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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Pregnant rats fed with high-fat diet experience preeclampsia-like syndromes

Preeclampsia is a relatively common pregnancy disorder, characterized by primary hypertension and proteinuria. In patients with severe preeclampsia, eclampsia can develop, causing nervous system symptoms and signs.

9 Aug 2013

Study: 3 enzymes required for building sugar superstructure involved in muscular dystrophies

For many inherited diseases, such as cystic fibrosis or Huntington disease, the disease-causing genetic mutation damages or removes a protein that has an essential role in the body. This protein defect is the root cause of the disease symptoms.

9 Aug 2013

New reagent kits for intracellular staining from Beckman Coulter Life Sciences

PerFix-Expose1 and PerFix-nc1, innovative new reagent kits for intracellular staining from Beckman Coulter Life Sciences, minimize sample manipulation for a streamlined workflow that delivers high quality results. Developed for use on Beckman Coulter’s Gallios1 and Navios2 series flow cytometers and compatible with all Beckman Coulter Life Sciences’ fluorochromes, the kits enable a clear focus on the cytoplasmic and nuclear compartments of the cell.

8 Aug 2013

High mobility group (HMG) genes and cancer: an interview with Dr. Linda Resar, Johns Hopkins University School of Medicine

High mobility group A genes are highly expressed in all aggressive cancers studied to date. These genes encode the high mobility group A (HMGA) proteins. In other words, these genes provide the genetic “code” necessary to produce HMGA proteins.

8 Aug 2013

Findings could lead to development of therapeutic agents for age-related diseases

Scientists at Sanford-Burnham Medical Research Institute have identified a key factor that regulates the autophagy process, a kind of cleansing mechanism for cells in which waste material and cellular debris is gobbled up to protect cells from damage, and in turn, modulates aging.

8 Aug 2013

Penn State researchers find that protein changes can control gene functions

A Penn State-led research team has found that changes to proteins called histones, which are associated with DNA, can control whether or not a gene is allowed to function. The changes may be important in maintaining the genes' "expression potential" so that future cells behave as their parent cells did.

8 Aug 2013

Ret enzyme may be a novel therapeutic target in selected groups of breast cancer patients

Scientists at the MedUni Vienna, in collaboration with a working group led by Nancy Hynes at the University of Basel, have discovered a new approach in the treatment of breast cancer: an international team involving the Clinical Institute of Pathology at the MedUni Vienna has been able to demonstrate the activation of a receptor, the Ret protein (Rearranged during transfection), on the surface of breast cancer cells. Increased levels of this protein are associated with a lower likelihood of survival for breast cancer patients.

8 Aug 2013

Understanding the movement of neurons sheds light on how cancer cells invade health tissues

The invasion of brain-tumor cells into surrounding tissue requires the same protein molecule that neurons need to migrate into position as they differentiate and mature, according to new research from the University of Illinois at Chicago College of Medicine and published August 7 in the online journal PLOS ONE.

8 Aug 2013

Janssen receives EC approval to use VELCADE as induction therapy in patients with multiple myeloma

Janssen-Cilag International NV announced today that the European Commission has approved the use of VELCADE (bortezomib) as induction therapy (a first therapeutic option) in combination with dexamethasone or thalidomide and dexamethasone. This licence extension will apply to adult patients with previously-untreated multiple myeloma who are eligible for high-dose chemotherapy with haematological stem cell transplantation.

8 Aug 2013

Cognitive decline with age is natural part of life, OSU researchers find

If you forget where you put your car keys and you can't seem to remember things as well as you used to, the problem may well be with the GluN2B subunits in your NMDA receptors.

8 Aug 2013

ASU expert receives $1.6 million grant to advance microscopy imaging research

At Arizona State University's Biodesign Institute, Nongjian (NJ) Tao has been designing advanced microscopy methods with the ambitious aim of capturing molecular-scale phenomena in living systems. The new techniques, which combine multiple imaging modalities, are poised to revolutionize the study of biology and the development of new drugs.

8 Aug 2013

Research findings may give scientists a way to destroy cancerous cells

Researchers at Warwick Medical School have identified the key role played by a team of proteins in the process of mitosis. Working out how to control them may give scientists a way to destroy cancerous cells.

8 Aug 2013

Eteplirsen offers great hope to patients with Duchenne muscular dystrophy

Results from a clinical trial of eteplirsen, a drug designed to treat Duchenne muscular dystrophy, suggest that the therapy allows participants to walk farther than people treated with placebo and dramatically increases production of a protein vital to muscle growth and health.

8 Aug 2013

NCI renews UCLA prostate SPORE grant

UCLA's Jonsson Comprehensive Cancer Center and the department of urology at the David Geffen School of Medicine at UCLA have been notified that their standing as a National Cancer Institute Specialized Program of Research Excellence site in prostate cancer has been renewed for another five years.

8 Aug 2013

Moderate exercise could help guard against and treat tendon disease

Moderate exercise could be good for keeping your tendons healthy according to new research from the University of East Anglia funded by Arthritis Research UK.

8 Aug 2013

Researchers identify mechanism responsible for loss of tumor-suppressor gene in soft-tissue sarcomas

Researchers have discovered a novel mechanism responsible for the loss of a critical tumor-suppressor gene in rhabdomyosarcoma and other soft-tissue sarcomas, rare cancers that strike mainly children and often respond poorly to treatment. Their cause is largely unknown.

8 Aug 2013

TSRI scientists decode important molecular signal that guides development of neocortex

Scientists at The Scripps Research Institute have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex. The largest and most recently evolved region of the brain, the neocortex is particularly well developed in humans and is responsible for sensory processing, long-term memory, reasoning, complex muscle actions, consciousness and other functions.

8 Aug 2013

High-tech laser technique offers control of gene therapy and genetic engineering method

The applications of gene therapy and genetic engineering are broad: everything from pet fish that glow red to increased crop yields worldwide to cures for many of the diseases that plague humankind.

8 Aug 2013

Brain tumor cells in arrested development contribute to cell variety that protects cancer

A program that pushes immature cells to grow up and fulfill their destiny as useful, dedicated cells is short-circuited in the most common and deadly form of brain tumor, scientists at The University of Texas MD Anderson Cancer Center report this week in the Early Edition of the Proceedings of the National Academy of Sciences.

8 Aug 2013

Scientists identify important molecular signal that guides development of brain

Scientists at The Scripps Research Institute (TSRI) have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex.

8 Aug 2013

Protein News and Research

Further Reading

Pregnant rats fed with high-fat diet experience preeclampsia-like syndromes

Study: 3 enzymes required for building sugar superstructure involved in muscular dystrophies

New reagent kits for intracellular staining from Beckman Coulter Life Sciences

High mobility group (HMG) genes and cancer: an interview with Dr. Linda Resar, Johns Hopkins University School of Medicine

Findings could lead to development of therapeutic agents for age-related diseases

Penn State researchers find that protein changes can control gene functions

Ret enzyme may be a novel therapeutic target in selected groups of breast cancer patients

Understanding the movement of neurons sheds light on how cancer cells invade health tissues

Janssen receives EC approval to use VELCADE as induction therapy in patients with multiple myeloma

Cognitive decline with age is natural part of life, OSU researchers find

ASU expert receives $1.6 million grant to advance microscopy imaging research

Research findings may give scientists a way to destroy cancerous cells

Eteplirsen offers great hope to patients with Duchenne muscular dystrophy

NCI renews UCLA prostate SPORE grant

Moderate exercise could help guard against and treat tendon disease

Researchers identify mechanism responsible for loss of tumor-suppressor gene in soft-tissue sarcomas

TSRI scientists decode important molecular signal that guides development of neocortex

High-tech laser technique offers control of gene therapy and genetic engineering method

Brain tumor cells in arrested development contribute to cell variety that protects cancer

Scientists identify important molecular signal that guides development of brain

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