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Researchers develop novel chemo-immunotherapy agent to treat pancreatic tumors

Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis.

6 Nov 2020

Deciphering heart-brain talk may help unlock the key to cardiovascular disease

The crosstalk of the heart and brain is continuous and deciphering those messages may help researchers unlock the key to cardiovascular disease, says Deeptankar DeMazumder, MD, PhD, assistant professor in the University of Cincinnati College of Medicine.

6 Nov 2020

Blood vessel malformations originate in vein cells

In the condition known as cavernoma, lesions arise in a cluster of blood vessels in the brain, spinal cord or retina. Researchers from Uppsala University can now show, at molecular level, that these changes originate in vein cells.

3 Nov 2020

SARS-CoV-2 spike proteins can directly impact the blood-brain barrier

Like a key, SARS-CoV-2 - the virus that causes coronavirus disease 2019 (COVID-19) - attaches to specific molecules on the host cell surface, opening gateways into the cell interior.

30 Oct 2020

UH and CWRU announce Phase 3 trial of Astrazeneca's investigational COVID-19 vaccine

University Hospitals and Case Western Reserve University announced today that UH Cleveland Medical Center has been selected as a clinical trial site for the Phase 3 global study of an investigational vaccine against SARS-CoV-2, sponsored by AstraZeneca.

29 Oct 2020

Study suggests new strategies to prevent complications in cardiac patients

Patients in cardiac intensive care units (CICUs) could benefit from the CICU health care team using a daily checklist to prevent infections and other common complications.

29 Oct 2020

Novel device can benefit patients with upper limb paralysis

A tiny device the size of a small paperclip has been shown to help patients with upper limb paralysis to text, email and even shop online in the first human trial.

29 Oct 2020

New report offers guidance on cardiac screening of athletes infected with COVID-19

Reports have indicated that COVID-19 may cause heart damage in hospitalized patients with severe cases of the disease, but it's unclear whether cardiac injury also occurs in infected patients who are asymptomatic or experience only mild symptoms.

29 Oct 2020

Brain-computer interface enables patients with severe paralysis to resume daily tasks

Researchers demonstrated the success of a fully implantable wireless medical device, the Stentrode™ brain-computer interface (BCI), designed to allow patients with severe paralysis to resume daily tasks -- including texting, emailing, shopping and banking online -- without the need for open brain surgery.

28 Oct 2020

A systematic review and meta-analysis of stroke in COVID-19 patients

Fourteen out of every 1,000 COVID-19 patients admitted to hospital experience a stroke, a rate that is even higher in older patients and those with severe infection and pre-existing vascular conditions, according to a report published this week.

28 Oct 2020

Sleep could be targeted to improve post-stroke recovery, study shows

Until today neurorehabilitation is the only approach that promotes recovery after stroke. Researchers at the Neurology Department of the University of Bern and Inselspital have provided first evidence that sleep could be targeted to improve post-stroke recovery.

28 Oct 2020

Novel mechanism increases arterial diameter, allows increased inflow

Upon a heart infarct or stroke, rapid restoration of blood flow, and oxygen delivery to the hypoperfused regions is of eminent importance to prevent further damage to the heart or brain. Arterial diameter is a critical determinant of blood flow conductance.

28 Oct 2020

Researchers generate a transcriptomic map of the COVID brain

COVID-19 is known to be associated with multiple changes in gene expression, but many of these are also seen in chronic brain conditions as well as in some abnormal mental conditions. A recent study published on the preprint server bioRxiv in October 2020 uncovers the molecular basis of this association.

26 Oct 2020

NRP-1 receptor potentiates SARS-CoV-2 infectivity

The COVID-19 pandemic is still actively spreading in many parts of the world, causing redoubled efforts to develop antivirals and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A recent study explores the role of a second type of cell surface receptor, called neuropilin, in the virus's entry into the host cell and its subsequent replication.

26 Oct 2020

Researchers receive $2+ million grant to study acupuncture in emergency departments

Jeffery Dusek, PhD, Director of Research at University Hospitals (UH) Connor Integrative Health Network and Associate Professor in the Department of Family Medicine and Community Health at Case Western Reserve University, and colleagues were recently awarded a 3-year, $2+ million grant from the National Center of Complementary and Integrative Health, part of the National Institutes of Health.

22 Oct 2020

Novel tool can provide rapid stroke diagnosis from interaction with a smartphone

A new tool created by researchers at Penn State and Houston Methodist Hospital could diagnose a stroke based on abnormalities in a patient's speech ability and facial muscular movements, and with the accuracy of an emergency room physician -- all within minutes from an interaction with a smartphone.

22 Oct 2020

Study reveals why oxygen deficiency impairs brain cells

Brain cell dysfunction in low oxygen is, surprisingly, caused by the very same responder system that is intended to be protective, according to a new published study by a team of researchers at the Case Western Reserve University School of Medicine.

22 Oct 2020

Serious ongoing symptoms in COVID-19 survivors

Although predominantly a respiratory illness, emerging data suggests that multi-organ injury is common, particularly in moderate to severe infections. A new study published on the preprint server medRxiv* in October 2020 describes the illness's sequelae in the months after recovery.

20 Oct 2020

Study tackles the role of the renin-angiotensin system on COVID-19 pathophysiology

Vinicius Novaes Rocha, a researcher at the Federal University of Juiz de Fora in Brazil, provides an insight into the role of the renin-angiotensin on the pathophysiology of COVID-19, paving the way for developing new treatment methods in the journal Medical Hypotheses.

19 Oct 2020

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

As the COVID-19 pandemic progresses with little prospect of immediate relief, a recent study by Johns Hopkins University researchers published on the preprint server medRxiv* in October 2020 discusses the association of Immunoglobulin M (IgM) autoantibodies against the host receptor that binds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with severe disease via vascular endothelial damage. This could help develop better therapies and prognostic criteria.

19 Oct 2020