Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Researcher receives grant to find compounds that interrupt binding of cancer cells to blood vessels

In scary movies, the killer often comes back to life mysteriously, attacking again when the main character least expects it. Blood cancers are like this too, finding a safe spot to hide during treatment and then striking again when a patient is in remission.

7 Feb 2014

Surgeons develop 'monoblock' flaps to reconstruct severe facial defects

Patients with massive burns causing complete loss of the facial skin pose a difficult challenge for reconstructive surgeons. Now a group of surgeons in China have developed an innovative technique for creating a one-piece skin flap large enough to perform full-face resurfacing, reports The Journal of Craniofacial Surgery, published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

6 Feb 2014

Chemical "signature" in blood may predict which AML patients would benefit from chemotherapy

Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found a chemical "signature" in blood-forming stem cells that predicts whether patients with acute myeloid leukemia (AML) will respond to chemotherapy.

4 Feb 2014

FDA grants Breakthrough Therapy designation to GSK's Promacta/Revolade for treatment of cytopenias

Ligand Pharmaceuticals Incorporated today announced that the U.S. Food and Drug Administration has granted its partner GlaxoSmithKline plc Breakthrough Therapy designation for Promacta/Revolade (eltrombopag) for the treatment of cytopenias in patients with severe aplastic anemia (SAA) who have had insufficient response to immunosuppressive therapy.

3 Feb 2014

New study reveals way to combat drug-resistant tumors

Cancer drugs that recruit antibodies from the body's own immune system to help kill tumors have shown much promise in treating several types of cancer. However, after initial success, the tumors often return.

31 Jan 2014

Study describes new tack in treatment of lung adenocarcinomas

The most common genetic subtype of lung cancer, which has long defied treatment with targeted therapies, has had its growth halted by a combination of two already-in-use drugs in laboratory and animal studies, setting the stage for clinical trials of the drugs in patients, researchers at Dana-Farber Cancer Institute and other scientists report in a new study.

31 Jan 2014

CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

Cell Therapeutics, Inc. today announced the initiation of an international cooperative group Phase 2 clinical trial of pacritinib in adult patients with relapsed acute myeloid leukemia (AML) with mutations of the FLT3 gene. Mutation of the FLT3 gene is found in approximately one-third of AML patients and is an independent risk factor for poor prognosis.

30 Jan 2014

Allogeneic transplants via Blood/Marrow Transplant Program show better outcomes

For the fourth consecutive year, outcomes for patients receiving allogeneic transplants through the Blood and Marrow Transplant Program at Roswell Park Cancer Institute (RPCI) have been shown to be significantly better than would be expected among the patient population treated.

29 Jan 2014

Organ and tissue donation saves lives

OneLegacy, the non-profit, federally designated organ, eye and tissue recovery agency serving the seven-country greater Los Angeles area, today issued the following statement: "Kim Pham, the 23-year-old woman who died from her injuries after being assaulted outside a Santa Ana nightclub on Jan. 18, saved five lives through the donation of her heart, kidneys, lungs, pancreas and liver to patients on the national organ transplant waiting list.

27 Jan 2014

Salmonella infections can reduce incidence of asthma, say researchers

Researchers from Germany have identified the mechanism by which Salmonella infections can reduce the incidence of asthma in mice. The research, which appears ahead of print in the journal Infection and Immunity, opens up new avenues of research that could lead to treatments.

24 Jan 2014

Use of twice-daily pill could turn deadly blood cancer into highly treatable disease

Use of a twice-daily pill could turn a deadly blood cancer into a highly treatable disease, according to scientists at Weill Cornell Medical College who led a multinational research team.

24 Jan 2014

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice. The stem cells, derived from human umbilical cord-blood and coaxed into an embryonic-like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.

24 Jan 2014

BioLineRx's BL-8040 gets FDA Orphan Drug Designation for stem cell mobilization treatment

BioLineRx, a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promising therapeutic candidates, announced today that it has received notice from the U.S. Food & Drug Administration confirming an Orphan Drug Designation of BL-8040 as a treatment for stem cell mobilization, in addition to the Orphan Drug Designation previously granted to BL-8040 as a treatment for Acute Myeloid Leukemia.

23 Jan 2014

Researchers find that 20% of women with ovarian cancer had inherited mutations in gene pathway

A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis.

23 Jan 2014

Mutation in bone cells may cause acute myeloid leukemia: Study

Acute myeloid leukemia is a blood cancer, but for many patients the cancer may originate from an unusual source: a mutation in their bone cells.

21 Jan 2014

Illumina inks multi-year supply agreement with LabCorp

Illumina, Inc. today announced it has entered into a multi-year supply agreement with Laboratory Corporation of America Holdings. The agreement gives LabCorp expanded rights to use Illumina next-generation sequencing and microarray equipment and supplies to develop, validate and introduce laboratory-developed tests to clinicians in the United States and Canada.

From Illumina, Inc. 21 Jan 2014

TSRI scientists use new technique to discover two antibodies that protect human cells from cold virus

Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new drug discovery technique, which allows them to find-relatively quickly and cheaply-antibodies that have a desired effect on cells. The TSRI scientists used the technique to discover two antibodies that protect human cells from a cold virus.

20 Jan 2014

Immune system plays important role in heart's response to injury

The immune system plays an important role in the heart's response to injury. But until recently, confusing data made it difficult to distinguish the immune factors that encourage the heart to heal following a heart attack, for example, from those that lead to further damage.

16 Jan 2014

Argon gets FDA clearance to market OptionELITE IVC filter over-the-wire delivery technique

Argon Medical Devices, Inc. announced today that the company has received clearance from the US Food and Drug Administration to begin marketing the OptionELITE retrievable inferior vena cava filter with a new over-the-wire delivery technique.

16 Jan 2014

Research reveals new therapy for preventing production of sphingolipids by lymphoma cells

Christopher Parsons, MD, Director of the HIV Malignancies Program at LSU Health Sciences Center New Orleans, is the senior author of a paper that is the first to report that specialized fat (lipid) molecules, called sphingolipids, play a key role in the survival of aggressive lymphomas caused by viruses.

15 Jan 2014

Bone Marrow News and Research

Further Reading

Researcher receives grant to find compounds that interrupt binding of cancer cells to blood vessels

Surgeons develop 'monoblock' flaps to reconstruct severe facial defects

Chemical "signature" in blood may predict which AML patients would benefit from chemotherapy

FDA grants Breakthrough Therapy designation to GSK's Promacta/Revolade for treatment of cytopenias

New study reveals way to combat drug-resistant tumors

Study describes new tack in treatment of lung adenocarcinomas

CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

Allogeneic transplants via Blood/Marrow Transplant Program show better outcomes

Organ and tissue donation saves lives

Salmonella infections can reduce incidence of asthma, say researchers

Use of twice-daily pill could turn deadly blood cancer into highly treatable disease

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

BioLineRx's BL-8040 gets FDA Orphan Drug Designation for stem cell mobilization treatment

Researchers find that 20% of women with ovarian cancer had inherited mutations in gene pathway

Mutation in bone cells may cause acute myeloid leukemia: Study

Illumina inks multi-year supply agreement with LabCorp

TSRI scientists use new technique to discover two antibodies that protect human cells from cold virus

Immune system plays important role in heart's response to injury

Argon gets FDA clearance to market OptionELITE IVC filter over-the-wire delivery technique

Research reveals new therapy for preventing production of sphingolipids by lymphoma cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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