Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Combination of anti-angiogenic and immune-stimulating therapies can lead to effective cancer treatments

Scientists from VIB and KU Leuven, together with colleagues from the University of California and the Swiss Institute for Experimental Cancer Research have demonstrated that, anti-angiogenic therapy can improve immune boosting treatments.

13 Apr 2017

Vascular risk factors increase risk of Alzheimer's disease in late-life, study reveals

A study published in The Journal of the American Medical Association (JAMA) reveals that an increasing number of vascular risk factors such as obesity, high blood pressure, diabetes, high cholesterol, and smoking during midlife contributes to increased brain amyloid levels (protein fragments associated with Alzhemier’s, the most common form of dementia) in later life.

13 Apr 2017

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Using the new gene-editing enzyme CRISPR-Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

13 Apr 2017

Clemson University researcher receives NIH grant to advance study into abdominal aortic aneurysms

One of the top ten killers for men older than 55 is the target of Clemson University research that could lead to a new life-saving therapy and a better way of telling whether surgery is necessary.

12 Apr 2017

Targeted treatment slows progression of two degenerative brain diseases in mice

Scientists report a significant step toward combatting two degenerative brain diseases that chip away at an individual's ability to move, and think.

12 Apr 2017

Gladstone scientists discover common mechanism that links neurodegeneration in young and old

Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF), identified a common mechanism in two forms of neurodegeneration that affect young adults or the elderly.

12 Apr 2017

NIH scientists identify protein complexes involved in promoting HSV infection and reactivation

Herpes simplex virus (HSV) infections last a lifetime. Once a person has been infected, the virus can remain dormant (latent) for years before periodically reactivating to cause recurrent disease. This poorly understood cycle has frustrated scientists for years.

12 Apr 2017

'Human knockouts': Genetics in families reveals basic biology and possible therapeutics for disorders

More than 1,800 individuals carrying loss-of-function mutations in both copies of their genes, so-called "human knockouts," are described in the first major study to be published in Nature this week by an international collaboration led by the Perelman School of Medicine at the University of Pennsylvania and colleagues.

12 Apr 2017

Scientists discover how insulin-producing cells show differences in age

Diabetes researchers have puzzled for decades about why insulin-producing beta cells in one pancreatic islet often look and behave quite differently than their counterparts in the same islet or in nearby islets.

12 Apr 2017

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

A microscopic corn-and-shrimp cocktail could eventually make DNA-based vaccinations and cancer-treating gene therapies an easier pill to swallow, according to new research from the University of Nebraska-Lincoln.

12 Apr 2017

Prevention, not cure, may be key to stopping Alzheimer’s disease

It has been 111 years since Auguste D. became the first person described with what is now called Alzheimer's disease.

12 Apr 2017

Transmembrane protein complexes shed light on antibiotic resistance in bacteria

An international team including researchers from MIPT’s Laboratory for Advanced Studies of Membrane Proteins have proposed an explanation of the way bacteria process external signals.

12 Apr 2017

Study may provide insight into how R-LA promotes death of hepatoma cells

A new study that measured metabolite levels over time in starved rat liver cancer cells showed that treatment with a form of alpha-lipoic acid (LA) inhibited glucose uptake and glycolysis, and led to decreased cellular glucose production from non-carbohydrate sources, which may help explain how the naturally occurring R enantiomeric form of LA (R-LA) promotes the death of hepatoma cells.

12 Apr 2017

PID1 gene increases killing effect of chemotherapy drugs on brain tumor cells

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have found that the gene PID1 enhances killing of medulloblastoma and glioblastoma cells.

11 Apr 2017

Researchers use genetic manipulation to regenerate auditory hair cells in adult mice

In an apparent first, St. Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice. The research marks a possible advance in treatment of hearing loss in humans. The study appears today in the journal Cell Reports.

11 Apr 2017

Researchers uncover mechanism that leads to disorders in pancreatic development, infant diabetes

Researchers at the University of Helsinki, Finland, have uncovered a mechanism through which a mutation in the STAT3 gene leads to a disorder in the development of the pancreas and to infant diabetes.

11 Apr 2017

Scientists discover promising target to treat highly aggressive brain tumor in infants

Using state-of-the-art gene editing technology, scientists from Ann & Robert H. Lurie Children's Hospital of Chicago have discovered a promising target to treat atypical teratoid/rhabdoid tumor (AT/RT) – a highly aggressive and therapy resistant brain tumor that mostly occurs in infants.

11 Apr 2017

Antimicrobial protein reduces creamy white lesions linked to oral thrush in mouse models

An antimicrobial protein caused a dramatic reduction in the creamy white lesions associated with oral thrush in a preclinical study, report microbiologists with McGovern Medical School at The University of Texas Health Science Center at Houston.

11 Apr 2017

Activation of specific protein could lead to acute lymphoblastic leukemia, study reveals

The discovery of a protein signature that is highly predictive of leukemia could lead to novel treatments of the leading childhood cancer, according to new study showing that competition among certain proteins causes an imbalance that leads to leukemia.

11 Apr 2017

Researchers design first light-activated drug for treatment of pain

A team of the Institute of Neurosciences of the University of Barcelona has participated in the design of the first light-activated drug -the JF-NP-26, for the treatment of pain, according to a research with animal models published in the journal eLife.

11 Apr 2017

Protein News and Research

Further Reading

Combination of anti-angiogenic and immune-stimulating therapies can lead to effective cancer treatments

Vascular risk factors increase risk of Alzheimer's disease in late-life, study reveals

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Clemson University researcher receives NIH grant to advance study into abdominal aortic aneurysms

Targeted treatment slows progression of two degenerative brain diseases in mice

Gladstone scientists discover common mechanism that links neurodegeneration in young and old

NIH scientists identify protein complexes involved in promoting HSV infection and reactivation

'Human knockouts': Genetics in families reveals basic biology and possible therapeutics for disorders

Scientists discover how insulin-producing cells show differences in age

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

Prevention, not cure, may be key to stopping Alzheimer’s disease

Transmembrane protein complexes shed light on antibiotic resistance in bacteria

Study may provide insight into how R-LA promotes death of hepatoma cells

PID1 gene increases killing effect of chemotherapy drugs on brain tumor cells

Researchers use genetic manipulation to regenerate auditory hair cells in adult mice

Researchers uncover mechanism that leads to disorders in pancreatic development, infant diabetes

Scientists discover promising target to treat highly aggressive brain tumor in infants

Antimicrobial protein reduces creamy white lesions linked to oral thrush in mouse models

Activation of specific protein could lead to acute lymphoblastic leukemia, study reveals

Researchers design first light-activated drug for treatment of pain

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