Protein C News and Research

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World's largest database for cancer drug discovery revolutionised by 3D techniques

THE world's largest database for cancer drug discovery has been revolutionised by adding 3D structures of faulty proteins and maps of cancer's communication networks, according to Cancer Research UK-funded research published in Nucleic Acid Research today (Monday).

4 Jan 2016

NCCLC patients with KRAS-related gene mutations may benefit from triple therapy

Although the most common type of lung cancer - non-small cell lung cancer (NSCLC) - has recently seen major treatment advances in some genetic subtypes, other subtypes continue to evade effective treatment. (New therapies exist for NCCLC patients whose cancers harbor mutations in the ALK or EGFR genes, for example.)

4 Jan 2016

New Penn study shows that social behavior in carpenter ants can be reprogrammed

In Florida carpenter ant colonies, distinct worker castes called minors and majors exhibit pronounced differences in social behavior throughout their lives. In a new study published today in Science, a multi-institution team anchored at University of Pennsylvania found that these caste-specific behaviors are not set in stone.

4 Jan 2016

Researchers successfully use CRISPR to treat adult mouse model of Duchenne muscular dystrophy

Researchers have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy. This marks the first time that CRISPR has successfully treated a genetic disease inside a fully developed living mammal with a strategy that has the potential to be translated to human therapy.

4 Jan 2016

MUSC researchers receive $1.68 million NIH grant to study better treatment for chronic pancreatitis, diabetes

MUSC researchers received a $1.68 million National Institutes of Health grant to explore a better treatment for chronic pancreatitis, with the hopes that it also may shed light on a future cure for patients with type 1 diabetes.

4 Jan 2016

Processed foods may increase likelihood of developing autoimmune diseases

In today's hustle and bustle world, processed foods are commonplace time-savers. But that convenience factor may come with a bigger price tag than previously known, says an international team of researchers.

31 Dec 2015

3-D recordings of nematode brains may help understand how neurons coordinate action and perception

Princeton University researchers have captured among the first recordings of neural activity in nearly the entire brain of a free-moving animal. The three-dimensional recordings could provide scientists with a better understanding of how neurons coordinate action and perception in animals.

31 Dec 2015

Therapies that boost anti-HER2 immunity may help reduce risk of HER2-positive breast cancer recurrence

Recurrence of HER2-positive breast cancer after treatment may be due to a specific and possibly cancer-induced weakness in the patient's immune system -- a weakness that in principle could be corrected with a HER2-targeted vaccine -- according to a new study from the Perelman School of Medicine at the University of Pennsylvania.

31 Dec 2015

ORNL's cell-free protein synthesis system can help save lives of soldiers injured in remote locations

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the Department of Energy's Oak Ridge National Laboratory.

30 Dec 2015

St. Jude scientists develop interactive tool to advance understanding of mutations that fuel pediatric cancer

St. Jude Children's Research Hospital scientists have developed a web application and data set that gives researchers worldwide a powerful interactive tool to advance understanding of the mutations that lead to and fuel pediatric cancer. The freely available tool, called ProteinPaint, is described in today's issue of the scientific journal Nature Genetics.

30 Dec 2015

Myostatin antibody shows promise in treating age-related decline in muscle mass and power

A proof-of-concept, phase 2 trial by an international research team has found promising results for a myostatin antibody in treating the decline in muscle mass and power associated with aging.

29 Dec 2015

Scientists pin down structure of neuronal protein clumps associated with ALS

To create treatments for a disease without any, scientists need to study and understand the driving forces behind the faulty biology. Today, researchers at the University of North Carolina School of Medicine announced the first-ever evidence-based description of the neuronal protein clumps thought to be important in Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, a fatal neurodegenerative condition.

29 Dec 2015

New study identifies activity of brain proteins linked to memory impairments in Alzheimer's disease

A new study conducted at the University of Haifa and published recently in the Journal of Neuroscience has identified activity of brain proteins associated with memory impairments in Alzheimer's disease, and has also found that "repairing" this activity leads to an improvement in memory.

29 Dec 2015

Body can control pathogen-induced inflammatory response, find Georgia State researchers

The body can control inflammatory response triggered by invasions of microbial pathogens, such as bacteria and viruses, a discovery that could lead to the development of new therapeutic agents for uncontrolled inflammation, according to researchers at Georgia State University.

29 Dec 2015

Infusing small dose of cytokine can prevent or reverse diabetes-related kidney failure

Diabetes is the leading cause of kidney failure, and scientists have found that infusing just a small dose of a cytokine, thought to help cause that failure, can instead prevent or reverse it.

29 Dec 2015

Researchers identify new gene that helps maintain chromosome number in cells

Molecular biologists at UT Southwestern Medical Center have identified a gene called NORAD that helps maintain the proper number of chromosomes in cells, and that when inactivated, causes the number of chromosomes in a cell to become unstable, a key feature of cancer cells.

26 Dec 2015

Researchers identify liver-derived hormone that regulates sugar intake

We all love our sugar, especially during the holidays. Cookies, cake, and candy are simply irresistible. While sugar cravings are common, the physiological mechanisms that trigger our "sweet tooth" are not well defined.

24 Dec 2015

Study directly links common variants of Alzheimer's risk genes to atrophy

Two genetic variants previously linked to Alzheimer's disease have been more specifically tied to brain atrophy that is characteristic of the disease.

24 Dec 2015

Novel antibody improves glucose regulation and reduces fatty liver in obese mice

A new study by researchers from Harvard T.H. Chan School of Public Health and colleagues describes the pre-clinical development of a therapeutic that could potentially be used to treat type 2 diabetes, fatty liver disease, and other metabolic diseases.

24 Dec 2015

Eating at the wrong time of day affects learning and memory

An occasional late-night raid on turkey leftovers might be harmless but new research with mice suggests that making a habit of it could alter brain physiology.

24 Dec 2015

Protein C News and Research

World's largest database for cancer drug discovery revolutionised by 3D techniques

NCCLC patients with KRAS-related gene mutations may benefit from triple therapy

New Penn study shows that social behavior in carpenter ants can be reprogrammed

Researchers successfully use CRISPR to treat adult mouse model of Duchenne muscular dystrophy

MUSC researchers receive $1.68 million NIH grant to study better treatment for chronic pancreatitis, diabetes

Processed foods may increase likelihood of developing autoimmune diseases

3-D recordings of nematode brains may help understand how neurons coordinate action and perception

Therapies that boost anti-HER2 immunity may help reduce risk of HER2-positive breast cancer recurrence

ORNL's cell-free protein synthesis system can help save lives of soldiers injured in remote locations

St. Jude scientists develop interactive tool to advance understanding of mutations that fuel pediatric cancer

Myostatin antibody shows promise in treating age-related decline in muscle mass and power

Scientists pin down structure of neuronal protein clumps associated with ALS

New study identifies activity of brain proteins linked to memory impairments in Alzheimer's disease

Body can control pathogen-induced inflammatory response, find Georgia State researchers

Infusing small dose of cytokine can prevent or reverse diabetes-related kidney failure

Researchers identify new gene that helps maintain chromosome number in cells

Researchers identify liver-derived hormone that regulates sugar intake

Study directly links common variants of Alzheimer's risk genes to atrophy

Novel antibody improves glucose regulation and reduces fatty liver in obese mice

Eating at the wrong time of day affects learning and memory

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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