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Solar irradiation inactivates SARS-CoV-2 and other human coronaviruses, finds study

Coronaviruses irradiated with simulated sunlight used to infect cells showed reduced infectivity and reduced viral replication compared to viruses that were not irradiated.

30 Jun 2021

SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

In an effort to hasten the research on identifying antiviral drugs for SARS-CoV-2 infection, researchers from the U.S. and Switzerland performed extensive drug screening for antiviral activity using live virus infection in human respiratory cells. As a result, they identified a set of possible drug candidates that could potentially be tested in clinical trials.

30 Jun 2021

The technology behind face masks that can diagnose COVID-19

Researchers have recently incorporated technology into standard face masks to detect the presence of SARS-CoV-2.

29 Jun 2021

Nanotechnology and the fight against COVID-19

In a review paper published in the open-access MDPI journal Viruses, a team of researchers explored the potential of nanotechnology to alleviate the current and future coronavirus burden. The team focused on its potential role in the detection, diagnosis, protection, and treatment of SARS-CoV-2 infection.

29 Jun 2021

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

Researchers from Canada recently presented an efficient strategy for recombinant production of enzymatically active TMPRSS2 ectodomain, enabling enzymatic characterization and the 1.95 Å X-ray crystal structure. Their work is published on the bioRxiv* preprint server while awaiting peer-review.

29 Jun 2021

SARS-CoV-2 test in 20 minutes with FISH

A collaboration from the University of Oxford and the University of Warwick has led to research into a novel method of viral detection through rapid fluorescence in situ hybridization (FISH) in order to effectively detect the SARS-CoV-2 virus within 20 minutes.

29 Jun 2021

Scientists develop a simple, noninvasive diagnostic solution for Alzheimer's disease

An international research team led by HKUST has developed a simple but robust blood test from Chinese patient data for early detection and screening of Alzheimer's disease (AD) for the first time, with an accuracy level of over 96%.

28 Jun 2021

Could the activation of FcγRIII/CD16 by anti-spike SARS-CoV-2 antibodies independently determine COVID-19 severity?

A team of scientists from Germany recently investigated whether hyperactivation of immune receptors that recognize the Fc part of an IgG molecule (FcγR) can lead to immunopathologic changes in coronavirus disease 2019 (COVID-19) patients. They have observed that hyperactivation of FcγRIII (CD16) by proinflammatory IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can significantly contribute to COVID-19 related immunopathology.

28 Jun 2021

Study finds minimal SARS-CoV-2 viral load in vaginal secretions

The virus has also been observed to be present in blood, urine, feces, and tears, though not in semen. Vaginal secretions have not been consistently shown to be positive for the virus in most studies. The authors of a new study in the Journal of Clinical Medicine affirm that the presence of the virus in the vagina is rare, irrespective of pregnancy.

28 Jun 2021

Why SARS-CoV-2 delta variant is more infectious

German experts recently explained why the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant is more infectious and pathogenic than its ancestor. By conducting a series of in vitro experiments, they have revealed that increased ability to induce cell-to-cell fusion (syncytia) and reduced susceptibility to vaccine and infection-induced antibodies make the delta variant more infectious than previously circulating variants. The study is currently available on the bioRxiv* preprint server.

28 Jun 2021

Novel biosensor offers rapid quantitative variant of concern-independent serology for SARS-CoV-2

Even as herculean efforts are being made to extend the reach of vaccination against COVID-19 to all the regions of the world, there is a dire need for rapid and sensitive tests to assess the antibody response to the various vaccines used and to monitor antibody titers over time. A new preprint describes a new approach to this problem which could be applied to other molecules of interest as well, both in laboratories and at the point of care.

25 Jun 2021

Researchers develop a low-cost automated rapid test for detecting SARS-CoV-2 antibodies

During the continued progression of the Corona pandemic, rapid, inexpensive, and reliable tests will become increasingly important to determine whether people have the associated antibodies - either through infection or vaccination.

24 Jun 2021

New tablet-sized device can profile multiple COVID-19 antibodies and biomarkers simultaneously

Biomedical engineers at Duke University in the USA have developed a device that detects coronavirus disease (COVID-19) antibodies as well as biomarkers that distinguish between antibodies produced in response to SARS-CoV-2 and four other coronaviruses with complete accuracy.

24 Jun 2021

COVID-19 prevalence in the U.S. has far exceeded the known number of cases

In a new study, National Institutes of Health researchers report that the prevalence of COVID-19 in the United States during spring and summer of 2020 far exceeded the known number of cases and that infection affected the country unevenly.

24 Jun 2021

A study of circulating biomarkers in hospitalized patients infected with SARS-CoV-2 alpha variant

Now, a new study published on the medRxiv* preprint server proposes a rapid method to identify the mutations in B.1.1.7 (N501Y mutation and H69/V70 deletion) and the impact of this variant on various biomarkers in hospitalized patients. This is the first study that correlates the biomarker levels to SARS-CoV-2 variants.

23 Jun 2021

SARS-CoV-2 detection with a simple, inexpensive, and sensitive molecular test

Researchers from the US recently described a rapid molecular test named WHotLAMP for the detection of SARS-CoV-2 in saliva. WHotLAMP is easy to use, very sensitive at 3.6 viral RNA copies per microliter of saliva, specific, and inexpensive. This study is published on the medRxiv*preprint serve.

23 Jun 2021

Research suggests people living with HIV/AIDS may be less susceptible to SARS-CoV-2

Researchers in India have conducted a study showing that the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – was lower among people living with HIV and AIDS than among the general population.

23 Jun 2021

Blood test shows promise for predicting treatment response in patients with advanced HPV-positive throat cancer

A sensitive blood test being developed by a team of researchers at the University of Michigan Rogel Cancer Center shows promise for predicting whether patients with metastatic HPV-positive throat cancer will respond to treatment months earlier than standard imaging scans.

23 Jun 2021

Natural compound myricetin shows antiviral potential against SARS-CoV-2

New findings from a team of Chinese researchers suggest natural compounds — specifically the flavonoid myricetin — could also be a potential drug candidate for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

23 Jun 2021

Study: Odorant receptor recognizes pyrazines in both humans and domesticated animals

A team of scientists from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now discovered that the odorant receptor OR5K1 is specialized to recognize pyrazines in both humans and domesticated animals.

23 Jun 2021

Assay News and Research

Solar irradiation inactivates SARS-CoV-2 and other human coronaviruses, finds study

SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

The technology behind face masks that can diagnose COVID-19

Nanotechnology and the fight against COVID-19

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

SARS-CoV-2 test in 20 minutes with FISH

Scientists develop a simple, noninvasive diagnostic solution for Alzheimer's disease

Could the activation of FcγRIII/CD16 by anti-spike SARS-CoV-2 antibodies independently determine COVID-19 severity?

Study finds minimal SARS-CoV-2 viral load in vaginal secretions

Why SARS-CoV-2 delta variant is more infectious

Novel biosensor offers rapid quantitative variant of concern-independent serology for SARS-CoV-2

Researchers develop a low-cost automated rapid test for detecting SARS-CoV-2 antibodies

New tablet-sized device can profile multiple COVID-19 antibodies and biomarkers simultaneously

COVID-19 prevalence in the U.S. has far exceeded the known number of cases

A study of circulating biomarkers in hospitalized patients infected with SARS-CoV-2 alpha variant

SARS-CoV-2 detection with a simple, inexpensive, and sensitive molecular test

Research suggests people living with HIV/AIDS may be less susceptible to SARS-CoV-2

Blood test shows promise for predicting treatment response in patients with advanced HPV-positive throat cancer

Natural compound myricetin shows antiviral potential against SARS-CoV-2

Study: Odorant receptor recognizes pyrazines in both humans and domesticated animals

eBook: Using iPSCs models for human disease research and drug discovery eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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