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Designer DNA drug could be used to delay paralysis in ALS

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

17 Mar 2023

Criteria to assess for multiple sclerosis in adults may be insufficient for pediatric patients

Criteria used by neurologists to assess for multiple sclerosis (MS) in adults may fail to identify the illness in children with imaging suspicious for the disease, an oversight that could delay treatment of the disease at its earliest stages, according to a Rutgers study.

16 Mar 2023

Multivariate brain-wide associated studies can be replicable with substantially smaller sample sizes

Since the development of functional magnetic resonance imaging in the 1990s, the reliance on neuroimaging has skyrocketed as researchers investigate how fMRI data from the brain at rest, and anatomical brain structure itself, can be used to predict individual traits, such as depression, cognitive decline, and brain disorders.

16 Mar 2023

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

A new approach that delivers a "one-two punch" to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Mar 2023

Researchers design a virus-resistant, more useful E. coli bacteria

In a step forward for genetic engineering and synthetic biology, researchers have modified a strain of Escherichia coli bacteria to be immune to natural viral infections while also minimizing the potential for the bacteria or their modified genes to escape into the wild.

15 Mar 2023

New CDC opioid guidelines: Too little, too late for chronic pain patients?

Jessica Layman estimates she has called more than 150 doctors in the past few years in her search for someone to prescribe opioids for her chronic pain.

15 Mar 2023

New report focuses on promoting safer sleep for babies

Change is needed to the way safer sleep information is communicated, if risks to babies from unsafe sleeping practices are to be reduced, according to a new report from Oxford, UCL, Bristol and Newcastle Universities.

14 Mar 2023

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

A type of immune therapy called chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of multiple types of blood cancers but has shown limited efficacy against glioblastoma - the deadliest type of primary brain cancer - and other solid tumors.

14 Mar 2023

Innate immune molecule could be at the root of ALS

While drugs are on the market to slow the progression of neurodegenerative diseases, there are still no cures.

13 Mar 2023

New study focuses on genetic diversity of E. coli bacteria in hospitalized patients

The human intestine is an environment inhabited by many bacteria and other microorganisms collectively known as the gut microbiome, gut microbiota or intestinal flora. In most people, it contributes to wellness.

13 Mar 2023

Newly identified therapeutic target could lead to more effective treatment of glaucoma

Indiana University School of Medicine researchers have identified a new therapeutic target that could lead to more effective treatment of glaucoma.

10 Mar 2023

Seniors with anxiety frequently don’t get help. Here’s why.

Anxiety is the most common psychological disorder affecting adults in the U.S. In older people, it's associated with considerable distress as well as ill health, diminished quality of life, and elevated rates of disability.

10 Mar 2023

New class of oral drugs can inhibit a diverse range of pathogenic SARS-CoV-2 strains

The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections.

9 Mar 2023

Study suggests a new approach for treating metastatic breast cancers

Metastatic breast cancer has no cure and has proven stubbornly resistant to one of the most innovative and promising new cancer treatments: immunotherapy.

8 Mar 2023

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Mass General researchers have discovered a novel molecular mechanism responsible for the most common forms of acquired hydrocephalus, potentially opening the door to the first-ever nonsurgical treatment for a life-threatening disease that affects about a million Americans.

8 Mar 2023

Pilot trial tests nasal monoclonal antibody treatment for COVID-19

A pilot trial by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody.

8 Mar 2023

Study shows correlations between symptoms of long COVID and physical inactivity

The link between symptoms of COVID-19 and physical inactivity is increasingly evident.

8 Mar 2023

Racism contributes to disproportionate newborn drug testing

If a newborn tests positive for certain drugs after birth, mandated reporters in many states – including health care professionals and social workers – are required to report it to Child Protective Services.

8 Mar 2023

$Male geriatric patients at greater risk of skull fractures from falls than females$

Male geriatric patients at greater risk of skull fractures from falls than females

Each year, more than 3 million people ages 65 and older are treated in emergency departments for fall injuries. Head trauma is the leading cause of serious injury with skull fractures being reported as a serious outcome.

8 Mar 2023

Study illuminates how the brain senses infection

A new study led by researchers at Harvard Medical School illuminates how the brain becomes aware that there is an infection in the body.

8 Mar 2023

Medical School News and Research

Designer DNA drug could be used to delay paralysis in ALS

Criteria to assess for multiple sclerosis in adults may be insufficient for pediatric patients

Multivariate brain-wide associated studies can be replicable with substantially smaller sample sizes

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

Researchers design a virus-resistant, more useful E. coli bacteria

New CDC opioid guidelines: Too little, too late for chronic pain patients?

New report focuses on promoting safer sleep for babies

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

Innate immune molecule could be at the root of ALS

New study focuses on genetic diversity of E. coli bacteria in hospitalized patients

Newly identified therapeutic target could lead to more effective treatment of glaucoma

Seniors with anxiety frequently don’t get help. Here’s why.

New class of oral drugs can inhibit a diverse range of pathogenic SARS-CoV-2 strains

Study suggests a new approach for treating metastatic breast cancers

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Pilot trial tests nasal monoclonal antibody treatment for COVID-19

Study shows correlations between symptoms of long COVID and physical inactivity

Racism contributes to disproportionate newborn drug testing

Male geriatric patients at greater risk of skull fractures from falls than females

Study illuminates how the brain senses infection

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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