Protein C News and Research

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Researchers identify new target for novel immune-oncology treatments

By studying a type of immune cells, a team of researchers at the IRCM led by André Veillette, MD, identified the mechanism of action for a new target for novel immune-oncology treatments. Their discovery is published today in the print edition of the scientific journal the Journal of Experimental Medicine.

17 Nov 2015

Drug prevents onset of cognitive and cellular effects in mouse model of Alzheimer’s disease

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long-term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

17 Nov 2015

Improved gene therapy treatment shows promise in mice with cystic fibrosis

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular Virology and Gene Therapy at KU Leuven, Belgium.

17 Nov 2015

FDA grants accelerated approval for Darzalex to treat patients with multiple myeloma

Today the U.S. Food and Drug Administration granted accelerated approval for Darzalex (daratumumab) to treat patients with multiple myeloma who have received at least three prior treatments. Darzalex is the first monoclonal antibody approved for treating multiple myeloma.

17 Nov 2015

Research collaboration aims to develop new drug for slow-healing chronic wounds

The biotech company Omnio based in Swedish Umeå, and led by researcher Tor Ny at Umeå University, launches a research collaboration with the Canadian pharmaceutical company ProMetic to develop a new drug for slow-healing chronic wounds. The collaboration includes funding for clinical studies of a drug based on the blood plasma protein plasminogen.

15 Nov 2015

FDA grants accelerated approval for Tagrisso to treat patients with advanced NSCLC

Today, the U.S. Food and Drug Administration granted accelerated approval for an oral medication to treat patients with advanced non-small cell lung cancer (NSCLC). Tagrisso (osimertinib) is now approved for patients whose tumors have a specific epidermal growth factor receptor (EGFR) mutation (T790M) and whose disease has gotten worse after treatment with other EGFR-blocking therapy.

14 Nov 2015

Pathophysiological biomarkers predict PAH prognosis

Researchers have identified three biomarkers that signify an increased risk of death or requirement for lung transplantation in patients with pulmonary arterial hypertension.

13 Nov 2015

EU-funded research project aims to reduce oxidation in processed meat products

An EU-funded research project is to make sausages, patties and other meat products healthier in the future. Researchers at Lund University in Sweden, the Swedish University of Agricultural Sciences (SLU) and four other European research institutions have launched a joint project to reduce the risk of colon cancer - the most common cancer of the gastrointestinal tract in Sweden.

13 Nov 2015

Analyzing potential TB vaccine

When results from a landmark tuberculosis vaccine trial in Cape Town, South Africa were published in The Lancet in February 2013, the headlines were grim, despite hopes that the trial would point toward a successful way to thwart one of the globe's biggest public health threats.

13 Nov 2015

Research identifies liver pathway that contributes to negative effects of high-fat, high-cholesterol junk food diet

It's no secret that a high-fat, high-cholesterol "junk food" diet has been linked to major health problems, including high blood cholesterol and the buildup of plaques in the arteries, known as atherosclerosis.

13 Nov 2015

Cornell biomedical engineers develop 'super natural killer cells' to destroy cancer cells in lymph nodes

Cornell biomedical engineers have developed specialized white blood cells - dubbed "super natural killer cells" - that seek out cancer cells in lymph nodes with only one purpose: destroy them.

13 Nov 2015

Researchers find molecular mechanism that may be responsible for development of amyloidoses

A team of local researchers has proposed a molecular mechanism that may be responsible for the development of life-threatening diseases called amyloidoses. The best known of such diseases is Alzheimer's disease (AD), but there are many others that are receiving increased scrutiny, in part because of mounting evidence linking them to atherosclerosis and aging.

13 Nov 2015

Study highlights possible inaccuracies in thyroid cancer detection tests

Protein biomarkers are used to test for cancer before and after surgeries to remove tumors. To test thyroid malignancy, many biomarkers are tested separately to confirm cancer. However, new research from Michigan Technological University shows that the detection tests that measure two major biomarkers to diagnose thyroid cancer may be inaccurate.

13 Nov 2015

Presence of connexin proteins suppresses primary tumor growth

How does a protein called connexin put the clamps on cancer? Researchers in the School of Medicine at The University of Texas Health Science Center at San Antonio today reported an explanation.

13 Nov 2015

Study: Eating sweet foods causes the brain to form memories that may control eating behaviors

Eating sweet foods causes the brain to form a memory of a meal, according to researchers at Georgia State University, Georgia Regents University and Charlie Norwood VA Medical Center.

13 Nov 2015

TGen: PPF drug could help treat patients with deadly brain cancer

In a significant breakthrough, the Translational Genomics Research Institute has identified a drug, propentofylline or PPF, that could help treat patients with deadly brain cancer.

13 Nov 2015

New study refutes increased cancer risk for patients undergoing spinal fusion surgery with rhBMP

A new study may alleviate concerns regarding increased cancer risk for patients undergoing spinal fusion surgery with recombinant human bone morphogenetic protein (rhBMP). The study appears in November 15 issue of Spine, published by Wolters Kluwer.

13 Nov 2015

Drug combination produces long-term responses in patients with mantle cell lymphoma

New research from Moffitt Cancer Center and its collaborators find that the drug combination rituximab plus lenalidomide was effective and produced long-term responses in patients with mantle cell lymphoma.

13 Nov 2015

Mayo Clinic's Florida campus awarded NIH grant to identify vascular risk factors in aging and dementia

Mayo Clinic's Florida campus was awarded a $5.3 million grant from the National Institutes of Health to identify vascular risk factors in aging and dementia, and translate that knowledge into studying potential targets for treatment.

12 Nov 2015

Meta-analysis supports that intake of tree nuts lowers risk of cardiovascular disease

In a study published yesterday in the American Journal of Clinical Nutrition*, researchers performed a systematic review and meta-analysis of controlled trials to investigate the effects of tree nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts) on blood lipids, lipoproteins, blood pressure and inflammation in adults 18 years and older without prevalent cardiovascular disease (CVD).

12 Nov 2015

Protein C News and Research

Researchers identify new target for novel immune-oncology treatments

Drug prevents onset of cognitive and cellular effects in mouse model of Alzheimer’s disease

Improved gene therapy treatment shows promise in mice with cystic fibrosis

FDA grants accelerated approval for Darzalex to treat patients with multiple myeloma

Research collaboration aims to develop new drug for slow-healing chronic wounds

FDA grants accelerated approval for Tagrisso to treat patients with advanced NSCLC

Pathophysiological biomarkers predict PAH prognosis

EU-funded research project aims to reduce oxidation in processed meat products

Analyzing potential TB vaccine

Research identifies liver pathway that contributes to negative effects of high-fat, high-cholesterol junk food diet

Cornell biomedical engineers develop 'super natural killer cells' to destroy cancer cells in lymph nodes

Researchers find molecular mechanism that may be responsible for development of amyloidoses

Study highlights possible inaccuracies in thyroid cancer detection tests

Presence of connexin proteins suppresses primary tumor growth

Study: Eating sweet foods causes the brain to form memories that may control eating behaviors

TGen: PPF drug could help treat patients with deadly brain cancer

New study refutes increased cancer risk for patients undergoing spinal fusion surgery with rhBMP

Drug combination produces long-term responses in patients with mantle cell lymphoma

Mayo Clinic's Florida campus awarded NIH grant to identify vascular risk factors in aging and dementia

Meta-analysis supports that intake of tree nuts lowers risk of cardiovascular disease

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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