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What older Americans need to know about taking Paxlovid

A new coronavirus variant is circulating, the most transmissible one yet. Hospitalizations of infected patients are rising. And older adults represent nearly 90% of U.S. deaths from covid-19 in recent months, the largest portion since the start of the pandemic.

18 Jan 2023

Modification to Hospital Elder Life Program expands delirium prevention

A new study published in the Journal of American Geriatrics Society (JAGS) found that modifying a well-established and highly successful delirium prevention program for use when in-person or face-to-face interactions are limited or restricted is both feasible and acceptable to hospital staff and patients.

17 Jan 2023

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

For people with paralysis caused by neurologic injury or disease - such as ALS (also known as Lou Gehrig's disease), stroke, or spinal cord injury - brain-computer interfaces (BCIs) have the potential to restore communication, mobility, and independence by transmitting information directly from the brain to a computer or other assistive technology.

16 Jan 2023

Study shows the importance of social support in buffering genetic depression risk

Reaching out to support a person when they're under stress is always a good idea. But a new study suggests that support could be especially important for someone whose genetic makeup makes them more likely to develop depression.

13 Jan 2023

“Zone of uncertainty” communicates with the neocortex to rapidly control memory formation

The neocortex is the largest and most complex part of the brain and has long been considered the ultimate storage site for long-term memories. But how are traces of past events and experiences laid down there?

13 Jan 2023

Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

One of the most important classes of human enzymes are protein kinases - signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

12 Jan 2023

Silencing the immune evasion gene enhances cancer cells' susceptibility to immunotherapy

Immune checkpoint inhibitors are important medications that boost the immune system's response against various cancers, but some patients' cancer cells are unaffected by the drugs or develop resistance during treatment.

12 Jan 2023

Machine learning-based behavioral intervention can improve end-of-life cancer care

Electronic nudges delivered to health care clinicians based on a machine learning algorithm that predicts mortality risk quadrupled rates of conversations with patients about their end-of-life care preferences, according to the long-term results of a randomized clinical trial published by Penn Medicine investigators in JAMA Oncology today.

12 Jan 2023

ADDF-Harrington partnership accelerates the translation of innovative Alzheimer's research into therapies

The Alzheimer's Drug Discovery Foundation and Harrington Discovery Institute at University Hospitals in Cleveland have granted an ADDF-Harrington Scholar Award to Christiane Wrann, PhD, DVM, Associate Professor in Medicine at the Cardiovascular Research Center and the McCance Center for Brain Health at Massachusetts General Hospital and the Harvard Medical School in Boston.

12 Jan 2023

Experts propose solutions to address racial disparities affecting people with allergic conditions

In February 2022, the American College of Allergy, Asthma and Immunology convened experts in atopic dermatitis (AD) and food allergy to examine the issue of racial disparities affecting people with these conditions.

12 Jan 2023

New UC San Diego Shiley EyeMobile for Children visits schools to serve low-income families

The new UC San Diego Shiley EyeMobile for Children has started its engine and is driving to schools in San Diego County to serve low-income families in need of eye exams.

12 Jan 2023

Newly revised classification tool for standardized diagnostic reporting of melanocytic lesions

With the growing number of skin biopsies performed annually for suspected melanoma, a simple, easily understood standardized classification system for melanocytic lesions is increasingly important to aid pathologists and clinicians who examine millions of tissue samples each year and to alleviate patient confusion and anxiety.

11 Jan 2023

CAR T cell therapy may enhance the effectiveness of surgery for solid tumors

CAR T cell therapy, an approach which reprograms patients' own immune cells to attack their blood cancers, may enhance the effectiveness of surgery for solid tumors, according to a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

11 Jan 2023

Medicare policy change may lead to increased inequities in access to heart transplants

A change to Medicare policy surrounding heart transplant may lead to increased inequities in access to transplant for patients with heart failure, a Michigan Medicine study finds.

11 Jan 2023

Tooth loss more frequent among Black women in Brazil

In Brazil, tooth loss is 19% more frequent among Black women than White men. Among women, it is 26% more frequent for Blacks than Whites. Among Blacks, self-defined on the basis of skin color, it is 14% more frequent for women than men. Black women are affected most, whatever the parameter.

11 Jan 2023

Simple method increases the efficacy of T cell therapy by cytokine conjugation

The recent years have seen a wave of adoptive cell therapies (ACTs), a type of immunotherapy in which T cells (T cell transfer therapy) and other immune cells are obtained from patients, activated and multiplied outside the body, and infused in larger numbers back into the blood circulation to help fight cancers.

11 Jan 2023

The decision of where to seek care is complicated by the multitude of options

One evening in February 2017, Sarah Dudley's husband, Joseph, started to feel sick. He had a high fever, his head and body ached, and he seemed disoriented, she said. The Dudleys had a decision to make: go to the hospital emergency room or to an urgent care clinic near their home in Des Moines, Iowa.

11 Jan 2023

Medical School News and Research

What older Americans need to know about taking Paxlovid

Modification to Hospital Elder Life Program expands delirium prevention

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

Study shows the importance of social support in buffering genetic depression risk

“Zone of uncertainty” communicates with the neocortex to rapidly control memory formation

Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

Silencing the immune evasion gene enhances cancer cells' susceptibility to immunotherapy

Machine learning-based behavioral intervention can improve end-of-life cancer care

ADDF-Harrington partnership accelerates the translation of innovative Alzheimer's research into therapies

Experts propose solutions to address racial disparities affecting people with allergic conditions

New UC San Diego Shiley EyeMobile for Children visits schools to serve low-income families

Newly revised classification tool for standardized diagnostic reporting of melanocytic lesions

CAR T cell therapy may enhance the effectiveness of surgery for solid tumors

Medicare policy change may lead to increased inequities in access to heart transplants

Tooth loss more frequent among Black women in Brazil

Simple method increases the efficacy of T cell therapy by cytokine conjugation

The decision of where to seek care is complicated by the multitude of options

Study describes a mechanism associated with the production of neuropathic pain

Researchers demonstrate the role of Klotho protein in the formation of osteoarthritis

Study opens a new view about the science of consciousness

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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