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Troponin T test provides possible one hour diagnosis of heart attack

Results from the TRAPID-AMI clinical study have been published online by the Annals of Emergency Medicine, confirming a novel approach for a more rapid diagnosis of heart attack in patients with acute chest pain.

From Roche Sequencing and Life Science 15 Jan 2016

High Performance UV Assay Microplates

Krystal UV quartz bottomed microplates from Porvair Sciences Ltd. are designed for high throughput applications which require excitation or detection wavelengths in the far UV region below 350nm.

From Porvair Sciences Limited 14 Jan 2016

Estrogen may protect women against flu

The female sex hormone estrogen has anti-viral effects against the influenza A virus, commonly known as the flu, a new study in American Journal of Physiology—Lung Cellular and Molecular Physiology reports.

13 Jan 2016

New UTMB study reveals link between traumatic brain injury and Alzheimer's disease

A new study from The University of Texas Medical Branch at Galveston fills an important gap in understanding the link between traumatic brain injury and neurodegenerative disorders such as Alzheimer's disease.

13 Jan 2016

Pulmonary neuroendocrine cells act like sensor to orchestrate immune response

An uncommon and little-studied type of cell in the lungs has been found to act like a sensor, linking the pulmonary and central nervous systems to regulate immune response in reaction to environmental cues.

13 Jan 2016

Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Lewy bodies had been considered to be a key element of pathogenesis for Parkinson's disease. Although structural analysis for Lewy bodies with an electron microscope had been performed, it had no secondary structural information of proteins, which is important for the development of drugs.

13 Jan 2016

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Psychiatrists investigating depression have been energized in recent years by reports of rapid, successful treatment with drugs that interfere with the brain chemical glutamate, such as the anesthetic ketamine.

13 Jan 2016

Cornell researchers identify potent cancer-killing proteins that can kill tumors in bloodstream

Cornell researchers have discovered potent cancer-killing proteins that can travel by white blood cells to kill tumors in the bloodstream of mice with metastatic prostate cancer. The breakthrough study will be published Feb. 10 as the cover article in the Journal of Controlled Release.

13 Jan 2016

New mechanism of differentiation may offer novel therapeutic approaches to blood malignancies, solid tumors

In humans the differentiation of stem cells into hundreds of specialized cell types is vital. Differentiation drives development from fertilized egg to a newborn, and it underlies the continuous replacement of the 5 billion cells that die every hour in an adult. On the downside, mutations in differentiation pathways of different cell types can be drivers of cancers.

13 Jan 2016

IMB scientists identify two proteins vital for demethylation of DNA

Scientists at the Institute of Molecular Biology in Mainz have identified a missing piece of the puzzle in understanding how epigenetic marks are removed from DNA. The research on DNA demethylation sheds new light on a fundamental process that is important in development and diseases such as cancer.

12 Jan 2016

Three new genetic associations identified for primary open angle glaucoma

Researchers from Massachusetts Eye and Ear/Harvard Medical School and Case Western Reserve University School of Medicine have led an international effort to identify three genetic associations that influence susceptibility to primary open angle glaucoma -- the most common form of adult onset glaucoma and the leading cause of irreversible blindness in the world.

12 Jan 2016

MD Anderson-led study explores role of HIF-1 in triple-negative breast cancer

A multi-institutional international study led by scientists at The University of Texas MD Anderson Cancer Center has revealed new information about how molecules called long non-coding RNAs (lncRNA) interact with HIF-1, a signaling pathway that is overexpressed in many cancers. HIF-1 has been shown to regulate breast cancer progression.

12 Jan 2016

UCA researchers create new animal models to study link between diabetes and Alzheimer's disease

In recent time, many epidemiological studies have proved very close links existing between diabetes and Alzheimer´s disease. In fact, it has been stated that diabetes is a significant risk factor for suffering from Alzheimer and vascular dementia, the two main causes of dementia.

12 Jan 2016

GPR119 could be a potential treatment target for nonalcoholic fatty liver disease

New research published in the January 2016 issue of The FASEB Journal suggests that the G-protein-coupled receptor 119 (GPR119) could be a viable treatment target for nonalcoholic fatty liver disease. This receptor has already been identified as a drug target for diabetes and obesity, and this report raises hopes that compounds that target GPR119 for diabetes or obesity might also work for non-alcoholic fatty liver disease.

12 Jan 2016

Scientists discover protein interaction that describes aggressive subtype of medulloblastoma

Scientists at St. Jude Children's Research Hospital and the University of Würzburg in Germany have identified a protein interaction that is a hallmark of an aggressive subtype of medulloblastoma and that may provide a new treatment strategy.

12 Jan 2016

Clontech Laboratories launches Guide-it CRISPR/Cas9 Gesicle Production System

Clontech Laboratories, Inc., a wholly-owned subsidiary of Takara Bio Inc., today announced the launch of the Guide-it CRISPR/Cas9 Gesicle Production System. This system provides an innovative method to deliver Cas9/single guide RNA (sgRNA) ribonucleoprotein complexes to a broad range of cell types.

11 Jan 2016

Researchers describe three cleaning procedures that effectively remove, disassemble α-Syn fibrils

Lewy bodies and Lewy neurites are found in the brains of Parkinson's disease (PD) patients. They consist primarily of fibrils of the protein alpha-synuclein (α-Syn), which self-assembles into fibrils in vitro. If introduced into the human body, these seeds can act as prions and trigger the formation of toxic protein deposits. Because α-Syn fibrils are often used in research, it is important that they are not accidentally transferred to humans or cell cultures.

11 Jan 2016

Genetic factors in puberty timing: an interview with Dr John Perry

The study focused on the genetic regions that influence age at voice breaking - a distinct developmental milestone that happens to young men as their larynx (voice box) lengthens when exposed to male hormones.

11 Jan 2016

Finding may aid in the design of potential therapies for thyroid problems

Thyroid disease affects about 12 percent of the U.S. population. While many people with thyroid disease don't even know they have it, an overactive or underactive thyroid can cause a slew of problems, including weight gain or loss, mood changes and infertility. In children, an underactive thyroid can be fatal, which is why they are tested for a deficiency at birth.

11 Jan 2016

Blocking brain inflammation could protect against memory, behaviour changes

A University of Southampton-led study has found that blocking a receptor in the brain responsible for regulating immune cells could protect against the memory and behaviour changes seen in the progression of Alzheimer's disease.

11 Jan 2016

Protein C News and Research

Troponin T test provides possible one hour diagnosis of heart attack

High Performance UV Assay Microplates

Estrogen may protect women against flu

New UTMB study reveals link between traumatic brain injury and Alzheimer's disease

Pulmonary neuroendocrine cells act like sensor to orchestrate immune response

Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Cornell researchers identify potent cancer-killing proteins that can kill tumors in bloodstream

New mechanism of differentiation may offer novel therapeutic approaches to blood malignancies, solid tumors

IMB scientists identify two proteins vital for demethylation of DNA

Three new genetic associations identified for primary open angle glaucoma

MD Anderson-led study explores role of HIF-1 in triple-negative breast cancer

UCA researchers create new animal models to study link between diabetes and Alzheimer's disease

GPR119 could be a potential treatment target for nonalcoholic fatty liver disease

Scientists discover protein interaction that describes aggressive subtype of medulloblastoma

Clontech Laboratories launches Guide-it CRISPR/Cas9 Gesicle Production System

Researchers describe three cleaning procedures that effectively remove, disassemble α-Syn fibrils

Genetic factors in puberty timing: an interview with Dr John Perry

Finding may aid in the design of potential therapies for thyroid problems

Blocking brain inflammation could protect against memory, behaviour changes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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