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Scientists develop CRISPRainbow to study genome structure in real time

CRISPRainbow, a new technology using CRISPR/Cas9 developed by scientists at UMass Medical School, allows researchers to tag and track up to seven different genomic locations in live cells. This labeling system, details of which were published in Nature Biotechnology, will be an invaluable tool for studying the structure of the genome in real time.

21 Apr 2016

Blocking IL-1 signalling molecule could alleviate asthma symptoms

Scientists have made a discovery that could lead to improved treatment for asthma sufferers.They have found that blocking a certain signalling molecule can alleviate symptoms such as mucus production, swelling (edema), and constriction of the airways in the lungs.

21 Apr 2016

Gladstone scientists bioengineer micro-scale heart tissues from stem cells

Scientists at the Gladstone Institutes have invented a new way to create three-dimensional human heart tissue from stem cells. The tissue can be used to model disease and test drugs, and it opens the door for a precision medicine approach to treating heart disease. Although there are existing techniques to make three-dimensional tissues from heart cells, the new method dramatically reduces the number of cells needed, making it an easier, cheaper, and more efficient system.

21 Apr 2016

Study shows beneficial effect of hNSC transplantation for TBI

Traumatic brain injury (TBI) is a major cause of mortality and morbidity, often causing lifelong disability for those who survive. Treatment is limited to supportive care, but stem cell therapy has received recent attention as a way to promote recovery for injuries to the central nervous system (CNS). In this study, researchers transplanted human neural stem cells (hNSCs) into the brains of mice modeled with TBI to investigate whether the hosts' immune systems and the stem cells acting in concert would enhance repair.

20 Apr 2016

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology.

19 Apr 2016

Researchers find way to attack a process that tumor cells use to escape effects of cancer drugs

Cancer cells often devise ways to survive even in the presence of toxic chemotherapy. Now, a research team led by investigators at Beth Israel Deaconess Medical Center has found a way to attack a process that tumor cells use to escape the effects of standard cancer drugs. The discovery is published online today in the journal Nature Cell Biology.

19 Apr 2016

Scientists discover new diagnostic marker for liver cancer

Scientists may have discovered a significant new diagnostic marker for liver cancer, according to a paper published in the April 18 online issue of Nature Cell Biology.

19 Apr 2016

Reducing hair loss during chemotherapy: an interview with Richard Paxman

The basic principle of chemotherapy is to damage the mitotic and metabolic processes in the cancer cells. The chemotherapy doesn't just target the cancer cells, it also targets the healthy cells, specifically ones that are rapidly dividing - our hair follicles are also rapidly dividing. We see damage to those hair cells, which then causes the hair to fall out.

From Paxman 19 Apr 2016

Studies confirm benefit of plasma genotyping to predict treatment outcomes for NSCLC patients

The benefit of plasma genotyping to predict treatment benefit in patients with non-small-cell lung cancer (NSCLC) is confirmed in three studies presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland. Researchers however warned that plasma tests are unlikely to fully replace tissue biopsies.

18 Apr 2016

Noise in concentration of vitamin A derivative RA can lead to disruptions in brain development

Using cutting-edge imaging technology, University of California, Irvine biologists have determined that uncontrolled fluctuations (known at "noise) in the concentration of the vitamin A derivative Retinoic acid (RA) can lead to disruptions in brain organization during development.

18 Apr 2016

FOXO proteins affect dozens of genes common to worms, flies, mice and humans

Whether a creature is a worm, a fly, a mouse, or a human, death inevitably awaits. And not only do these organisms share a common fate, but also, according to a new study, they may share some of the specific mechanisms of mortality. The researchers found that in all four species, there are 46 genes regulated by the same family of "FOXO" proteins known to be central in aging and longevity.

16 Apr 2016

Slow-wave sleep may promote consolidation of recent memories

Research strongly suggests that sleep, which constitutes about a third of our lives, is crucial for learning and forming long-term memories. But exactly how such memory is formed is not well understood and remains, despite considerable research, a central question of inquiry in neuroscience.

16 Apr 2016

Scientists aim to develop latest biosensors for personalized medicine, drug development

Scientists at the Leibniz Institute for Molecular Pharmacology in Berlin-Buch and the California Institute of Technology in Pasadena cooperate in the future for the development of the latest biosensors for usage related to personalized medicine and drug development.

14 Apr 2016

Combination of genetic, environmental risk factors can trigger fatal eating disorder in humans

In a new study, researchers from Columbia University Medical Center described a new mouse model featuring a combination of genetic and environmental risk factors that can trigger the compulsive restriction of food intake seen in patients with anorexia nervosa. The findings may help to identify new prevention and treatment strategies for the eating disorder in humans.

12 Apr 2016

Mouse-based study shows exercise decreases cancer incidence, slows tumor growth

When you're pounding along an icy pavement or sweating through a gym workout, you try to remind yourself of the many health benefits of exercise. Between gasps, you can say that a healthy, fit lifestyle helps prevents obesity, a worldwide problem of increasing magnitude that has been linked to cardiovascular disease and diabetes.

11 Apr 2016

Metabolic pathway activates cell signaling protein to promote breast cancer metastasis

A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology.

7 Apr 2016

Commonly used fungicides could cause gene expression changes in brain cells

Scientists at the UNC School of Medicine have found a class of commonly used fungicides that produce gene expression changes similar to those in people with autism and neurodegenerative conditions, including Alzheimer's disease and Huntington's disease.

31 Mar 2016

Qlucore’s Omics Explorer enables researchers to study genetic influences behind Li-Fraumeni Syndrome

While childhood cancer is rare (adult malignancies after 20 years are 20-30 times more common in general) it remains a major cause of death by disease in children. 15,700 children are diagnosed with cancer each year in the USA.

31 Mar 2016

KAIST researchers develop bio-medical imaging tool to view, analyze live cells

Professor YongKeun Park of the Physics Department at the Korea Advanced Institute of Science and Technology and his research team have developed a powerful method for 3D imaging of live cells without staining. The researchers announced the launch of their new microscopic tool, the holotomography (HT)-1, to the global marketplace through a Korean start-up that Professor Park co-founded, TomoCube.

29 Mar 2016

UC Berkeley biologists discover potential target for unisex contraceptives

UC Berkeley biologists have discovered the switch that triggers the power kick sperm use to penetrate and fertilize a human egg, uncovering a possible source of male infertility but also a potential target for contraceptives that work in both men and women.

26 Mar 2016

Cell Biology News and Research

Scientists develop CRISPRainbow to study genome structure in real time

Blocking IL-1 signalling molecule could alleviate asthma symptoms

Gladstone scientists bioengineer micro-scale heart tissues from stem cells

Study shows beneficial effect of hNSC transplantation for TBI

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Researchers find way to attack a process that tumor cells use to escape effects of cancer drugs

Scientists discover new diagnostic marker for liver cancer

Reducing hair loss during chemotherapy: an interview with Richard Paxman

Studies confirm benefit of plasma genotyping to predict treatment outcomes for NSCLC patients

Noise in concentration of vitamin A derivative RA can lead to disruptions in brain development

FOXO proteins affect dozens of genes common to worms, flies, mice and humans

Slow-wave sleep may promote consolidation of recent memories

Scientists aim to develop latest biosensors for personalized medicine, drug development

Combination of genetic, environmental risk factors can trigger fatal eating disorder in humans

Mouse-based study shows exercise decreases cancer incidence, slows tumor growth

Metabolic pathway activates cell signaling protein to promote breast cancer metastasis

Commonly used fungicides could cause gene expression changes in brain cells

Qlucore’s Omics Explorer enables researchers to study genetic influences behind Li-Fraumeni Syndrome

KAIST researchers develop bio-medical imaging tool to view, analyze live cells

UC Berkeley biologists discover potential target for unisex contraceptives

Event guide: 7th Allogeneic Cell Therapies Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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