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Researchers pinpoint mechanisms that cause chemoresistance in ovarian cancer patients

Resistance to chemotherapy is a major problem for those suffering from ovarian cancer--a problem that prevents a cure from a disease dubbed the "silent killer." University of Georgia researchers are giving patients new hope with recent findings that help pinpoint the mechanisms causing chemoresistance.

27 Oct 2015

MGH researchers identify mechanism behind the spread of neurofibrillary tangles

Massachusetts General Hospital investigators have discovered a mechanism behind the spread of neurofibrillary tangles - one of the two hallmarks of Alzheimer's disease - through the brains of affected individuals.

27 Oct 2015

Ipsen, EpiVax partner to create next generation botulinum neurotoxin and TSI therapeutics

Ipsen and the US company EpiVax, Inc. today announced that they have completed a collaborative project that provides a novel approach for creating next generation botulinum neurotoxin (BoNT) and Targeted Secretion Inhibitor (TSI) therapeutics.

27 Oct 2015

Scientists find way to produce industrial quantities of beneficial natural compounds in tomatoes

Scientists at the John Innes Centre have found a way to produce industrial quantities of useful natural compounds efficiently, by growing them in tomatoes.

26 Oct 2015

Scalable production of gene therapy vectors: an interview with Frank Ubags

Gene therapy involves introducing genetic material into cells to replace missing or malfunctioning genes or to add a gene to express a beneficial protein in order to treat certain diseases, such as cancer or inherited disorders.

26 Oct 2015

New approaches to treating lung cancer patients in New Mexico

This year, more than 158,000 Americans are expected to die from lung cancer. That's a staggering number: it's more than all the deaths expected from breast, prostate, colon, rectum, bladder and skin cancers combined.

26 Oct 2015

UW researchers develop new model to more accurately predict harmful genetic mutations

Between any two people, there are likely to be at least 10 million differences in the genetic sequence that makes up their DNA.

26 Oct 2015

Novel method for examining small molecules may provide platform for new drug design

Most pharmaceutical drugs consist of tiny molecules, which target a class of proteins found on the surfaces of cell membranes. Studying these subtle interactions is essential for the design of effective drugs, but the task is extremely challenging.

26 Oct 2015

First computational method based on evolutionary principles developed to predict protein dynamics

Researchers from the Structural Biology Computational Group of the Spanish National Cancer Research Centre, led by Alfonso Valencia, in collaboration with a group headed by Francesco Gervasio at the University College London (UK), have developed the first computational method based on evolutionary principles to predict protein dynamics, which explains the changes in the shape or dimensional structure that they experience in order to interact with other compounds or speed up chemical reactions.

26 Oct 2015

New DNA study may lead to better treatments for diseases caused by cellular changes

Researchers at the University of Copenhagen have located a previously unknown function in the so-called histones, which allows for an improved understanding of how cells protect and repair DNA damages. This knowledge may eventually result in better treatments for diseases such as cancer.

26 Oct 2015

FDA approves Yondelis (trabectedin) for treatment of specific soft tissue sarcomas

The U.S. Food and Drug Administration today approved Yondelis (trabectedin), a chemotherapy, for the treatment of specific soft tissue sarcomas (STS) – liposarcoma and leiomyosarcoma – that cannot be removed by surgery (unresectable) or is advanced (metastatic).

24 Oct 2015

Improved results yielded from new ChIP-seq protocol

Chromatrap®, a business unit of Porvair Sciences, has developed a new protocol that further extends the many advantages of its popular Chromatin Immunoprecipitation Sequencing (ChIP-seq) assay kits.

From Chromatrap® - Porvair Sciences Ltd 23 Oct 2015

MU researchers successfully treat dogs with DMD, plan for human clinical trials

Muscular dystrophy, which affects approximately 250,000 people in the U.S., occurs when damaged muscle tissue is replaced with fibrous, fatty or bony tissue and loses function. For years, scientists have searched for a way to successfully treat the most common form of the disease, Duchenne Muscular Dystrophy (DMD), which primarily affects boys. Now, a team of University of Missouri researchers have successfully treated dogs with DMD and say that human clinical trials are being planned in the next few years.

23 Oct 2015

Potential new drug target for acute myeloid leukemia

New treatment options are badly needed for acute myeloid leukemia, a relatively rare form of cancer. The malignancy begins in the bone marrow, and from there can spread rapidly to the bloodstream, depriving the body of the essential blood cells that carry oxygen and fight infections.

23 Oct 2015

JDRF-funded study aims to find new types of diagnostic markers for diabetic kidney disease

In an effort to pinpoint the earliest signs of diabetic kidney disease, researchers at University of California, San Diego School of Medicine are leading a multi-institutional international effort dedicated to finding a new breed of disease indicators.

23 Oct 2015

Drug engineered from bananas could fight off wide range of viruses

A banana a day may not keep the doctor away, but a substance originally found in bananas and carefully edited by scientists could someday fight off a wide range of viruses, new research suggests.

23 Oct 2015

Researchers reveal why malaria vaccine provides only moderate protection among vaccinated children

Using new, highly sensitive genomic sequencing technology, an international team of researchers has found new biological evidence to help explain why the malaria vaccine candidate RTS,S/AS01 (called RTS,S) provided only moderate protection among vaccinated children during clinical testing.

23 Oct 2015

New drug delivery method could be used to target cancer, tuberculosis

Scientists have designed a novel method for improving the delivery of therapeutic molecules into diseased cells such as those found in cancer and tuberculosis.

23 Oct 2015

Successful treatment of rare neurodegenerative disease exemplifies potential of precision medicine

A 20-month-old girl suffering from a rare neurodegenerative disease was diagnosed by exome sequencing and successfully treated.

23 Oct 2015

New technique helps study protein changes in brain tissue of Alzheimer's patients

Using 10-year-old archival brain tissue from patients with Alzheimer's disease, a research team from NYU Langone Medical Center has developed a novel method to examine the structure and function of proteins at the cell level -- providing greater means to study protein changes found in Alzheimer's disease.

23 Oct 2015

Protein C News and Research

Researchers pinpoint mechanisms that cause chemoresistance in ovarian cancer patients

MGH researchers identify mechanism behind the spread of neurofibrillary tangles

Ipsen, EpiVax partner to create next generation botulinum neurotoxin and TSI therapeutics

Scientists find way to produce industrial quantities of beneficial natural compounds in tomatoes

Scalable production of gene therapy vectors: an interview with Frank Ubags

New approaches to treating lung cancer patients in New Mexico

UW researchers develop new model to more accurately predict harmful genetic mutations

Novel method for examining small molecules may provide platform for new drug design

First computational method based on evolutionary principles developed to predict protein dynamics

New DNA study may lead to better treatments for diseases caused by cellular changes

FDA approves Yondelis (trabectedin) for treatment of specific soft tissue sarcomas

Improved results yielded from new ChIP-seq protocol

MU researchers successfully treat dogs with DMD, plan for human clinical trials

Potential new drug target for acute myeloid leukemia

JDRF-funded study aims to find new types of diagnostic markers for diabetic kidney disease

Drug engineered from bananas could fight off wide range of viruses

Researchers reveal why malaria vaccine provides only moderate protection among vaccinated children

New drug delivery method could be used to target cancer, tuberculosis

Successful treatment of rare neurodegenerative disease exemplifies potential of precision medicine

New technique helps study protein changes in brain tissue of Alzheimer's patients

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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