Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

IU researchers awarded $3.2 million grant to develop new treatments for pancreatic cancer

Two Indiana University researchers have been awarded a multi-year, $3.2 million grant to develop and improve therapies for pancreatic cancer, the fourth leading cause of cancer death in the United States.

14 Mar 2013

Scientists to create new human monoclonal antibody targeting protein associated with cancer

Researchers have discovered a unique monoclonal antibody that can effectively reach inside a cancer cell, a key goal for these important anticancer agents, since most proteins that cause cancer or are associated with cancer are buried inside cancer cells.

14 Mar 2013

Iron imbalance caused by prion proteins leads to cell death in CJD, researchers find

An iron imbalance caused by prion proteins collecting in the brain is a likely cause of cell death in Creutzfeldt-Jakob disease (CJD), researchers at Case Western Reserve University School of Medicine have found.

14 Mar 2013

Research finding aids efforts toward cytomegalovirus vaccine

A virus most people probably have never heard of, but that the majority of us carry, is the No. 1 infectious cause of congenital birth defects in the U.S. today. Because of cytomegalovirus (CMV) infection during in utero development, 1 in 750 children are born with or develop permanent disabilities such as hearing loss or brain damage.

14 Mar 2013

Scientists sign licensing agreement for anticancer substances

Most cancer patients die of the disease because tumor cells spread to other sites in the body and form new tumors, so-called metastases.

14 Mar 2013

3-D structure of HNF-4α reveals new pockets that could be targeted with therapeutic drugs

Researchers at Sanford-Burnham Medical Research Institute have determined the complete three-dimensional structure of a protein called HNF-4α.

14 Mar 2013

Two faculty members find association between gum disease and obesity

Blood on your toothbrush can be a warning sign of gum disease. And, if you are overweight, it can indicate other serious health issues, such as diabetes, heart disease and high blood pressure.

13 Mar 2013

Study demonstrates relationship between protein HERC2 and human diseases

Researchers from the research group in growth factors and cell differentiation at IDIBELL and the University of Barcelonahave participated in an international study that has identified the genetic cause of developmental delay observed in Amish individuals in the USA.

13 Mar 2013

MGH investigators identify new disease that causes widespread chronic pain in children

Massachusetts General Hospital (MGH) investigators have described what may be a newly identified disease that appears to explain some cases of widespread chronic pain and other symptoms in children and young adults.

13 Mar 2013

Studies show protein semaphorin 3A helps detect acute kidney injury

A guidance cue that helps kidneys form may also be a red flag that they are in danger, researchers report.

13 Mar 2013

Eplerenone may also reduce risk of heart failure, shows REMINDER trial

The prescription drug eplerenone appears to reduce the risk of cardiovascular mortality and heart failure after a heart attack by more than one-third, according to research presented today at the American College of Cardiology's 62nd Annual Scientific Session.

13 Mar 2013

Smad7 protein protects against or heals mouth sores associated with cancer treatment

Mouse model studies show that administered genetically or topically, protein Smad7 protects against or heals mouth sores commonly associated with cancer treatment.

13 Mar 2013

ADP-ribose plays key role in repairing cellular DNA damage

Attaching chains of the small molecule ADP-ribose to proteins is important for a cell's survival and the repair of DNA damage, making this process a promising target for the development of new cancer drugs.

13 Mar 2013

Bitter melon juice restricts ability of pancreatic cancer cells to metabolize glucose

A University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose, thus cutting the cells' energy source and eventually killing them.

13 Mar 2013

Mini-chromosome maintenance protein can change DNA topology: Study

A team of USC scientists has identified a protein that can change DNA topology, making DNA twist up into a so-called "supercoil."

12 Mar 2013

Targeting Mer receptors sensitize AML and ALL to chemotherapies

Two University of Colorado Cancer Center studies show that the protein receptor Mer is overexpressed in many leukemias, and that inhibition of this Mer receptor results in the death of leukemia cells - without affecting surrounding, healthy cells.

12 Mar 2013

Cangrelor solidly outperforms clopidogrel during percutaneous coronary intervention

The experimental anti-clotting drug cangrelor solidly outperformed commonly used clopidogrel in a large global trial of patients who underwent coronary stent procedures, according to data from the phase III CHAMPION PHOENIX study presented today at the American College of Cardiology's 62nd Annual Scientific Session.

12 Mar 2013

Cangrelor more effective than clopidogrel in preventing blood clots

A new and experimental anti-clotting drug, cangrelor, proved better than the commonly used clopidogrel and was significantly more effective at preventing blood clots in a large trial of patients who underwent coronary stent procedures.

12 Mar 2013

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

Antibodies and in the case of Ablynx, Nanobodies, can be raised and selected to bind with high affinity selectively to cancer cells in a tumour. Cancer cells are exquisitely sensitive to certain toxins such as the PBDs produced by Spirogen.

12 Mar 2013

Pneumococcal vaccine pre-clinical development supported by £0.2 million award from Biomedical Catalyst

ImmBio (Immunobiology Ltd), a biopharmaceutical company developing innovative vaccines against serious infectious diseases, today announced that the UK government-backed Biomedical Catalyst has awarded the company approximately £0.2 million ($0.3 million) to support pre-clinical development of its pneumococcal vaccine, PnuBioVax™, which targets a wide range of strains of the bacteria.

12 Mar 2013

Protein News and Research

Further Reading

IU researchers awarded $3.2 million grant to develop new treatments for pancreatic cancer

Scientists to create new human monoclonal antibody targeting protein associated with cancer

Iron imbalance caused by prion proteins leads to cell death in CJD, researchers find

Research finding aids efforts toward cytomegalovirus vaccine

Scientists sign licensing agreement for anticancer substances

3-D structure of HNF-4α reveals new pockets that could be targeted with therapeutic drugs

Two faculty members find association between gum disease and obesity

Study demonstrates relationship between protein HERC2 and human diseases

MGH investigators identify new disease that causes widespread chronic pain in children

Studies show protein semaphorin 3A helps detect acute kidney injury

Eplerenone may also reduce risk of heart failure, shows REMINDER trial

Smad7 protein protects against or heals mouth sores associated with cancer treatment

ADP-ribose plays key role in repairing cellular DNA damage

Bitter melon juice restricts ability of pancreatic cancer cells to metabolize glucose

Mini-chromosome maintenance protein can change DNA topology: Study

Targeting Mer receptors sensitize AML and ALL to chemotherapies

Cangrelor solidly outperforms clopidogrel during percutaneous coronary intervention

Cangrelor more effective than clopidogrel in preventing blood clots

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

Pneumococcal vaccine pre-clinical development supported by £0.2 million award from Biomedical Catalyst

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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