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ACR releases two new provisional definitions of rheumatoid arthritis remission

The American College of Rheumatology today announced the release of two new provisional definitions of rheumatoid arthritis remission, which are to be applied to future RA clinical trials.

4 Feb 2011

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

In a discovery that may lead to a new treatment for breast cancer that has spread to the bone, a Princeton University research team has unraveled a mystery about how these tumors take root.

4 Feb 2011

Miracle boy born after new infertility therapy

A Lancashire couple Andrew and Louise Riley have been blessed with a “miracle baby boy” thanks to a pioneering new genetic screening process. Elliott Riley was born just after Christmas after the Rileys opted for a relatively new technique called array comparative genomic hybridisation (CGH) after 10 years of infertility treatments. Mrs. Riley, 37, and her husband, 39, said they were delighted to welcome Elliott on December 30.

3 Feb 2011

Neurons activated by learning show extensive expansion of structure

When a laboratory rat learns how to reach for and grab a food pellet - a pretty complex and unnatural act for a rodent - the acquired knowledge significantly alters the structure of the specific brain cells involved, which sprout a whopping 22 percent more dendritic spines connecting them to other motor neurons.

3 Feb 2011

Blood clotting protein could be used as 'biomarker' for mucopolysaccharide diseases

University of Manchester scientists have shown that a protein involved in blood clotting can be used to diagnose and subsequently monitor the treatment of a group of childhood genetic diseases.

3 Feb 2011

First therapeutic vaccine designed from dendritic cells of patient achieves significant response

The therapeutic vaccines are a priority research line of the HIVACAT, the catalan programme for the development of therapeutic vaccines and prevention against the Human Immunodeficiency Virus (HIV). This type of therapeutic vaccine helps the patients who are carriers of the virus, combat infection and control the appearance of AIDS in the same way as with the current antiretroviral treatments.

3 Feb 2011

Researchers develop hard X-ray laser to determine structure of biomolecules

Unraveling the molecular basis of life is an age-old quest of humanity. A breakthrough towards this goal was reported in a pair of studies published Feb. 3 in the scientific journal Nature, detailing a new method developed to determine structures of biomolecules based on diffraction from protein nanocrystals that are so small that they are not even visible under the microscope.

3 Feb 2011

Losartan improves effectiveness of nanotherapeutics against cancer

Low doses of an inexpensive, FDA-approved hypertension medication may improve the results of nanotherapeutic approaches to cancer treatment. In a report in the early edition of Proceedings of the National Academy of Sciences, Massachusetts General Hospital (MGH) investigators describe experiments showing that the generic drug losartan, by modifying the network of collagen fibers that characterizes most solid tumors, improved the effectiveness of two nanotherapeutics against several types of cancer.

3 Feb 2011

Concert and WRAIR enter CRADA to evaluate novel compound for seizure protection associated with TBI

Concert Pharmaceuticals, Inc. today announced that it has entered into a Cooperative Research and Development Agreement with the Walter Reed Army Institute of Research. The CRADA will allow the WRAIR to conduct preclinical testing on a novel compound derived from Concert's DCE Platform™ (deuterated chemical entity platform) for seizure protection associated with traumatic brain injury, a major public health concern.

3 Feb 2011

Researchers to develop new diagnostics platform for early detection of lung cancer

The earlier cancers can be detected, the better the chances of a cure. Researchers are now working to develop a new diagnostics platform with which the illness can be diagnosed in its early stages, even during a visit to the general practitioner: protein biomarkers in exhaled air divulge the presence of pathological cells in the lung.

3 Feb 2011

HealthCore, AstraZeneca collaborate to conduct real-world studies on disease states, treatment

AstraZeneca Pharmaceuticals LP and HealthCore, the health outcomes research subsidiary of WellPoint, today announced a collaborative agreement to conduct real-world studies designed to determine how to most effectively and economically treat disease.

3 Feb 2011

Generation of iPSCs can be enhanced by modulating miRNA action

Stem cells are ideal tools to understand disease and develop new treatments; however, they can be difficult to obtain in necessary quantities. In particular, generating induced pluripotent stem (iPS) cells can be an arduous task because reprogramming differentiated adult skin cells into iPS cells requires many steps and the efficiency is very low - researchers might end up with only a few iPS cells even if they started with a million skin cells.

3 Feb 2011

Largazole appears to be an ideal blueprint for developing new drugs against bone diseases

One of Mother Nature's latest gifts to medical science is stirring excitement with the discovery that the substance - obtained from a coral-reef inhabiting cyanobacterium - appears to be an ideal blueprint for developing new drugs for serious fractures, osteoporosis, and other bone diseases.

3 Feb 2011

Damaged heart rebuilt with heart stem cells from children with congenital heart disease

A new study, revealing that heart stem cells from children with congenital heart disease were able to rebuild the damaged heart in the laboratory, could provide a new outlet for Emerging Healthcare Solutions' NASA bioreactor.

2 Feb 2011

Study suggests human amniotic cells 'cross talk' with melatonin receptor MT1

Human amniotic epithelial cells, stem cells derived from human placenta left over from live births and generally discarded, proliferated and differentiated when they interacted with one kind of melatonin receptor, MT1. This potentially therapeutic response occurred when the stem cells were transplanted into laboratory test tube and animal models of stroke. The same cells did not perform similarly when interacting with melatonin receptor MT2.

2 Feb 2011

Thermo Fisher Scientific 2010 revenues increase 7% to $10.79 billion

Thermo Fisher Scientific Inc., the world leader in serving science, today reported its financial results for the fourth quarter and full year ended December 31, 2010.

From Thermo Fisher Scientific Inc. 2 Feb 2011

Nitrate boosts efficiency of mitochondria

The spinach-eating cartoon character Popeye has much to teach us, new research from the Swedish medical university Karolinska Institutet shows. The muscles' cellular power plants - the mitochondria - are boosted by nitrate, a substance found in abundance in vegetables such as lettuce, spinach and beetroot.

2 Feb 2011

First blood-based diagnostic test for LAM

Circadian Technologies has announced today that in conjunction with Cincinnati Children's Hospital Medical Center it has begun offering its LAM diagnostic, which is offered as a laboratory test compliant with CAP (College of American Pathologists) /CLIA regulations.

2 Feb 2011

Zebrafish research findings may provide potential to improve kidney function in humans

It is estimated that up to 10 percent of the U.S. population may have some form of renal disease, with 450,000 patients with end stage renal disease requiring hemodialysis. Researchers at Brigham and Women's Hospital, Massachusetts General Hospital and the University of Pittsburgh have identified a cell in zebrafish that can be transplanted from one fish to another to regenerate nephrons, providing the potential to improve kidney function.

2 Feb 2011

Trained dog sniffs out colon cancer with 98% accuracy

For the study the researchers at Kyushu University trained an 8-year-old female Labrador retriever named Marine who was given breath and stool samples of 306 patients, collected right before they received colonoscopies.

2 Feb 2011

Laboratory News and Research

ACR releases two new provisional definitions of rheumatoid arthritis remission

Scientists unravel mystery about how new tumors in individuals with breast cancer take root

Miracle boy born after new infertility therapy

Neurons activated by learning show extensive expansion of structure

Blood clotting protein could be used as 'biomarker' for mucopolysaccharide diseases

First therapeutic vaccine designed from dendritic cells of patient achieves significant response

Researchers develop hard X-ray laser to determine structure of biomolecules

Losartan improves effectiveness of nanotherapeutics against cancer

Concert and WRAIR enter CRADA to evaluate novel compound for seizure protection associated with TBI

Researchers to develop new diagnostics platform for early detection of lung cancer

HealthCore, AstraZeneca collaborate to conduct real-world studies on disease states, treatment

Generation of iPSCs can be enhanced by modulating miRNA action

Largazole appears to be an ideal blueprint for developing new drugs against bone diseases

Damaged heart rebuilt with heart stem cells from children with congenital heart disease

Study suggests human amniotic cells 'cross talk' with melatonin receptor MT1

Thermo Fisher Scientific 2010 revenues increase 7% to $10.79 billion

Nitrate boosts efficiency of mitochondria

First blood-based diagnostic test for LAM

Zebrafish research findings may provide potential to improve kidney function in humans

Trained dog sniffs out colon cancer with 98% accuracy

A guide to density measurement excellence eBook

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