Protein C News and Research

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Cardiac reprogramming could shrink heart scar tissue, improve patients' heart function

Patients with heart failure often have a buildup of scar tissue that leads to a gradual loss of heart function. In a new study published today in the journal Cell Stem Cell, researchers from the University of North Carolina School of Medicine report significant progress toward a novel approach that could shrink the amount of heart scar tissue while replenishing the supply of healthy heart muscle.

4 Mar 2016

Healthy cells actively collaborate with tumours to promote growth of new blood vessels

Healthy cells actively collaborate with tumours by creating a mesh of collagen that encourages cancer cells to build new blood vessels, a new study shows.

4 Mar 2016

Researchers uncover new pathway for mitochondrial cell death

Researchers at St. Jude Children's Research Hospital have uncovered a new pathway for mitochondrial cell death that involves the protein BCL-2 ovarian killer, otherwise known as BOK. The discovery, which is described online in the journal Cell, may lead to new ways to trigger cell death in some types of cancer cells.

4 Mar 2016

Study provides critical insight into Warburg effect

PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.

4 Mar 2016

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Researchers at Schepens Eye Research Institute of Massachusetts Eye and Ear have shown a link between mitochondrial dysfunction in corneal endothelial cells and the development of Fuchs' Endothelial Corneal Dystrophy.

4 Mar 2016

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

A protein modified to increase the amount of time it circulates in the bloodstream appears to reverse liver fibrosis and cirrhosis in rats, according to results of a study led by Johns Hopkins researchers.

3 Mar 2016

Unlocking H5N1 virus replication: an interview with Martin Blackledge

We were able to show that one small domain of the polymerase, the part that is essential for entry of a piece of the polymerase into the cell nucleus, changes its conformation to allow it to interact with the transporter protein than takes it into the nucleus.

3 Mar 2016

Differences in certain type of small protein may shed light on lung cancer risk in different races

Research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from the National Cancer Institute and other facilities, shows differences in a certain type of small protein vary by race and may contribute differently to the development of lung cancer in African Americans and European Americans.

3 Mar 2016

New MyGene2 web tool may help find genes influencing Mendelian disorders

A new web tool, MyGene2, will enable patients and their families to join clinicians and scientists in the search for genes underlying rare disorders. The sharing of health information also will improve knowledge about how gene variants influence symptoms and other clinical features of Mendelian disorders.

3 Mar 2016

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

When the heart begins to fail, the body does everything in its power to fix the situation. But sometimes, those compensatory mechanisms ultimately do more harm than good. Such is the case with the adrenal hormone aldosterone, which stimulates the heart to pump harder, causing greater damage to the heart muscle.

3 Mar 2016

Scientists solve first 3-D structure of DNAzyme

DNA does not always adopt the form of the double helix which is associated with the genetic code; it can also form intricate folds and act as an enzyme: a deoxyribozyme. A researcher from Spain and other scientists from the Max Planck Institute for Biophysical Chemistry (Germany) have solved the first three-dimensional structure of this biomolecule that has proved much more flexible than previously thought.

3 Mar 2016

Common blood test could help predict risk of second stroke

A new discovery about ischemic stroke may allow to doctors to predict a patient's risk of having a second stroke using a commonly performed blood test and their genetic profile.

3 Mar 2016

Rice university researchers uncover elusive lung cancer cells

Researchers at Rice University and the University of Texas MD Anderson Cancer Center have uncovered a trick used by lung cancer cells to hide from the body's immune system.

3 Mar 2016

U-M researchers develop novel mouse model of children's brain cancer

Children with brain cancer may soon get some help from mice with the same disease, thanks to new research from University of Michigan Medical School scientists and their colleagues.

3 Mar 2016

New study shows that individuals with higher protein intake feel more full after meals

Many people turn to high-protein foods when trying to lose weight because eating protein-rich meals is commonly believed to make dieters feel fuller. Surprisingly, this idea hadn't been tested on a large scale.

3 Mar 2016

Inhibitors that activate brown fat may help treat diabetes, metabolic disorders

In recent decades, obesity has become a global problem. The disease goes hand in hand with a dramatic increase in the proportion of body fat. Researchers from the Max Planck Institute for Metabolism Research and the Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases at the University of Cologne have now succeeded in inhibiting a protein in mice that hampers activation of the useful "brown fat" in obese mice. When treated with inhibitors against this protein, obese mice exhibited a notable improvement of their glucose metabolism.

2 Mar 2016

Blueberry Therapeutics set to create safe, effective nanomedicines to tackle unmet healthcare needs

Blueberry Therapeutics Ltd, a leading pharmaceutical company focused on the major medical problems of inflammation and infection, are exploring the anti-microbial agenda through the development of new anti-fungal drugs and treatments to tackle this important unmet healthcare need.

2 Mar 2016

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Researchers show that the protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis.

2 Mar 2016

Beta blockers may improve effectiveness of triple negative breast cancer treatments

New research published in the March 2016 issue of The FASEB Journal, shows that a commonly prescribed class of high blood pressure drugs may have the potential to slow the growth of triple negative breast cancer tumors. These drugs, called "beta blockers" work by counteracting the pro-growth effect caused by adrenaline by affecting the the beta2-adrenoceptor.

2 Mar 2016

Polyunsaturated lipids can alter binding rate of two receptors involved in Parkinson's and Alzheimer's

A study published in the prestigious journal Scientific Reports from the Nature group demonstrates, for the first time and using computational tools, that polyunsaturated lipids can alter the binding rate of two types of receivers involved in certain nervous system diseases.

2 Mar 2016

Protein C News and Research

Cardiac reprogramming could shrink heart scar tissue, improve patients' heart function

Healthy cells actively collaborate with tumours to promote growth of new blood vessels

Researchers uncover new pathway for mitochondrial cell death

Study provides critical insight into Warburg effect

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

Unlocking H5N1 virus replication: an interview with Martin Blackledge

Differences in certain type of small protein may shed light on lung cancer risk in different races

New MyGene2 web tool may help find genes influencing Mendelian disorders

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

Scientists solve first 3-D structure of DNAzyme

Common blood test could help predict risk of second stroke

Rice university researchers uncover elusive lung cancer cells

U-M researchers develop novel mouse model of children's brain cancer

New study shows that individuals with higher protein intake feel more full after meals

Inhibitors that activate brown fat may help treat diabetes, metabolic disorders

Blueberry Therapeutics set to create safe, effective nanomedicines to tackle unmet healthcare needs

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Beta blockers may improve effectiveness of triple negative breast cancer treatments

Polyunsaturated lipids can alter binding rate of two receptors involved in Parkinson's and Alzheimer's

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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