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Researchers uncover one way breast cancer tumors resist vital medication

A team of Case Western Reserve University School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication.

11 Aug 2016

First investigational treatment for infantile-onset SMA shows promising results in clinical trial

A major milestone was reached when nusinersen, an investigational treatment for spinal muscular atrophy (SMA), was shown to significantly improve achievement of motor milestones in babies with infantile-onset SMA, according to an interim analysis of the double-blind, randomized, placebo controlled Phase 3 clinical trial called ENDEAR.

11 Aug 2016

New fluorescence microscopy approach improves image resolution by merging three views into one

Researchers have developed a new fluorescence microscopy approach that significantly improves image resolution by acquiring three views of a sample at the same time. Their new method is particularly useful for watching the dynamics of biological processes, which can provide insights into how healthy cells work and what goes wrong when diseases occur.

11 Aug 2016

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery.

11 Aug 2016

Study reveals people who fit better with culture have healthier eating habits

How to be a healthy eater depends on culture. A recent study shows that in the U.S. and Japan, people who fit better with their culture have healthier eating habits. The results appear in Personality and Social Psychology Bulletin.

11 Aug 2016

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Many cancers only become a mortal danger if they form metastases elsewhere in the body. Such secondary tumours are formed when individual cells break away from the main tumour and travel through the bloodstream to distant areas of the body.

11 Aug 2016

Integration of multiple types of protein biomarkers improves ability to detect breast cancer

A first-time study published in PLOS ONE shows that a combined assessment of multiple types of protein biomarkers in the blood offers an important advancement for detecting early breast cancer.

11 Aug 2016

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

RNA silencing technique developed by spinoff from UM-Madison effective in battling hepatitis B

A method for "silencing" RNA that emerged from a University of Wisconsin-Madison spinoff company is in clinical trials in Europe, Asia and the United States against hepatitis B, an infection that can destroy the liver.

11 Aug 2016

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Research from investigators at Rutgers Cancer Institute of New Jersey and Princeton University has identified a new approach to cancer therapy in cutting off a cancer cell's 'fuel supply' by targeting a cellular survival mechanism known as autophagy.

11 Aug 2016

Scientists create stable boron carrier for targeted radiation-based tumour therapies

Targeted radiation-based therapies for treating cancerous tumours such as 'boron neutron capture therapy' (BNCT), rely on the efficient and effective delivery of the capture agent (in this case, boron) to the tumour.

11 Aug 2016

Researchers examine different dietary approaches to help improve nutrition for poor in Zambia

Over the past several decades in Zambia, data from the Food and Agriculture Organization of the United Nations show that there has been a decrease in the per capita consumption of milk, meat, and eggs and an increase in starchy roots, primarily cassava.

11 Aug 2016

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis.

10 Aug 2016

Study finds oral immunotherapy safe, effective at suppressing peanut allergy in preschool children

Nearly 80 percent of peanut-allergic preschool children successfully incorporated peanut-containing foods into their diets after receiving peanut oral immunotherapy (OIT), a clinical trial has found.

10 Aug 2016

SBP researchers discover potential drug target for treatment of type 2 diabetes

Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new potential target for drugs to prevent type 2 diabetes. A paper published today in the Journal of Clinical Investigation shows that blocking a cellular glucose sensor in muscle improves insulin responsiveness.

10 Aug 2016

Rare genetic variations linked to severe porphyria

An international research team has linked rare variations in a cell membrane protein to the wide variation in symptom severity that is a hallmark of porphyria, a rare disorder that often affects the skin, liver and nervous system.

10 Aug 2016

Study shows overall prevalence of diabetic kidney disease remains unchanged among U.S. adults

Among U.S. adults with diabetes from 1988 to 2014, the overall prevalence of diabetic kidney disease did not change significantly, while the prevalence of albuminuria declined and the prevalence of reduced estimated glomerular filtration rate increased, according to a study appearing in the August 9 issue of JAMA.

10 Aug 2016

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers have uncovered how genes identified from genome-wide association studies (GWAS) affect high-density lipoprotein cholesterol (HDL-C), a biomarker of cardiovascular disease, after comparing several animal models with human patient data.

10 Aug 2016

Understanding brain circuit development: an interview with Dr Hollis Cline

There's a tremendous amount known about brain circuit development. Our work was inspired by experiments that were done over 50 years ago by scientists at Harvard University, Hubel and Wiesel. They received a Nobel Prize for their work and have inspired many additional experiments over the last 50 or 60 years.

10 Aug 2016

Research findings could provide framework for understanding fertilization mechanism

A Japanese research group has determined the crystal structure of the JUNO protein, an egg surface protein essential for fertilization. These structure-based mutational analyses elucidated a mechanism of the interaction between egg (JUNO protein) and sperm (IZUMO1) on a molecular level.

9 Aug 2016

Protein C News and Research

Researchers uncover one way breast cancer tumors resist vital medication

First investigational treatment for infantile-onset SMA shows promising results in clinical trial

New fluorescence microscopy approach improves image resolution by merging three views into one

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Study reveals people who fit better with culture have healthier eating habits

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Integration of multiple types of protein biomarkers improves ability to detect breast cancer

Novel computational analysis of prostate cancer suggests potential targets for therapy

RNA silencing technique developed by spinoff from UM-Madison effective in battling hepatitis B

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Scientists create stable boron carrier for targeted radiation-based tumour therapies

Researchers examine different dietary approaches to help improve nutrition for poor in Zambia

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Study finds oral immunotherapy safe, effective at suppressing peanut allergy in preschool children

SBP researchers discover potential drug target for treatment of type 2 diabetes

Rare genetic variations linked to severe porphyria

Study shows overall prevalence of diabetic kidney disease remains unchanged among U.S. adults

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Understanding brain circuit development: an interview with Dr Hollis Cline

Research findings could provide framework for understanding fertilization mechanism

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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