CLARITY News and Research

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The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.

Scientists uncover hidden genetic causes of congenital heart disease

Scientists at the Icahn School of Medicine at Mount Sinai and collaborators have identified novel genetic interactions that may contribute to congenital heart disease (CHD), a common birth defect.

20 Feb 2025

Novel classification system for SJS/TEN aims to improve patient care

First identified by Stevens and Johnson in 1922, SJS and TEN are now recognized as disorders with a continuum of severity, from milder forms (SJS) to the most severe (TEN).

19 Feb 2025

Fear of cancer recurrence disrupts many aspects of breast cancer survivors' lives

Breast cancer is the world's most prevalent cancer. Although earlier detection and targeted treatment have resulted in high survival rates, many breast cancer survivors experience fear of cancer recurrence. For some survivors this fear is occasional, for others it is persistent and often debilitating.

7 Feb 2025

Trump’s order on gender-affirming care escalates reversal of trans rights

President Donald Trump ratcheted up his administration's reversal of transgender rights on Tuesday with an executive order that seeks to intervene in parents' medical decisions by prohibiting government-funded insurance coverage of puberty blockers or surgery for people under 19.

31 Jan 2025

Longer caregiving hours tied to worse menopause symptoms in women

Researchers have identified a link between the number of caregiving hours per week a woman performs and menopause symptom burden.

30 Jan 2025

Trump’s funding ‘pause’ throws states, health industry into chaos

States and the nation's health industry were thrown into disarray after the Trump administration ordered Monday that the government freeze nearly all federal grants at 5 p.m. ET Tuesday, a sweeping directive that at least initially appeared to include funding for Medicaid, the state-federal health insurance program that covers more than 70 million Americans.

28 Jan 2025

AI tools show potential to improve aging interventions and recommendations

A collaborative study between researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and the Institute for Biostatistics and Informatics in Medicine and aging Research, Rostock University Medical Center, Germany, investigated how advanced AI tools, like Large Language Models (LLMs), can make it easier to evaluate interventions for aging and provide personalised recommendations.

27 Jan 2025

MIT breakthrough enables fast and uniform protein labeling in 3D tissues

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility.

24 Jan 2025

Prehabilitation associated with fewer complications and improved recovery after surgery

Actively preparing for major surgery by exercising and improving diet (known as "prehabilitation") is associated with fewer complications, less time in hospital, and improved recovery and quality of life in adults, finds an analysis of clinical trials published by The BMJ today.

23 Jan 2025

New diagnostic device could enable at-home early bladder cancer detection

Innovative fluorescence-based diagnostic system identifies early-stage bladder cancer with 90% accuracy, utilizing untreated urine samples for at-home testing.

23 Jan 2025

Long-covid patients are frustrated that federal research hasn’t found new treatments

Erica Hayes, 40, has not felt healthy since November 2020 when she first fell ill with covid.

22 Jan 2025

New imaging protocol enhances visualization of rare bone marrow cells

Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to accurately identify rare LepR+ stromal cells.

21 Jan 2025

What drives acne relapse? New study explores isotretinoin outcomes

New research suggests that increasing cumulative isotretinoin dosage could significantly reduce acne recurrence and the need for retreatment, offering hope for long-term skin clarity.

20 Jan 2025

Mapping neuronal IL-1R1 expression reveals insights into brain function

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased states.

17 Jan 2025

Over 500 European patients diagnosed through groundbreaking genetic research

More than 500 European patients with unknown conditions have received a diagnosis through new genetic research.

17 Jan 2025

Aurox expands activity into North America

From Aurox Ltd 15 Jan 2025

New guidelines for correct use of biochemical indices of bone statuss published

The Joint International Osteoporosis Foundation (IOF) Working Group and the International Federation of Clinical Chemistry (IFCC) Committee on Bone Metabolism have published important updated guidelines for the correct use of biochemical indices of bone status.

10 Jan 2025

Most disease-causing mutations that swap amino acids do so by making proteins less stable

Research shows 60% of missense mutations destabilize proteins, linking protein folding to genetic diseases, including cataracts and neurological disorders.

10 Jan 2025

UK's drug payment disclosure system fails to protect patients and public trust

The UK's self-regulated system for disclosing payments from drug companies to healthcare professionals and organizations is failing to protect patients and public trust, according to a new analysis led by researchers at the University of Bath, UK and Lund University, Sweden published in BMJ Evidence-Based Medicine.

9 Jan 2025

Unraveling the molecular mechanisms of disease-causing mutations

Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the journal Nature. Unstable proteins are more likely to misfold and degrade, causing them to stop working or accumulate in harmful amounts inside cells.

9 Jan 2025