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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Efficient, sensitive and robust Chromatin immunoprecipitation methods

Chromatrap®, a business unit of Porvair Sciences, has produced a new 10-page brochure that provides an informative introduction to chromatin immunoprecipitation (ChIP) technology and a detailed comparison of traditional bead based and Chromatrap® solid state ChIP technologies.

From Chromatrap® - Porvair Sciences Ltd 14 Jul 2015

Paul G. Allen Family Foundation announces ADI grants for Alzheimer's disease research

The Paul G. Allen Family Foundation announced today the award of Allen Distinguished Investigator (ADI) grants to five teams of researchers with projects that will open new and innovative avenues of research in Alzheimer's disease by uncovering its elusive biological roots.

14 Jul 2015

Isis Pharmaceuticals receives $2.15 million milestone payment to advance ISIS-SMN Rx study in children with SMA

Isis Pharmaceuticals, Inc. announced today that it has earned a $2.15 million milestone payment from Biogen related to advancing the ongoing pivotal Phase 3 study (CHERISH) evaluating ISIS-SMN Rx in children with spinal muscular atrophy (SMA).

14 Jul 2015

Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

The best-known genetic variant linked to Alzheimer's disease may be "at work" promoting deposits of plaque in the brain long before any symptoms of the disease can be measured on tests, according to a national research study led by Indiana University School of Medicine investigators.

14 Jul 2015

Researchers discover new mechanism that regulates size of human cells

Every cell in the human body has to be a particular size in order to function correctly. The research group led by Markus Hengstschläger of the Institute for Medical Genetics at the Medical University of Vienna has now discovered a new mechanism that regulates cell size.

14 Jul 2015

Study finds gene linked to age-related obesity, diabetes

Practically everyone gets fatter as they get older, but some people can blame their genes for the extra padding. Researchers have shown that two different mutations in a gene called ankyrin-B cause cells to suck up glucose faster than normal, fattening them up and eventually triggering the type of diabetes linked to obesity.

14 Jul 2015

Stopping cocaine use may lower levels of ET-1 protein that plays key role in coronary artery disease

For people who use cocaine, stopping or reducing cocaine use is associated with decreased levels of endothelin-1 (ET-1)--a protein that plays a key role in the development of coronary artery disease, reports a study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine.

14 Jul 2015

Biosimilars show promise for children with IBD, but more research needed

Children with inflammatory bowel disease (IBD) who are doing well on specific biological medications should not be switched to recently approved "biosimilar" products, concludes an expert consensus statement of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition.

14 Jul 2015

New understanding of keratin 17 protein could lead to development of better ways to prevent cancer

New research from the Johns Hopkins Bloomberg School of Public Health suggests that the protein keratin 17 - the presence of which is used in the lab to detect and stage various types of cancers - is not just a biomarker for the disease, but may play a critical role in tumor growth.

14 Jul 2015

UM researchers discover new gene behind neurodegenerative conditions

Researchers at the University of Miami have discovered and characterized a previously unknown disease gene linked to the degeneration of optic and peripheral nerve fibers. The study titled "Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder" is published in the journal Nature Genetics.

14 Jul 2015

Gene function in the human brain could help reveal basis of autism

UNSW Australia scientists have discovered a link between autism and genetic changes in some segments of DNA that are responsible for switching on genes in the brain.

14 Jul 2015

Researchers identify protein responsible for preserving antibody-producing cells that lead to long-term immunity

Melbourne researchers have identified a protein responsible for preserving the antibody-producing cells that lead to long-term immunity after infection or vaccination.

14 Jul 2015

Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

US-Australian drug discovery company, Novogen Limited, today announced details of an in vivo proof of concept study that demonstrates their lead anti-tropomyosin drug candidate, Anisina, has the potential to improve the effectiveness of chemotherapy in children and reduce life-long side-effects.

14 Jul 2015

OncoGenex's custirsen Phase 3 ENSPIRIT trial for treatment of NSCLC patients continues as planned

OncoGenex Pharmaceuticals, Inc. announced today that its Phase 3 ENSPIRIT trial evaluating custirsen in the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) is continuing as planned per the recommendation of an Independent Data Monitoring Committee (IDMC). This decision was based upon completion of the second and final planned interim futility analysis.

13 Jul 2015

Researchers discover role of RORC mutations in patients with candidiasis and mycobacteriosis

The discovery of bi-allelic mutations in RORC in patients with candidiasis and mycobacteriosis revealed the pivotal role of RORC in mucocutaneous immunity to Candida and in systemic immunity to Mycobacterium in humans.

13 Jul 2015

Study offers new way to suppress growth factors related to cancer cell proliferation

Cancer cells need life-essential molecules to proliferate. These so-called growth factors are activated by ectodomain shedding of precursor proteins on the outside of the plasma membrane, mainly carried out by three human cleavage enzymes. A pharmaceutical blocking of these enzymes could hinder cancer from growing but would also inhibit other life-essential processes.

13 Jul 2015

Cysticercosis now fully controlled in Mexico

Dr. Ana Flisser was recognized for 40 years of research regarding this disease. The parasite can not be eradicated; however, it is important to present simple preventive measures.

13 Jul 2015

Canadian researchers launch world's first viral therapy clinical trial to attack and kill cancer cells

Canadian researchers have launched the world's first clinical trial of a novel investigational therapy that uses a combination of two viruses to attack and kill cancer cells, and stimulate an anti-cancer immune response. Previous research by this team and others worldwide suggests that this approach could be very powerful, and could have fewer side effects than conventional chemotherapy and radiation, although it will take years to rigorously test through this trial and others.

13 Jul 2015

New cell structure discovery could help scientists understand cancer development

University of Warwick researchers have discovered a cell structure which could help scientists understand why some cancers develop.

12 Jul 2015

IMBRUVICA (ibrutinib) approved in Europe for treatment of Waldenstrom's macroglobulinemia

Today AbbVie announced the European Commission granted marketing authorization for IMBRUVICA (ibrutinib) as the first treatment option available in all 28 member states of the European Union for the treatment of Waldenstrom's macroglobulinemia (WM), a rare, slow growing blood cancer, in adult patients who have received at least one prior therapy, or in first line treatment for patients unsuitable for chemo-immunotherapy.

12 Jul 2015

Protein News and Research

Further Reading

Efficient, sensitive and robust Chromatin immunoprecipitation methods

Paul G. Allen Family Foundation announces ADI grants for Alzheimer's disease research

Isis Pharmaceuticals receives $2.15 million milestone payment to advance ISIS-SMN Rx study in children with SMA

Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

Researchers discover new mechanism that regulates size of human cells

Study finds gene linked to age-related obesity, diabetes

Stopping cocaine use may lower levels of ET-1 protein that plays key role in coronary artery disease

Biosimilars show promise for children with IBD, but more research needed

New understanding of keratin 17 protein could lead to development of better ways to prevent cancer

UM researchers discover new gene behind neurodegenerative conditions

Gene function in the human brain could help reveal basis of autism

Researchers identify protein responsible for preserving antibody-producing cells that lead to long-term immunity

Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

OncoGenex's custirsen Phase 3 ENSPIRIT trial for treatment of NSCLC patients continues as planned

Researchers discover role of RORC mutations in patients with candidiasis and mycobacteriosis

Study offers new way to suppress growth factors related to cancer cell proliferation

Cysticercosis now fully controlled in Mexico

Canadian researchers launch world's first viral therapy clinical trial to attack and kill cancer cells

New cell structure discovery could help scientists understand cancer development

IMBRUVICA (ibrutinib) approved in Europe for treatment of Waldenstrom's macroglobulinemia

Ultimate guide to the essential tools for the characterization of proteins, polymers and nanoparticles eBook

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