Nuclear Magnetic Resonance (NMR) News and Research

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Patients with normal lipoprotein(a) levels may retain risk of atherosclerosis due to elevated LDL-P number

LipoScience, Inc., an in vitro diagnostic company advancing patient care by developing high value proprietary clinical diagnostic tests using nuclear magnetic resonance (NMR) technology, today announced results from a clinical study demonstrating that patients with normal levels of lipoprotein(a) may retain significant risk of atherosclerosis due to an elevated low density lipoprotein particle (LDL-P) number.

2 Jun 2012

Lilly, Kowa announce results from PREVAIL U.S. study

Kowa Pharmaceuticals America, Inc. and Eli Lilly and Company today announced results of the PREVAIL U.S. study (Pitavastatin compaREd with praVAstatin In Lowering LDL-C in the U.S.) which evaluated the efficacy of LIVALO (pitavastatin) 4 mg compared with pravastatin 40 mg in reducing low-density lipoprotein cholesterol (LDL-C), the primary endpoint, as well as effects on other lipid parameters and lipoprotein particles in adult patients with primary hyperlipidemia or mixed dyslipidemia.

2 Jun 2012

New solid state NMR method can help visualize structure of proteins

A new method to reveal the structure of proteins could help researchers understand biological molecules - both those involved in causing disease and those performing critical functions in healthy cells.

20 Mar 2012

New medical education portal - Lipoprotein Perspectives - launched

LipoScience, Inc., an in vitro diagnostic company advancing patient care by developing high value proprietary clinical tests using nuclear magnetic resonance (NMR) technology, announced the launch of Lipoprotein Perspectives - a medical education portal featuring experts in clinical and preventive cardiology, endocrinology, and lipidology - at www.lipoprotein.org.

19 Mar 2012

NMR techniques shed new light on how pharma molecules adopt different polymorphic forms

Scientists at the University of Warwick have used state-of-the-art nuclear magnetic resonance (NMR) techniques to shed new light on how pharmaceutical molecules pack together in the solid state.

8 Mar 2012

Mayo researchers gain insights into function of histone chaperones

Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they have determined the 3-D structure and interactions of the histone chaperone Rtt106 down to the atomic details.

1 Mar 2012

Researcher have identified thirty one regions of genome associated with circulating metabolites

In a study to the genetic variance of human metabolism, researchers have identified thirty one regions of the genome that were associated with levels of circulating metabolites, i.e., small molecules that take part in various chemical reactions of human body.

30 Jan 2012

University of Southampton receives ERC grant to support research into enhanced NMR

New research from the University of Southampton could lead to enhanced MRI scans, producing brighter and more precise images, and potentially allowing the detection of cancerous cells before they cause health problems.

15 Dec 2011

Researchers uncover binding pocket of 'functional significance' in Ras oncoprotein

A drug discovery team at Genentech, Inc., has uncovered a chink in the molecular armor of Ras, the most commonly occurring oncogene, which is a gene that when mutated has the potential of causing cancer in humans.

5 Dec 2011

Psoriasis may alter cholesterol composition and decrease HDL function

Collaborative research from Perelman School of Medicine at the University of Pennsylvania has shown that psoriasis patients have an increased risk of heart attack, stroke and cardiovascular death, especially if the psoriasis is moderate to severe. Now, Penn researchers have discovered the potential underlying mechanism by which the inflammatory skin disease impacts cardiovascular health.

17 Nov 2011

Type 2 diabetics with low cholesterol may carry residual risk of cardiac events

LipoScience, Inc., an in-vitro diagnostic company advancing patient care in cardiovascular, metabolic and other diseases using an innovative and proprietary platform based on nuclear magnetic resonance (NMR) technology, recognizes a presentation of clinical data which suggests that type 2 diabetics with low non-HDL and low LDL cholesterol may carry residual risk of a cardiac event based on high LDL particle numbers.

16 Nov 2011

DNP effectively identifies structure of biological proteins in small samples

Researchers from Hull, Bristol and Frankfurt have shown that a new technique for identifying molecular structure can be used effectively on small samples of biological proteins, particularly proteins that are targeted for drug development.

15 Nov 2011

Berkeley Lab, Bruker partner to develop and distribute new structural biology methods

Bruker Corporation and Lawrence Berkeley National Laboratory (Berkeley Lab) today announced a collaboration to develop and distribute new structural biology methods and tools to integrate Small-Angle X-ray Scattering (SAXS) with Nuclear Magnetic Resonance.

11 Nov 2011

Young adults born prematurely show multiple biological signs of risks to future health

Young adults who were born prematurely show multiple biological signs of risks to future health, research from Imperial College London has found. The scientists, reporting their findings tomorrow in the journal Pediatric Research, say that the research indicates that urgent work is now needed to monitor preterm babies into adulthood to improve the detection of early signs of disease.

19 Oct 2011

Biochemists reveal interaction between tumor suppressor protein and chaperone

Every cell has thousands of proteins whose activity and lifetime must be regulated to control the cellular life cycle from cell division to cell death. The heat shock protein Hsp90 plays a key role in this process. It is a so-called chaperone, a quality controller, as it were. It monitors and controls the quality and activity of many important signal proteins and helps them take on the right form. When the cell is exposed to high stress levels from heat or a lack of oxygen, Hsp90 is produced in larger quantities to shield its partner proteins from damage.

8 Sep 2011

Researchers discover how yeast cells identify, attach to human tissue and cause infection

Researchers are a step closer towards creating a new class of medicines and vaccines to combat drug-resistant and deadly strains of fungal infections, following a new study published today in Proceedings of the National Academy of Sciences.

6 Sep 2011

New analytical method can develop specific drugs against parasites, bacteria

A team led by Professor Malcolm McConville from the Bio21 Institute, University of Melbourne developed a new analytical method which can be used for many infectious parasites and bacteria.

6 Aug 2011

Decline of citrate concentration may contribute to bone brittleness

Bone is one of nature's surprising "building materials." Pound-for-pound it's stronger than steel, tough yet resilient. Scientists at the U.S. Department of Energy's Ames Laboratory have identified the composition that gives bone its outstanding properties and the important role citrate plays, work that may help science better understand and treat or prevent bone diseases such as osteoporosis.

9 Jun 2011

Berkeley Lab scientists contribute to remarkable advance in nuclear magnetic resonance

Nuclear magnetic resonance, a scientific technique associated with outsized, very low temperature, superconducting magnets, is one of the principal tools in the chemist's arsenal, used to study everything from alcohols to proteins to such frontiers as quantum computing.

19 May 2011

LDL particles may be a more accurate measure of subclinical atherosclerosis than LDL cholesterol

LipoScience, Inc., a highly innovative diagnostic company that is advancing patient care by developing high value proprietary blood tests using nuclear magnetic resonance (NMR) technology, today announced presentations of two clinical studies "from the podium" at the 60th Annual Scientific Session of the American College of Cardiology.

6 Apr 2011