Genetic Engineering News and Research

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Hydrogel method form synthetic scaffolds to support formation of blood vessels in engineered tissues

Next-generation hydrogels can form synthetic scaffolds to support the formation of replacement tissues and organs in the emerging area of regenerative medicine. Embedding peptides into the hydrogels stimulates the growth of essential microvascular networks to ensure a good blood supply.

12 Jul 2013

Scientists focus on the role of mutated adult neural stem cells play in human diseases

CHARGE syndrome* is a severe developmental disorder affecting multiple organs. It affects 1 in 8500 newborns worldwide. The majority of patients carry a mutation in a gene called CHD7. How this single mutation leads to the broad spectrum of characteristic CHARGE symptoms has been a mystery.

6 Jul 2013

New study could lead to better and more targeted drugs for arthritis and cancer

The increased risk of heart attack or stroke associated with many arthritis drugs may be avoidable, according to a new international study co-authored by researchers at Imperial College London.

5 Jul 2013

Nearly half a million dollars given to physicians working to cure psoriatic diseases

Twelve residents and medical students each received a one-year, $40,000 National Psoriasis Foundation fellowship to study psoriasis and psoriatic arthritis.

3 Jul 2013

Activation of brown fat increases heart-related mortality during winter

More people die from heart-disease during the winter months, and according to a new study published in the journal Cell Metabolism, the increase in mortality is possibly due to the accelerated growth of atherosclerotic plaque in the blood vessels caused by the activation of brown fat by the cold.

3 Jul 2013

FDA-approved formoterol drug improves cognitive function in mouse model of Down syndrome

An existing FDA-approved drug improves cognitive function in a mouse model of Down syndrome, according to a new study by researchers at the Stanford University School of Medicine.

3 Jul 2013

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

It's a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.

2 Jul 2013

Protein in liver plays a crucial role in mice's pregnancy and human menstrual cycle

A protein first shown to function in the liver plays a crucial role in pregnancy in mice and has a key role in the human menstrual cycle, according to researchers at the University of Montreal. Mice that were genetically engineered not to produce the liver receptor homolog-1 (Lrh-1) molecule were unable to create the uterine conditions necessary for establishing and sustaining pregnancy, resulting in the formation of defective placentas.

1 Jul 2013

Mary Ann Liebert announces launch of 3D Printing and Additive Manufacturing journal

Mary Ann Liebert, Inc., publishers announces the launch of 3D Printing and Additive Manufacturing, a highly innovative, peer-reviewed journal on this rapidly growing disruptive technology.

29 Jun 2013

Genetic elements from plants entering into eater's bloodstream turn out to be 'false positive'

In 2011 and 2012, research from China's Nanjing University made international headlines with reports that after mice ate, bits of genetic material from the plants they'd ingested could make it into their bloodstreams intact and turn the animals' own genes off.

27 Jun 2013

Study shows absence of gene leads to early onset of more serious disease in MS animal model

Scientists led by a UCSF neurology researcher are reporting that they have identified the likely genetic mechanism that causes some patients with multiple sclerosis (MS) to quickly progress to a debilitating stage of the disease while other patients progress much more slowly.

25 Jun 2013

Duke Medicine researchers identify molecular target to prevent onset of epilepsy

Duke Medicine researchers have identified a receptor in the nervous system that may be key to preventing epilepsy following a prolonged period of seizures.

21 Jun 2013

MIT study shows that SIRT1 gene plays key role in controlling circadian rhythms

Human sleeping and waking patterns are largely governed by an internal circadian clock that corresponds closely with the 24-hour cycle of light and darkness. This circadian clock also controls other body functions, such as metabolism and temperature regulation.

21 Jun 2013

Targeting particular signaling pathway can help prevent temporal lobe epilepsy, scientists report

Temporal lobe epilepsy, the most common form of epilepsy, is characterized by recurrent seizures throughout life and often behavioral abnormalities, with devastating impacts on patients and their families. Unfortunately, the condition is often not responsive to anticonvulsants. Now scientists report online June 20 in the Cell Press journal Neuron that targeting a particular signaling pathway in mice can prevent the development of temporal lobe epilepsy with just two weeks of treatment, offering hope that researchers will be able to develop effective drugs to mitigate recurrent seizures and the development of epilepsy.

21 Jun 2013

Drug increases amount of energy burned by fat tissue and promotes weight loss

A drug that mimics the activity of thyroid hormone significantly increases the amount of energy burned by fat tissue and promotes weight loss, an animal study of metabolism finds. The results were presented Sunday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

Scientists develop new tool for analyzing and characterizing aspects of the brain's neural circuitry

Scientists at the University of Massachusetts Medical School have developed a novel transgenic system which allows them to remotely activate individual brain cells in the model organism Drosophila using ambient temperature.

17 Jun 2013

Scientists genetically engineer E. coli bacteria addicted to caffeine

The latest episode in the American Chemical Society's award-winning Global Challenges/Chemistry Solutions podcast series describes bacteria that are "addicted" to caffeine in a way that promises practical uses ranging from decontamination of wastewater to bioproduction of medications for asthma.

14 Jun 2013

TAU researcher develops peptide to protect and restore microtubule function

A structure called "the microtubule network" is a crucial part of our nervous system. It acts as a transportation system within nerve cells, carrying essential proteins and enabling cell-to-cell communications. But in neurodegenerative diseases like Alzheimer's, ALS, and Parkinson's, this network breaks down, hindering motor abilities and cognitive function.

14 Jun 2013

HEXIM1 gene makes heart healthier, suppresses breast cancer metastasis

Researchers at Case Western Reserve University have found that a single gene poses a double threat to disease: Not only does it inhibit the growth and spread of breast tumors, but it also makes hearts healthier.

14 Jun 2013

Researchers identify biochemical pathway that links nail growth to fingertip regeneration

Mammals possess the remarkable ability to regenerate a lost fingertip, including the nail, nerves and even bone. In humans, an amputated fingertip can sprout back in as little as two months, a phenomenon that has remained poorly understood until now. In a paper published today in the journal Nature, researchers at NYU Langone Medical Center shed light on this rare regenerative power in mammals, using genetically engineered mice to document for the first time the biochemical chain of events that unfolds in the wake of a fingertip amputation.

13 Jun 2013

Genetic Engineering News and Research

Hydrogel method form synthetic scaffolds to support formation of blood vessels in engineered tissues

Scientists focus on the role of mutated adult neural stem cells play in human diseases

New study could lead to better and more targeted drugs for arthritis and cancer

Nearly half a million dollars given to physicians working to cure psoriatic diseases

Activation of brown fat increases heart-related mortality during winter

FDA-approved formoterol drug improves cognitive function in mouse model of Down syndrome

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

Protein in liver plays a crucial role in mice's pregnancy and human menstrual cycle

Mary Ann Liebert announces launch of 3D Printing and Additive Manufacturing journal

Genetic elements from plants entering into eater's bloodstream turn out to be 'false positive'

Study shows absence of gene leads to early onset of more serious disease in MS animal model

Duke Medicine researchers identify molecular target to prevent onset of epilepsy

MIT study shows that SIRT1 gene plays key role in controlling circadian rhythms

Targeting particular signaling pathway can help prevent temporal lobe epilepsy, scientists report

Drug increases amount of energy burned by fat tissue and promotes weight loss

Scientists develop new tool for analyzing and characterizing aspects of the brain's neural circuitry

Scientists genetically engineer E. coli bacteria addicted to caffeine

TAU researcher develops peptide to protect and restore microtubule function

HEXIM1 gene makes heart healthier, suppresses breast cancer metastasis

Researchers identify biochemical pathway that links nail growth to fingertip regeneration

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