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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Loss of Dickopf-1 restores neurogenesis and memory in animal model

Loss of the molecule Dickopf-1 in the hippocampus in older animals increases neurogenesis, research shows.

26 Feb 2013

Researchers improve NanoVelcro device to better grab cancer cells as blood passes by them

Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients' tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

26 Feb 2013

Recombinant Newcastle disease virus kills all kinds of prostate cancer cells

A recombinant Newcastle disease virus kills all kinds of prostate cancer cells, including hormone resistant cells, but leaves normal cells unscathed, according to a paper published online ahead of print in the Journal of Virology.

26 Feb 2013

Experts analyse biological function of Shewanella-like protein phosphatase

Experts have disabled a unique member of the signalling proteins which are essential for the development of the malaria parasite. They have produced a mutant lackingthe ancient bacterial Shewanella-like protein phosphatase known as SHLP1 (pronounced shelph). This mutant is unable to complete its complex life cycle and is arrested in its development in the mosquito.

26 Feb 2013

HDAC-mediated mechanisms play critical role in regulating lung repair and regeneration

Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health.

26 Feb 2013

High life inadvisable after Fontan procedure

Living at even a moderate altitude may have an adverse impact on the health and survival of patients who have undergone the Fontan procedure for single-ventricle anatomy, say researchers.

25 Feb 2013

Ampio to initiate dose escalation run-in study for treatment of knee osteoarthritis

Ampio Pharmaceuticals, Inc. announced today that it's Phase III clinical study of Ampion™ for the treatment for osteoarthritis of the knee will include a dose-escalation run-in study as recommended by the FDA.

25 Feb 2013

Researchers map complex interactions of proteins that control inflammation

Inflammatory response plays a major role in both health protection and disease generation. While the symptoms of disease-related inflammatory response have been know, scientists have not understood the mechanisms that underlie it.

25 Feb 2013

Study shows how pseudogenes can regulate activity of PTEN cancer-related gene

Small stretches of DNA in the human genome are known as "pseudogenes" because, while their sequences are nearly identical to those of various genes, they have long been thought to be non-coding "junk" DNA.

25 Feb 2013

Researchers identify new pseudogene that regulates tumour-suppressing PTEN

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumour-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumour process, make the cancer tumour more sensitive to chemotherapy and to prevent the development of resistance.

25 Feb 2013

WUSTL to develop 3-D computer models of brain biomechanics to better understand TBI

Washington University in St. Louis engineering researchers have received a five-year, $2.25 million grant to better understand traumatic brain injuries in efforts to improve methods for prevention and treatment.

25 Feb 2013

Orphan, CU to develop enzyme replacement therapy for CBS-deficient homocystinuria

The University of Colorado (CU) has signed exclusive, worldwide licensing and collaboration agreements with rare-disease research-and-development firm Orphan Technologies Ltd to develop an enzyme replacement therapy for Cystathionine Beta-Synthase (CBS) -deficient homocystinuria, a rare, inherited metabolic disease that is often fatal at a young age.

25 Feb 2013

Researchers discover new way to accelerate mass spectrometer that identifies proteins

Researchers at the University of Wisconsin-Madison have found a new way to accelerate a workhorse instrument that identifies proteins. The high-speed technique could help diagnose cancer sooner and point to new drugs for treating a wide range of conditions.

25 Feb 2013

Scientists identify mechanosensitive cellular signaling pathway in myofibroblasts

Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxygen to the blood stream, and, eventually, heart failure.

24 Feb 2013

A good night's sleep can also help promote cardiovascular health

Cutting back on sodium and increasing physical activity are not the only ways to improve heart health - a good night's sleep can also help promote cardiovascular health. One expert at the University of Alabama at Birmingham (UAB) says not getting enough sleep can have harmful heart-health effects.

24 Feb 2013

Researchers identify new function for matriptase enzyme

Dr. Martin Richter (pharmacology), investigator with the Centre de recherche clinique Étienne-Le Bel (CRCELB) at the Centre hospitalier universitaire de Sherbrooke (CHUS) and professor in the Faculty of Medicine and Health Sciences of the Université de Sherbrooke (UdeS), and his collaborators have identified a new function of the enzyme matriptase, present in the human respiratory system, that can activate a viral protein involved in infections caused by the H1N1 influenza (or flu) virus.

24 Feb 2013

New, effective and less toxic therapeutic option for patients with HER2-positive breast cancer

Patients with HER2-positive breast cancer, a particularly aggressive form of breast cancer, now have a new, effective and less toxic therapeutic option.

24 Feb 2013

HIF-1α protein can work directly to stop new cells from forming

A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying - known as DNA replication - and new cell growth to many of the body's functions and in such diseases as cancer.

23 Feb 2013

Genentech receives FDA approval for Kadcyla to treat HER2-positive metastatic breast cancer

The U.S. Food and Drug Administration today approved Kadcyla (ado-trastuzumab emtansine), a new therapy for patients with HER2-positive, late-stage (metastatic) breast cancer.

23 Feb 2013

Leading cancer researcher, Dr. Lewis Cantley, named a winner of the inaugural Breakthrough Prize in Life Sciences

Dr. Lewis Cantley, a leading cancer researcher credited with discovering a family of enzymes fundamental to understanding cancer, was named a winner of the inaugural Breakthrough Prize in Life Sciences, the world’s richest academic prize for medicine and biology. The prize, which carries a $3 million cash award, recognizes excellence in research aimed at curing intractable diseases and human life.

22 Feb 2013

Protein News and Research

Further Reading

Loss of Dickopf-1 restores neurogenesis and memory in animal model

Researchers improve NanoVelcro device to better grab cancer cells as blood passes by them

Recombinant Newcastle disease virus kills all kinds of prostate cancer cells

Experts analyse biological function of Shewanella-like protein phosphatase

HDAC-mediated mechanisms play critical role in regulating lung repair and regeneration

High life inadvisable after Fontan procedure

Ampio to initiate dose escalation run-in study for treatment of knee osteoarthritis

Researchers map complex interactions of proteins that control inflammation

Study shows how pseudogenes can regulate activity of PTEN cancer-related gene

Researchers identify new pseudogene that regulates tumour-suppressing PTEN

WUSTL to develop 3-D computer models of brain biomechanics to better understand TBI

Orphan, CU to develop enzyme replacement therapy for CBS-deficient homocystinuria

Researchers discover new way to accelerate mass spectrometer that identifies proteins

Scientists identify mechanosensitive cellular signaling pathway in myofibroblasts

A good night's sleep can also help promote cardiovascular health

Researchers identify new function for matriptase enzyme

New, effective and less toxic therapeutic option for patients with HER2-positive breast cancer

HIF-1α protein can work directly to stop new cells from forming

Genentech receives FDA approval for Kadcyla to treat HER2-positive metastatic breast cancer

Leading cancer researcher, Dr. Lewis Cantley, named a winner of the inaugural Breakthrough Prize in Life Sciences

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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