Protein C News and Research

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Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease

The tidal wave approaches. In the coming decades, Alzheimer's disease is projected to exact a devastating economic and emotional toll on society, with patient numbers in the US alone expected to reach 13.5 million by mid-century at a projected cost of over a trillion dollars.

30 Aug 2016

MedUni Vienna scientists aim to identify prognostic markers for cutaneous lymphomas

Primary cutaneous lymphomas, cancers of the lymphatic system, occur in the skin and originate either from T-lymphocytes (T-cell lymphomas, incidence 75%) or in B-cell lymphocytes (B-cell lymphomas, 25%).

30 Aug 2016

Selective manipulation of enzyme can stop cancer cachexia

Healthy fat tissue is essential for extended survival in the event of tumor-induced wasting syndrome (cachexia). In Nature Medicine, researchers at Helmholtz Zentrum München show that selective manipulation of an enzyme can stop unwanted metabolic processes.

30 Aug 2016

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

The Sarcoma research group of Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, has developed a modified version of an orthotopic model that allows researchers to recreate more closely the metastatic steps in Ewing sarcoma (ES), the second most common bone tumor in children and adolescents.

30 Aug 2016

Researchers find better way to purify liver cells made from induced pluripotent stem cells

A research team including developmental biologist Stephen A. Duncan, D. Phil., SmartState Chair of Regenerative Medicine at the Medical University of South Carolina, has found a better way to purify liver cells made from induced pluripotent stem cells (iPSCs).

30 Aug 2016

Gentle combination of FDA-approved drugs could combat photoreceptor degeneration in mice

In microseconds, every light ray that enters the eye triggers an explosion of coordinated cellular events.

29 Aug 2016

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Researchers at the National Center for Advancing Translational Sciences recently identified compounds that potentially can be used to inhibit Zika virus replication and reduce its ability to kill brain cells.

29 Aug 2016

Studying mutant peptides may help detect weaknesses in tumor cells

Researchers from MIPT, the Institute of Biomedical Chemistry, the Institute for Energy Problems of Chemical Physics, and the Research Institute of Physico-Chemical Medicine have presented an algorithm to detect mutant proteins based on mass spectrometry data and the results of exome sequencing.

29 Aug 2016

$Lipoprotein apheresis may have new role in patients with refractory angina$

Lipoprotein apheresis may have new role in patients with refractory angina

Initial investigation of patients with suspected coronary heart disease (CHD) using functional imaging - rather than guideline-directed care - resulted in significantly less unnecessary angiography, according to results of the CE-MARC 2 trial.

29 Aug 2016

Researcher identifies mechanisms that may cause resistance to BRAF inhibitor

BRAF mutation occurs in between 40% and 50% of metastasising melanomas (skin cancers), boosting tumour growth.

29 Aug 2016

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Janssen-Cilag International NV has announced the submission of a Type II variation application to the European Medicines Agency (EMA), seeking to broaden the existing marketing authorisation for the immunotherapy DARZALEX® (daratumumab) to include treatment of adult patients with relapsed multiple myeloma who have received at least one prior therapy. The expanded indication is based on daratumumab in combination with lenalidomide (an immmunomodulatory agent) and dexamethasone, or bortezomib (a PI) and dexamethasone.

29 Aug 2016

New test may help detect Parkinson's disease in early stages of illness

A test that can detect Parkinson's disease in the early stages of the illness has moved a step closer.

28 Aug 2016

Sanford-NDSU Collaborative Seed Grant Program provides funding for three health research projects

Three research projects have received $250,000 in seed funding from the Sanford Health NDSU Collaborative Seed Grant program. NDSU researchers will have opportunities to collaborate with investigators from Sanford Research.

28 Aug 2016

UT Southwestern researchers identify protein that can kick-start more efficient, healthful breakdown of fat

Researchers at UT Southwestern Medical Center have found that a protein often located on the surface of fat droplets within cells - and especially abundant in the muscles of endurance athletes - can kick-start the more efficient and healthful breakdown of fat.

27 Aug 2016

Penn State dermatologist clarifies common myths about psoriasis

Psoriasis is a much-misunderstood disease, often kept under wraps by sufferers who want to hide their skin lesions.

26 Aug 2016

Fiocruz to start phase II clinical trials of novel vaccine for schistosomiasis

The Oswaldo Cruz Foundation at Rio de Janeiro, Brazil, will start the phase II clinical trials of a vaccine for schistosomiasis, called 'Sm14 Vaccine'.

26 Aug 2016

Researchers find new way for early prediction of leukemic relapse

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

26 Aug 2016

Protein C News and Research

Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease

MedUni Vienna scientists aim to identify prognostic markers for cutaneous lymphomas

Selective manipulation of enzyme can stop cancer cachexia

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

Researchers find better way to purify liver cells made from induced pluripotent stem cells

Gentle combination of FDA-approved drugs could combat photoreceptor degeneration in mice

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Studying mutant peptides may help detect weaknesses in tumor cells

Lipoprotein apheresis may have new role in patients with refractory angina

Researcher identifies mechanisms that may cause resistance to BRAF inhibitor

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

New test may help detect Parkinson's disease in early stages of illness

Sanford-NDSU Collaborative Seed Grant Program provides funding for three health research projects

UT Southwestern researchers identify protein that can kick-start more efficient, healthful breakdown of fat

Penn State dermatologist clarifies common myths about psoriasis

Fiocruz to start phase II clinical trials of novel vaccine for schistosomiasis

Researchers find new way for early prediction of leukemic relapse

Researchers engineer protein-shelled nanostructures useful for ultrasound imaging

Hitchhiking of drugs on incorrect targets can cause adverse side effects

Chromatrap develops new range of optimised ChIP assay kits for genetic research

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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