibility to trigger Crohn’s disease

Changes in a single gene open the door for harmful gut bacteria to set off the inflammation that drives Crohn’s disease, according to a new study led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

1 Dec 2022

SARS-CoV-2 can cause hyperglycemia in cats

In a recent study published in The Journal of Infectious Diseases, researchers explored the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia in cats.

30 Nov 2022

Gut microbial flavonoid catabolite reverses fatty liver disease in mice

Researchers report that a gut microbial catabolite could reduce the cardiometabolic disease burden in mice.

29 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Researchers study the unique adaptability of small intestinal bacteria for the first time

Bacteria in the small intestine adapt dynamically to our nutritional state, with individual species disappearing and reappearing.

1 Nov 2022

Did COVID-19 mitigation measures in the United Kingdom impact the transmission of other infectious diseases?

Researchers explored the impact of the coronavirus disease 2019 (COVID-19) pandemic-associated non-pharmaceutical prevention measures on the transmission of 22 infectious diseases in England.

25 Oct 2022

Increased TMPRSS2 expression in tongue tissue of females and alcohol drinkers identified as a potential risk factor for SARS-CoV-2 infection

Researchers explored the association between the expressions of the ACE-2 receptor and TMPRSS2 in the tongue tissue and dysgeusia during SARS-CoV-2 infections.

17 Oct 2022

CCA's research initiative aims to identify progress, challenges in the lives of people with celiac disease

Twenty years after the first baseline survey of Canadians living with celiac disease was conducted, the Canadian Celiac Association (CCA) is mounting a major research initiative to identify progress made and continuing challenges surrounding life with the condition.

14 Oct 2022

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

One reason that it's so difficult to deliver large protein drugs orally is that these drugs can't pass through the mucus barrier that lines the digestive tract.

28 Sep 2022

Orally ingestible robotic drug delivery device overcomes barriers of the gastrointestinal environment

Oral drug delivery is the most common and cost-effective way to deliver a treatment. But drugs must make it through the harsh, acidic environment of the stomach, resist degradation by enzymes, penetrate the barrier posed by the mucus of the small intestine and overcome many other obstacles before they can be absorbed.

28 Sep 2022

Bile acids play an important role in regulating gut microbiome

Scientists performe in vitro and in vivo experiments to investigate the antimicrobial effects of different bile acids on various microorganisms.

27 Sep 2022

Researchers show how mucus protects the small intestine in mice

Researchers at the University of Gothenburg have now shown how mucus protects the small intestine in mice. In the future, this finding may lead to new ways of preventing relapse in Crohn’s disease in humans.

23 Sep 2022

Final results of the PATHFINDER study by GRAIL on multi-cancer early detection tests announced

A new press release announced the results of their interventional PATHFINDER study on the early detection of cancer using multi-cancer early detection (MCED) blood tests.

13 Sep 2022

The impact of the infant gut microbiome on vaccine efficacy

A new study reports the effect of the infant gut microbiome on vaccine efficacy.

13 Sep 2022

Pollutant particles in the air trigger lung cancer in non-smokers

A new mechanism has been identified through which very small pollutant particles in the air may trigger lung cancer in people who have never smoked, paving the way to new prevention approaches and development of therapies, according to late-breaking data [to be] reported at the ESMO Congress 2022 by scientists of the Francis Crick Institute and University College London, funded by Cancer Research UK. The particles, which are typically found in vehicle exhaust and smoke from fossil fuels, are associated with non-small cell lung cancer (NSCLC) risk, accounting for over 250,000 lung cancer deaths globally per year.

12 Sep 2022

Study may lead to a novel treatment strategy for inflammatory diseases by manipulating IκBζ function

In the normal small intestine, the levels of SFB and Th17 cells are both maintained constant as they counterbalance each other. Th17 cells release IL-17 to limit unwanted expansion of SFB, whereas decrease in the number of SFB eases the restrictive action of Th17 cells.

26 Aug 2022

Optimized human small intestinal organoids can help better study the functioning of small intestines

Researchers from the Organoid group (formerly the Clevers group) have improved human small intestinal organoids – miniature versions of the small intestine.

24 Aug 2022