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Cancer cells co-opt pain-sensing 'neural channel' to increase tolerance against oxidative stress

Anyone who's taken a bite of a sandwich with too much spicy mustard or a piece of sushi with too much wasabi can attest to the tear-inducing sensation these condiments can cause. These loud warnings to the nervous system of exposure to potentially harmful chemicals are triggered by TRPA1, a calcium channel protein sometimes referred to as the "wasabi receptor."

25 May 2018

Study links cell size with commitment to division

How does a cell know when to divide? We know that hundreds of genes contribute to a wave of activity linked to cell division, but to generate that wave new research shows that cells must first grow large enough to produce four key proteins in adequate amounts.

24 May 2018

Study provides blueprint of how fruit flies can be used to screen potentially pathogenic human genes

It all began with one young patient; a 7-year old boy who was born without a thymus, an important organ of the immune system, and without functional immune cells. The boy also presented with cardiac and skeletal defects, dysmorphic craniofacial features and some signs of autistic behaviors.

23 May 2018

Scientists decipher workings of little-understood bacterial riboswitch

In a discovery that points to potential new antibiotic medicines, scientists from Rice University and the University of Michigan have deciphered the workings of a common but little-understood bacterial switch that cuts off protein production before it begins.

22 May 2018

Researchers push science one step closer to growing body parts in a lab

Researchers have learned that precursor cells for skeletal muscles actually also give rise to neurons, blood vessels, blood cells and immune cells, pushing science one step closer to generating body parts in a laboratory.

17 May 2018

New study could have important implications for cellular aging

Researchers have found a way to stimulate autophagy, a process used by cells to convert misfolded proteins and redundant organelles into components that the cell can re-use.

16 May 2018

Researchers demonstrate new strategy for stimulating autophagy

Brown University researchers studying the biology of aging have demonstrated a new strategy for stimulating autophagy, the process by which cells rebuild themselves by recycling their own worn-out parts.

16 May 2018

Study finds distinct exhausted T cells that could have implications for fighting different diseases

The battle between the human immune system and long-term, persisting infections and other chronic diseases such as cancer results in a prolonged stalemate

16 May 2018

Biologists determine how transcription factors function differently in embryonic development

A team of biologists has determined how transcription factors (TFs), which guide gene regulation, function differently in embryonic development.

16 May 2018

Researchers discover unique mechanism that regulates tumor growth in lung cancer

Lung cancer is the third most common type of cancer in Germany and the disease affects both men and women. However, immunotherapies are successful in only 20 percent of cases.

14 May 2018

Scientists discover a mechanism through which HIV determines the fate and function of cells

A stem cell is one with infinite possibilities. So, for decades, scientists have puzzled over how the cell chooses to keep being a stem cell and continue dividing, or specialize into a specific cell type, like a heart or brain cell.

11 May 2018

Enhancing the effects of vitamin D to curb type 2 diabetes

More than 27 million people in the United States are living with type 2 diabetes, according to the Centers for Disease Control and Prevention. As the population ages and a growing percentage of people become overweight or obese, that number is expected to increase.

10 May 2018

Researchers devise neuronal cookbook for turning skin cells into different types of neurons

Scientists at The Scripps Research Institute have devised what they call a "neuronal cookbook" for turning skin cells into different types of neurons.

10 May 2018

ONC201 disrupts mitochondrial function and kills breast cancer cells, reveals study

TRAIL, a member of the TNF family of ligands, causes caspase-dependent apoptosis through activation of its receptors, death receptor 4 and DR5.

9 May 2018

New findings point to potential therapeutic avenues for leukemia

Scientists have known for decades that the Hox family of transcription factors are key regulators in the formation of blood cells and the development of leukemia.

9 May 2018

EPO's neuroprotective effect in preemies may be mediated by epigenetic regulation of genes

Erythropoietin helps to protect and repair vulnerable brains though it remains a mystery how the anemia drug does so.

7 May 2018

Discovery could be used as starting point for development of new antibiotics

According to the WHO, around 700,000 people die every year as a result of antibiotic resistance. In Germany, around 6,000 people die every year because treatment with antibiotics is not effective.

7 May 2018

Genes that control the immune system may play role in hair graying

A study has found a link between genes that warn our bodies of a pathogenic infection and genes that play a role in determining hair color.

4 May 2018

Scientists discover mechanism behind unusual form of tissue regeneration in the liver

By studying a rare liver disease called Alagille syndrome, scientists from Cincinnati Children's and the University of California San Francisco (UCSF) have discovered the mechanism behind an unusual form of tissue regeneration that may someday reduce the need for expensive and difficult-to-obtain organ transplants.

3 May 2018

Research findings challenge feasibility of 'shock and kill' approach to cure HIV

Researchers have provided new insight into the cellular processes behind the 'shock and kill' approach to curing HIV, which they say challenges the effectiveness of the treatment.

2 May 2018

Transcription News and Research

Cancer cells co-opt pain-sensing 'neural channel' to increase tolerance against oxidative stress

Study links cell size with commitment to division

Study provides blueprint of how fruit flies can be used to screen potentially pathogenic human genes

Scientists decipher workings of little-understood bacterial riboswitch

Researchers push science one step closer to growing body parts in a lab

New study could have important implications for cellular aging

Researchers demonstrate new strategy for stimulating autophagy

Study finds distinct exhausted T cells that could have implications for fighting different diseases

Biologists determine how transcription factors function differently in embryonic development

Researchers discover unique mechanism that regulates tumor growth in lung cancer

Scientists discover a mechanism through which HIV determines the fate and function of cells

Enhancing the effects of vitamin D to curb type 2 diabetes

Researchers devise neuronal cookbook for turning skin cells into different types of neurons

ONC201 disrupts mitochondrial function and kills breast cancer cells, reveals study

New findings point to potential therapeutic avenues for leukemia

EPO's neuroprotective effect in preemies may be mediated by epigenetic regulation of genes

Discovery could be used as starting point for development of new antibiotics

Genes that control the immune system may play role in hair graying

Scientists discover mechanism behind unusual form of tissue regeneration in the liver

Research findings challenge feasibility of 'shock and kill' approach to cure HIV

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Expanding research and clinical options for children with cancer

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