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Study discovers new therapy for aggressive blood cancer

Acute myeloid leukemia is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells.

13 Feb 2019

Study investigates the role of estrogen in controlling glucose homeostasis

The results of a recent Texas A&M University-led study provide insights into the mechanism by which estrogen can decrease insulin resistance and the production of glucose, reducing incidences of Type 2 diabetes mellitus.

13 Feb 2019

Lactate activates multiple genes that modulate neuronal activity

A genome-wide study led by Dean Pierre Magistretti sheds light on the mechanisms through which lactate regulates long-term memory formation and neuroprotection.

12 Feb 2019

Study shows precision medicines could aid more breast cancer patients via RNA-targeting

When women or men receive the worrisome diagnosis of breast cancer, that news comes with an important piece of information, namely, whether their cancer is HER2-positive or HER2-negative.

8 Feb 2019

Mutations in folliculin gene affect embryo implantation

New information is unfolding on the genetic controls of an early turning point in pregnancy. As the tiny, dividing cell mass, the blastocyst, travels from the oviduct and lodges in the wall of the uterus, the cells must exit their pre-implantation state and be ready for post-implantation development.

7 Feb 2019

HIV-1 protein plays broader role in suppressing immune response than thought

Scientists have revealed how a protein produced by HIV-1 plays a broader role in suppressing the immune system's response to infection than previously thought.

6 Feb 2019

Researchers identify regulatory mechanism underlying obesity

Obesity − as research in the past decade has shown − is first and foremost a brain disease. Researchers at Helmholtz Zentrum München, partners in the German Center for Diabetes Research, have now discovered a molecular switch that controls the function of satiety neurons and therefore body weight. The findings were published in the journal 'Nature Metabolism'.

31 Jan 2019

Exercise-induced muscle changes could help boost mood in older adults, study suggests

New research suggests that exercise-induced muscle changes could help boost mood in older adults. The study is published ahead of print in the American Journal of Physiology--Cell Physiology.

31 Jan 2019

RNA-binding protein needed for development of pathological hypertrophy

In response to conditions such as high blood pressure and reduced blood flow to cardiac muscle, the adult heart can drastically enlarge, a process called pathological hypertrophy that preserves cardiac function in the short term but predisposes patients to intractable heart failure and sudden cardiac death if left untreated.

31 Jan 2019

New autism mouse model shows how epigenetic regulation impacts downstream gene

The causes of autism spectrum disorder are diverse and to some extent, unknown. But without doubt, they are complex, layered and deeply nuanced.

31 Jan 2019

Researchers discover how transcription factors find specific loci within DNA

Bioengineering experts have discovered that transcription factors which bind non-specifically to mitotic chromosomes are more efficient at finding their binding site within DNA during interphase.

30 Jan 2019

Research provides new understanding of genome regulation in early life

After the fertilization of an egg cell, two become one; two sets of genetic information combine to form a genome. We can think of the egg and sperm as information capsules with stored instructions for starting a new life, but post fertilization, what kick starts the interpretation of these instructions?

29 Jan 2019

EZH2 mutations can be used as marker for diagnosing different types of cancers

Inside the cell, DNA is tightly wrapped around proteins and packed in a complex, 3D structure that we call "chromatin".

29 Jan 2019

Scientists pinpoint mechanism that leads to steroid diabetes

Patients undergoing long-term treatment with steroids may suffer from metabolic side effects. Researchers at the Helmholtz Zentrum München and the Ludwig Maximilians University of Munich, partners in the German Center for Diabetes Research, have now pinpointed a mechanism that leads to so-called steroid diabetes

25 Jan 2019

Novel therapeutic approach for treatment of leukemia

The BCR/ABL gene, which does not occur among healthy people, has been shown to be a causative agent in the pathogenesis of B-cell acute lymphocytic leukemia.

24 Jan 2019

Researchers uncover new role of heterochromatin in maintaining chromosomal integrity

Although many people are aware that chromosomal damage and shortening contribute to the aging process, understanding how chromosomal defects occur is about more than just finding a way to turn back the clock. Large changes in the structure of chromosomes, known as gross chromosomal rearrangements, can result in cell death or genetic diseases such as cancer.

24 Jan 2019

Enzyme that breaks down amino acids plays key role in promoting cellular senescence

Permanently arrested cell growth is known as "cellular senescence", and the accumulation of senescent cells may be one cause of aging in our bodies. Japanese researchers have discovered that a certain enzyme in our bodies promotes cellular senescence by producing reactive oxygen species.

24 Jan 2019

Researchers gain new insights into development of necrotizing enterocolitis in preemies

Researchers at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues, discovered a promising direction toward understanding the development of necrotizing enterocolitis, a devastating intestinal disease commonly affecting premature infants, in order to treat it.

23 Jan 2019

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Using a new epigenetics-based approach, scientists have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease.

22 Jan 2019

Researchers identify new peptide that helps lateral roots to grow with right spacing

How do plants space out their roots? A Japanese research team has identified a peptide and its receptor that help lateral roots to grow with the right spacing.

21 Jan 2019