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Oral drug used to treat blood clots in cancer patients appears to be safe and effective

Mayo Clinic researchers have found that an oral drug, apixaban, used to treat blood clots in patients undergoing cancer therapy, is safe and effective.

4 Dec 2018

Scientists use genetically engineered immune cells to fight Hodgkin and non-Hodgkin lymphoma cells

University of North Carolina Lineberger Comprehensive Cancer Center researchers reported promising early results from a clinical study of an investigational cellular immunotherapy that used a patient's own, genetically engineered immune cells to recognize and fight Hodgkin and non-Hodgkin lymphoma cells.

4 Dec 2018

Personalized scans showing the extent of atherosclerosis help decrease cardiovascular risk

A new randomized trial of over 3000 people in The Lancet finds that sharing pictorial representations of personalized scans showing the extent of atherosclerosis (vascular age and plaque in the arteries) to patients and their doctors results in a decreased risk of cardiovascular disease one year later, compared to people receiving usual information about their risk.

4 Dec 2018

Girls who gain weight rapidly at childhood are more likely to be obese at age 24

Girls who gain weight more rapidly between the ages of 5 and 15 are more likely to be obese at age 24, according to researchers.

4 Dec 2018

New strategies may improve performance of CAR-T cell therapy in treating cancer

Mayo Clinic researchers have developed two new strategies that may improve the performance of chimeric antigen receptor therapy in treating cancer. They are presenting results of their preclinical research at the 2018 annual meeting of the American Society of Hematology in San Diego.

3 Dec 2018

New gene therapy treatment for Sickle Cell Anemia reverses symptoms in adults

After over a decade of preclinical research and development, a new gene therapy treatment for Sickle Cell Anemia is reversing disease symptoms in two adults and showing early potential for transportability to resource-challenged parts of the world where SCA is most common.

3 Dec 2018

Study examines whether taking multiple medications for heart failure can limit abilities in older adults

As we age, we tend to develop a number of chronic health conditions and concerns. Often, managing health problems can mean that older adults may take many different medications. When older adults take five or more medicines (a scenario health experts call "polypharmacy", it can increase the risk of harmful side effects.

3 Dec 2018

Latest advances in AI for aging and longevity research

Insilico Medicine, one of the leaders in artificial intelligence for drug discovery, biomarker development, digital medicine, and aging research announced today the publication of its recent paper titled "Artificial Intelligence for Aging and Longevity Research: Recent Advances and Perspectives" in Ageing Research Reviews, one of the highest-impact journals in the field.

3 Dec 2018

Alcohol consumption may attenuate long-term weight loss in people with Type 2 diabetes

Research shows that losing weight can help prevent or delay the onset of diabetes. While best practice for weight loss often includes decreasing or eliminating calories from alcohol, few studies examine whether people who undergo weight loss treatment report changes in alcohol intake and whether alcohol influences their weight loss.

3 Dec 2018

Study shows outcomes of CAR T-cell therapy when used as standard of care for lymphoma

Chimeric antigen receptor T-cell therapy, or CAR T, was named the 2017 Advance of the Year by the American Society of Clinical Oncology. The FDA approved two CAR T products last year for treatment of adult large B-cell lymphoma based on the exceptional patient outcomes seen in clinical trials.

3 Dec 2018

UK scientists find new way to identify patients with aggressive lymphoma

UK scientists have found a new way to identify people with the most aggressive types of lymphoma who are less likely to respond to standard drugs.

3 Dec 2018

Genetic relic of the 'Black Death' may provide clues for treating fatal liver scarring

A gene mutation that is believed to have safeguarded some people in 14th century Europe from the bubonic plague today may be protecting HIV patients co-infected with hepatitis C from potentially fatal liver scarring, says a University of Cincinnati College of Medicine physician-scientist.

3 Dec 2018

Using nanocarrier-delivered microRNA to target sepsis

One in three patients who die in the U.S. dies of sepsis, according to the Centers for Disease Control and Prevention. It is one of the leading causes of death in intensive care units and, with an estimated price tag of $20 billion in 2011, the most expensive condition that hospitals treat.

3 Dec 2018

Mediterranean diet in pregnancy linked to lower risk of having children with accelerated growth

The Mediterranean diet is characterised by a high content of fruits, vegetables, olive oil, legumes and nuts. This healthy diet pattern has been associated with lower obesity and cardiometabolic risk in adults, but few studies have focused on children.

3 Dec 2018

Research highlights ability of Bio-Rad's ddPCR in quantifying minimal residual disease

More than 30 abstracts presented at the 60th American Society of Hematology Annual Meeting & Exposition in San Diego, December 1-4, featured research highlighting the ability of Bio-Rad's Droplet Digital PCR to provide high sensitivity and accuracy in quantifying minimal residual disease -- those remaining cancer cells after therapy that are associated with relapse -- in blood diseases such as leukemia.

3 Dec 2018

Study provides new insights into how prions enter the brain

The spread of prions to the brain does not occur by direct transmission across the blood-brain barrier, according to a study published November 29 in the open-access journal PLOS Pathogens by Annika Keller and Adriano Aguzzi of the University Hospital Zürich, and colleagues.

3 Dec 2018

Study: 51% of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma

A follow-up analysis of patients enrolled in a Phase I/II multi-center trial for diffuse large B-cell lymphoma reported 51 percent of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years post-treatment.

3 Dec 2018

Cleveland Clinic expert develops personalized prediction model for Myelodysplastic Syndromes

At the American Society of Hematology Annual Meeting, Cleveland Clinic medical hematologist and oncologist Aziz Nazha, M.D., will present results of a personalized prediction model that surpassed current prediction models for Myelodysplastic Syndromes.

3 Dec 2018

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

3 Dec 2018

Daily hydroxyurea treatment may bring some relief for African children with sickle cell anemia

A daily hydroxyurea pill may finally bring some relief for young children living with the painful and deadly blood disease sickle cell anemia in resource-challenged sub-Saharan Africa, where the disease is prevalent and health care availability is suboptimal.

3 Dec 2018

Blood News and Research

Oral drug used to treat blood clots in cancer patients appears to be safe and effective

Scientists use genetically engineered immune cells to fight Hodgkin and non-Hodgkin lymphoma cells

Personalized scans showing the extent of atherosclerosis help decrease cardiovascular risk

Girls who gain weight rapidly at childhood are more likely to be obese at age 24

New strategies may improve performance of CAR-T cell therapy in treating cancer

New gene therapy treatment for Sickle Cell Anemia reverses symptoms in adults

Study examines whether taking multiple medications for heart failure can limit abilities in older adults

Latest advances in AI for aging and longevity research

Alcohol consumption may attenuate long-term weight loss in people with Type 2 diabetes

Study shows outcomes of CAR T-cell therapy when used as standard of care for lymphoma

UK scientists find new way to identify patients with aggressive lymphoma

Genetic relic of the 'Black Death' may provide clues for treating fatal liver scarring

Using nanocarrier-delivered microRNA to target sepsis

Mediterranean diet in pregnancy linked to lower risk of having children with accelerated growth

Research highlights ability of Bio-Rad's ddPCR in quantifying minimal residual disease

Study provides new insights into how prions enter the brain

Study: 51% of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma

Cleveland Clinic expert develops personalized prediction model for Myelodysplastic Syndromes

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

Daily hydroxyurea treatment may bring some relief for African children with sickle cell anemia

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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