Angiotensin Converting Enzyme 2 News and Research

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Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

A study tested the hypothesis that the ACE-2 receptor of SARS-CoV-2 is not only an attachment factor in viral infection but also plays a role in activating the viral spike protein to facilitate membrane fusion.

27 Oct 2022

What is the efficacy of RT-PCR assays for detection of SARS-CoV-2 in human semen?

A new study aimed to develop a standardized protocol for SARS-CoV-2 RNA detection in semen fractions used for assisted reproductive technology.

26 Oct 2022

COVID-19 and the gut

Researchers summarize current knowledge about underlying mechanisms and potential therapeutic approaches for the effects of COVID-19 on the gut.

26 Oct 2022

DNA damage in older age increases expression of ACE2 and SARS-CoV-2 infection risk

Impaired DNA repair capacity among elderly increases expression of ACE2 receptor.

26 Oct 2022

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

In a new study, researchers performed an in vitro analysis to isolate ultralong bovine heavy chains that showed binding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses (CoVs).

24 Oct 2022

What is the efficacy of mulberry component Kuwanon C against COVID-19?

A recent study determined the underlying antiviral mechanism of KC associated with the inhibition of SARS-CoV-2.

24 Oct 2022

Study shows hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron sublineages

Researchers evaluated imprinted antibody responses against SARS-CoV-2 Omicron sublineages.

24 Oct 2022

Relationship between COVID-19 and chilblains

A recent study discusses the associations between chilblains and COVID-19.

23 Oct 2022

How does COVID-19 and its treatment affect testicular function?

Researchers summarized available information related to the reproductive effects of COVID-19 in men.

23 Oct 2022

Biochemical and structural evidence demonstrates Omicron mutations are better adapted to mouse ACE2 than to human ACE2

Researchers demonstrated the structural basis of how the receptor-binding domain nested Omicron mutations have adapted to mouse angiotensin-converting enzyme 2 rather than human ACE2.

22 Oct 2022

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

Researchers at Boston University made a chimeric recombinant SARS-CoV-2 encoding the spike glycoprotein gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate.

22 Oct 2022

Exploring SARS-CoV-2-associated endothelial dysfunction

A new study described the evidence, mechanisms, and therapies for endothelial dysfunction in coronavirus disease 2019 (COVID-19).

21 Oct 2022

Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity

In a recent study published in the journal Nature Cell Biology, researchers demonstrated the susceptibility of salivary glands to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in vitro using an organoid culture model.

20 Oct 2022

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

In a recent study posted to the bioRxiv* preprint server, researchers at Ohio State University and the University of Texas Medical Branch assessed the underlying mechanisms involved in the fusogenicity and endosomal entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants.

20 Oct 2022

Licorice root extract shows potential as a COVID-19 treatment

A recent study explores the activity of glycyrrhizin against SARS-CoV-2.

19 Oct 2022

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Researchers discussed the pathophysiological mechanisms of endothelial dysfunction associated with severe coronavirus disease 2019 (COVID-19) and commented on the potential therapeutic strategies to treat endothelial damage and coagulopathy related to COVID-19.

19 Oct 2022

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19).

19 Oct 2022

Adaptation-proof SARS-CoV-2 vaccine design is one step closer to reality

A vaccine design approach that could protect against new variants of SARS-CoV-2, the virus that causes COVID-19, but also potentially protects against other coronaviruses is one step closer to reality as a result of Penn State College of Medicine research.

18 Oct 2022

Does skin inflammation exacerbate COVID-19?

In a new study, researchers discussed inflammation during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18 Oct 2022

Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae?

A new study evaluated the current research on incidences of hypertension, new-onset diabetes mellitus, and dyslipidemia as possible sequelae of coronavirus disease 2019 (COVID-19).

18 Oct 2022

Angiotensin Converting Enzyme 2 News and Research

Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

What is the efficacy of RT-PCR assays for detection of SARS-CoV-2 in human semen?

COVID-19 and the gut

DNA damage in older age increases expression of ACE2 and SARS-CoV-2 infection risk

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

What is the efficacy of mulberry component Kuwanon C against COVID-19?

Study shows hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron sublineages

Relationship between COVID-19 and chilblains

How does COVID-19 and its treatment affect testicular function?

Biochemical and structural evidence demonstrates Omicron mutations are better adapted to mouse ACE2 than to human ACE2

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

Exploring SARS-CoV-2-associated endothelial dysfunction

Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

Licorice root extract shows potential as a COVID-19 treatment

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Adaptation-proof SARS-CoV-2 vaccine design is one step closer to reality

Does skin inflammation exacerbate COVID-19?

Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae?

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