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CUMC study reveals statins may help reduce heart disease risk in people with sleep apnea

A new study conducted at Columbia University Medical Center has revealed some of the underlying mechanisms that may increase the risk of heart disease in people with sleep apnea. The study also found that statins -- the cholesterol-lowering medications commonly prescribed to combat heart disease -- may help reverse this process.

7 Jan 2016

Discovery may pave way for more effective treatments for pandemics, seasonal flu

Scientists at Imperial College London have discovered how flu viruses 'hijack' cell machinery when they infect the body. The findings, published in the journal Nature, may pave the way for more effective antiviral treatments for pandemics and for seasonal flu, which infects over 800 million people worldwide every year.

7 Jan 2016

Combining NELL-1 with BMP2 therapy may promote bone development

Bone morphogenetic protein-2 (BMP2) is used clinically to promote bone repair. However, the high BMP2 concentrations required to stimulate bone growth in humans may produce life-threatening adverse effects such as cervical swelling in spinal fusion procedures, a problem that prompted an FDA warning in 2008.

7 Jan 2016

UF researchers reveal link between chronic stress and fat metabolism

In cell and mouse model experiments, University of Florida Health researchers have discovered that chronic stress stimulates production of betatrophin, a protein that then goes on to inhibit an enzyme involved in fat metabolism.

7 Jan 2016

Leukaemia drug could slow progression of Duchenne muscular dystrophy

A drug commonly used to treat leukaemia is showing potential as a treatment that could slow the progression of the muscle-wasting condition, Duchenne muscular dystrophy.

6 Jan 2016

New TAU study offers tangible hope of curing Mantle Cell Lymphoma

With a median survival rate of just five to seven years, Mantle Cell Lymphoma (MCL) is considered the most aggressive known blood cancer -- and available therapies are scarce. Three thousand Americans are diagnosed with MCL every year, and despite progress in personalized therapies to treat metastases elsewhere in the body, systemic therapeutic drug delivery to cancerous blood cells continues to challenge the world of cancer research.

6 Jan 2016

UNC researchers uncover new potential strategy to kill cancerous cells in the brain

Rapidly dividing cells rely on an enzyme called Dicer to help them repair the DNA damage that occurs as they make mistakes in copying their genetic material over and over for new cells. UNC Lineberger Comprehensive Cancer Center researchers have built on the discovery of Dicer's role in fixing DNA damage to uncover a new potential strategy to kill rapidly dividing, cancerous cells in the brain.

6 Jan 2016

Researchers identify mechanism that allows cancer cells to grow rapidly when blood sugar levels rise

Researchers have identified a mechanism that allows cancer cells to respond and grow rapidly when levels of sugar in the blood rise. This may help to explain why people who develop conditions in which they have chronically high sugar levels in their blood, such as obesity, also have an increased risk of developing certain types of cancer.

6 Jan 2016

Study may hold new revelations about how stress during pregnancy affects mothers and offspring

The sequencing of the first genome involving a cockroach species may one day serve as a model system comparable to how research on mice can apply to humans. In this case, the model could hold new revelations about how stress during pregnancy could affect both the mother and her offspring.

6 Jan 2016

Scientists demonstrate workings of CCL2 mechanism that stimulates nerve regeneration

The peripheral nervous system is a vast network of nerves that exists primarily outside of brain and spinal cord and connects to the far reaches of the body. The very expanse of peripheral nerves makes them highly vulnerable to injuries such as blunt-force blows, cuts, and leg and arm fractures, as well as diseases that attack peripheral nerves such as diabetes, Charcot-Marie-Tooth, and Guillain-Barre syndrome.

6 Jan 2016

Alpha-synuclein protein involved in Parkinson's disease pathology does not behave like a 'prion'

In Parkinson's disease, the protein "alpha-synuclein" aggregates within neurons of patients and appears to propagate across interconnected areas of the brain. How this happens remains largely unknown.

6 Jan 2016

SillaJen reports initiation of multinational randomized Phase 3 study of Pexa-Vec in HCC patients

SillaJen, Inc., a private, clinical-stage, biotherapeutics company focused on the development of oncolytic immunotherapy products for cancer, has announced the initiation of a multinational randomized Phase 3 open-label study of its lead product candidate, Pexa-Vec (formerly JX-594), in patients with advanced liver cancer, also known as hepatocellular carcinoma (HCC).

5 Jan 2016

FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

Ionis Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration has granted Orphan Drug Designation to IONIS-HTTRx for the treatment of patients with Huntington's disease (HD).

5 Jan 2016

Scripps biologist describes major advancement in flu vaccine research

Every fall, millions of people roll up their sleeves to get a flu shot. Up to 20 percent of the population gets the flu and more than 200,000 people are hospitalized with flu complications each year, according to the U.S. Centers for Disease Control and Prevention. While seasonal vaccines provide some protection, they are not always effective because the strains of influenza virus in the vaccine may not be well matched to the flu viruses circulating that year. So researchers are searching for a way to develop a more universal vaccine that would be effective against any variety of influenza.

5 Jan 2016

UNC-Chapel Hill study links social relationships with better health

The more social ties people have at an early age, the better their health is at the beginnings and ends of their lives, according to a new study from the University of North Carolina at Chapel Hill.

5 Jan 2016

Children conceived through infertility treatments no more likely to have developmental delays

Children conceived via infertility treatments are no more likely to have a developmental delay than children conceived without such treatments, according to a study by researchers at the National Institutes of Health, the New York State Department of Health and other institutions.

5 Jan 2016

Antiscarring paste can halt fibrosis caused by radiation treatment

An antiscarring paste when applied to the skin of mice halts fibrosis caused by the radiation used in cancer therapy. That is according to a study led by researchers at Laura and Isaac Perlmutter Cancer Center to be published tomorrow in the January edition of the Journal of the Federation of American Societies for Experimental Biology, or FASEB.

5 Jan 2016

Researchers discover methods for reducing age-related stem cell dysfunction, metabolic disease in aged mice

Mayo Clinic researchers have taken what they hope will be the first step toward preventing and reversing age-related stem cell dysfunction and metabolic disease. That includes diabetes, which affects 12.2 million Americans age 60 and older, according to the National Council on Aging.

5 Jan 2016

High diversity among circulating tumor cells predicts survival, treatment resistance in prostate cancer patients

Research teams at Memorial Sloan Kettering Cancer Center and Epic Sciences have found that greater diversity among circulating tumor cells (CTCs) in the blood of advanced prostate cancer patients predicts not only shorter overall survival, but also the development of resistance to key anti-androgen therapies.

4 Jan 2016

UT Southwestern scientists use new gene-editing technique to prevent progression of DMD in young mice

Using a new gene-editing technique, a team of scientists from UT Southwestern Medical Center stopped progression of Duchenne muscular dystrophy (DMD) in young mice.

4 Jan 2016

Protein C News and Research

CUMC study reveals statins may help reduce heart disease risk in people with sleep apnea

Discovery may pave way for more effective treatments for pandemics, seasonal flu

Combining NELL-1 with BMP2 therapy may promote bone development

UF researchers reveal link between chronic stress and fat metabolism

Leukaemia drug could slow progression of Duchenne muscular dystrophy

New TAU study offers tangible hope of curing Mantle Cell Lymphoma

UNC researchers uncover new potential strategy to kill cancerous cells in the brain

Researchers identify mechanism that allows cancer cells to grow rapidly when blood sugar levels rise

Study may hold new revelations about how stress during pregnancy affects mothers and offspring

Scientists demonstrate workings of CCL2 mechanism that stimulates nerve regeneration

Alpha-synuclein protein involved in Parkinson's disease pathology does not behave like a 'prion'

SillaJen reports initiation of multinational randomized Phase 3 study of Pexa-Vec in HCC patients

FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

Scripps biologist describes major advancement in flu vaccine research

UNC-Chapel Hill study links social relationships with better health

Children conceived through infertility treatments no more likely to have developmental delays

Antiscarring paste can halt fibrosis caused by radiation treatment

Researchers discover methods for reducing age-related stem cell dysfunction, metabolic disease in aged mice

High diversity among circulating tumor cells predicts survival, treatment resistance in prostate cancer patients

UT Southwestern scientists use new gene-editing technique to prevent progression of DMD in young mice

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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