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Targeted nanomedicines could help prevent heart attacks caused by atherosclerosis

Nanometer-sized "drones" that deliver a special type of healing molecule to fat deposits in arteries could become a new way to prevent heart attacks caused by atherosclerosis, according to a study in pre-clinical models by scientists at Brigham and Women's Hospital and Columbia University Medical Center.

19 Feb 2015

TNF signaling molecule triggers Crohn's disease, ulcerative colitis

Cells lining the intestinal tract form a critical barrier, protecting our bodies from the billions of bacteria living in the gut. Breaches in this barrier are driven largely by a single signaling molecule called tumor necrosis factor (TNF), elevated amounts of which are associated with inflammatory bowel diseases like Crohn's disease and ulcerative colitis.

17 Feb 2015

Scientists demonstrate the importance of RNA editing in melanoma development

The importance of RNA editing in melanoma has been demonstrated by scientists at The University of Texas MD Anderson Cancer Center. The study revealed that a lack of RNA editing, a process by which information inside RNA molecules is transformed, leads to tumor growth and progression through manipulation of proteins.

17 Feb 2015

Study shows amyloid formation may link type 2 diabetes and Alzheimer disease

The pathological process amyloidosis, in which misfolded proteins (amyloids) form insoluble fibril deposits, occurs in many diseases, including Alzheimer disease (AD) and type 2 diabetes mellitus (T2D).

17 Feb 2015

Research findings may point to new treatment for patients with Mitofusin 2 deficiency

Researchers have discovered a novel role for Mitofusin 2, and the findings may point to a new treatment for patients with diseases caused by loss of the mitochondrial protein.

16 Feb 2015

Researchers discover molecular 'switch' that controls replication, transcription of mitochondria DNA

A team of researchers led by Dmitry Temiakov, PhD, of the Rowan University School of Osteopathic Medicine (RowanSOM), has discovered a molecular 'switch' that controls replication and transcription of mitochondria DNA, a key finding that could influence the development of targeted therapies for cancer, developmental processes related to fertility and aging.

16 Feb 2015

Biotech experts to establish ethical guidelines in cellular biotechnology at BEINGS 2015

In May 2015 Atlanta will host Biotechnology and the Ethical Imagination: A Global Summit (BEINGS), an international summit drawing together the world's thought leaders on the highly debated issues of cellular biotechnology.

13 Feb 2015

Study shows how cannabidiol works within cells

A team of Stony Brook University researchers have identified fatty acid binding proteins (FABPs) as intracellular transporters for two ingredients in marijuana, THC and CBD (cannabidiol).

13 Feb 2015

Drug similar to Gleevec may help tame some brain cancers

The drug Gleevec (imatinib mesylate) is well known not only for its effectiveness against chronic myeloid leukemia (CML) and acute lymphoblastic leukemia, but also for the story behinds its development. The drug was specifically designed to target an abnormal molecule--a fusion of two normal cell proteins--that fueled a tumor's growth.

10 Feb 2015

Mice genetically deficient in serotonin are more vulnerable to social stressors

Mice genetically deficient in serotonin -- a crucial brain chemical implicated in clinical depression -- are more vulnerable than their normal littermates to social stressors, according to a Duke study appearing this week in the Proceedings of the National Academy of Sciences.

10 Feb 2015

Study reveals how low levels of profilin 1 protein in breast tumours invade other tissues

A new study led by José Javier Bravo-Cordero, Spanish researcher at the Albert Einstein College of Medicine in New York, details how cells with low levels of the profilin 1 protein in breast tumours increase their capacity to metastasise and invade other tissues.

9 Feb 2015

Researchers develop smartphone accessory for rapid diagnosis of infectious diseases at point of care

A team of researchers, led by Samuel K. Sia, associate professor of biomedical engineering at Columbia Engineering, has developed a low-cost smartphone accessory that can perform a point-of-care test that simultaneously detects three infectious disease markers from a finger prick of blood in just 15 minutes.

5 Feb 2015

Three Keck Medicine scientists of USC receive $4.3 million from CIRM for stem cell research

Three scientists from Keck Medicine of the University of Southern California have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine for research that includes creating a temporary liver for transplant patients, finding novel ways to treat immune disorders and blood diseases and developing a new animal model for exploring diseases like heart failure, diabetes and neurodegenerative diseases.

5 Feb 2015

Parents can pass silenced genes to offspring through a specific mechanism

For more than a century, scientists have understood the basics of inheritance: if good genes help parents survive and reproduce, the parents pass those genes along to their offspring. And yet, recent research has shown that reality is much more complex: genes can be switched off, or silenced, in response to the environment or other factors, and sometimes these changes can be passed from one generation to the next.

4 Feb 2015

New test can help measure vital aspects of retinal health

New research published in the February 2015 issue of The FASEB Journal details a test developed using mice that can help measure two important aspects of retinal health--the function of retinal blood vessels and light-detecting cells. This approach opens new possibilities for understanding the molecular changes that occur in retinal disease and for evaluating the benefits of treatment early in the course of disease.

3 Feb 2015

Study reveals how the brain can use fatty acids to control liver lipid production

Ways of keeping the heart healthy has widened, with the discovery that the brain can help fight off hardening of the arteries.

31 Jan 2015

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Researchers Irving L. Weissman and Joan Massagué have won this year's Charles Rodolphe Brupbacher Prize for Cancer Research: Weissman, from Stanford University, for his work on healthy and sick stem cells; Massagué, from Memorial Sloan Kettering Cancer Center in New York, for his research on metastatic spread.

31 Jan 2015

Researchers create customized soap bubbles that promote drug and vaccine delivery

When University of Maryland Professors Philip DeShong and Daniel Stein began tagging soap bubbles with biomolecules, they had no idea this technology would one day be poised to change the way drugs and vaccines fight against bacteria, viruses and cancer.

29 Jan 2015

Young Researcher's Meeting on Primary Ciliary Dyskinesia to be held in Bern, Switzerland

Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disorder that affects approximately 1 in 20,000 individuals.

29 Jan 2015

New study shows mechanism behind tubulin transport in cilia

Defective cilia can lead to a host of diseases and conditions in the human body--from rare, inherited bone malformations to blindness, male infertility, kidney disease and obesity. Scientists knew that somehow these tiny cell organelles become deformed and cause these diseases because of a problem related to their assembly, which requires the translocation of vast quantities of the vital cell protein tubulin.

28 Jan 2015

Cell Biology News and Research

Targeted nanomedicines could help prevent heart attacks caused by atherosclerosis

TNF signaling molecule triggers Crohn's disease, ulcerative colitis

Scientists demonstrate the importance of RNA editing in melanoma development

Study shows amyloid formation may link type 2 diabetes and Alzheimer disease

Research findings may point to new treatment for patients with Mitofusin 2 deficiency

Researchers discover molecular 'switch' that controls replication, transcription of mitochondria DNA

Biotech experts to establish ethical guidelines in cellular biotechnology at BEINGS 2015

Study shows how cannabidiol works within cells

Drug similar to Gleevec may help tame some brain cancers

Mice genetically deficient in serotonin are more vulnerable to social stressors

Study reveals how low levels of profilin 1 protein in breast tumours invade other tissues

Researchers develop smartphone accessory for rapid diagnosis of infectious diseases at point of care

Three Keck Medicine scientists of USC receive $4.3 million from CIRM for stem cell research

Parents can pass silenced genes to offspring through a specific mechanism

New test can help measure vital aspects of retinal health

Study reveals how the brain can use fatty acids to control liver lipid production

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Researchers create customized soap bubbles that promote drug and vaccine delivery

Young Researcher's Meeting on Primary Ciliary Dyskinesia to be held in Bern, Switzerland

New study shows mechanism behind tubulin transport in cilia

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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