Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

BioLineRx reports positive results from pre-clinical trials with RHB-104 for treatment of thrombocytopenia

BioLineRx, a biopharmaceutical development company, announced today that BL-8040 has been shown in pre-clinical trials to be effective for the treatment of thrombocytopenia, or reduced platelet production.

5 Aug 2013

Researchers identify precise method for determining bone marrow involvement in DLBCL patients

A more precise method for determining bone marrow involvement in patients with diffuse large B-cell lymphoma-a key factor in tailoring patient management plans-has been identified by researchers in a study published in the August issue of The Journal of Nuclear Medicine.

2 Aug 2013

Study offers new hope for treatment of diffuse large B-cell lymphoma

Researchers have discovered how an experimental drug is capable of completely eradicating human lymphoma in mice after just five doses. The study, led by researchers at Weill Cornell Medical College, sets the stage for testing the drug in clinical trials of diffuse large B-cell lymphoma, the most common subtype of non-Hodgkin lymphoma, itself the seventh most frequently diagnosed cancer in the U.S.

2 Aug 2013

Researchers reveal location of human blood stem cells that may improve bone marrow transplants

McMaster University researchers have revealed the location of human blood stem cells that may improve bone marrow transplants. The best stem cells are at the ends of the bone.

2 Aug 2013

Cambridge scientists identify molecular 'on/off' switch in malignant germ cell tumours

Cambridge scientists have identified an 'on/off' switch in a type of cancer which typically occurs in the testes and ovaries called 'malignant germ cell tumours'. The research was published today, 01 August, in the journal Cancer Research.

1 Aug 2013

Finding could influence effectiveness of bone marrow transplants for late-stage leukemia

Eight years ago, two former Stanford University postdoctoral fellows, one of them still in California and the other at the Harvard Stem Cell Institute in Cambridge, began exchanging theories about why patients with leukemia stop producing healthy blood cells. What was it, they asked, that caused bone marrow to stop producing normal blood-producing cells?

1 Aug 2013

Researchers identify stem cells in urine can be directed to become multiple cell types

Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem cells in urine that can be directed to become multiple cell types.

31 Jul 2013

CHOP researchers advance stem cell studies in childhood leukemia, Diamond Blackfan anemia

First produced only in the past decade, human induced pluripotent stem cells are capable of developing into many or even all human cell types. In new research, scientists reprogrammed skin cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these cells in advancing understanding of those challenging diseases-and eventually in treating them.

31 Jul 2013

Research findings provide insight into safety of central line uses outside hospital

Pediatric cancer patients whose central lines are used to treat them at home develop three times as many dangerous bloodstream infections from their devices than their hospitalized counterparts, according to the results of a new Johns Hopkins Children's Center study.

25 Jul 2013

Manchester scientists treat fatal genetic brain disease using stem cell gene therapy

Scientists from The University of Manchester have used stem cell gene therapy to treat a fatal genetic brain disease in mice for the first time.

From The University of Manchester 25 Jul 2013

Randomized trial examines purging of tumor cells from stem cells prior to transplantation in neuroblastoma patients

Judith Villablanca, MD, of The Saban Research Institute of Children's Hospital Los Angeles, Susan Kreissman, MD, of Duke University Medical Center, and colleagues reported the results of a randomized, phase 3 clinical trial conducted by the Children's Oncology Group examining the effect of selectively removing (purging) tumor cells from blood stem cells before they are transplanted back into patients with high-risk neuroblastoma following high-dose chemotherapy.

25 Jul 2013

State highlights: Medicaid pilot project costs $32B more than expected

A selection of health policy stories from the District of Columbia, New York, Georgia, Minnesota, Illinois, North Carolina, Colorado and California.

24 Jul 2013

SCCA physicians honored as "Top Doctors" for providing outstanding cancer care

Seattle Cancer Care Alliance doctors were recently honored by a judging panel of their peers for providing outstanding cancer care.

24 Jul 2013

Research team receives NCI grant to develop precision therapies that kill cancer cells

A research team headed by Fred Hutchinson Cancer Research Center scientists Christopher Kemp, Ph.D., and Carla Grandori, M.D., Ph.D., has received a $4 million grant from the National Cancer Institute to develop precision therapies that selectively kill cancer cells while sparing normal, healthy tissue.

24 Jul 2013

Genentech announces that Phase III CLL11 study meets primary endpoint

Genentech, a member of the Roche Group, today announced positive results from the Phase III CLL11 study. At a pre-planned interim analysis, an independent data monitoring committee determined that the study met its primary endpoint showing that GA101 plus chlorambucil helped people live significantly longer without their disease worsening (progression-free survival; PFS) compared to Rituxan (rituximab) plus chlorambucil.

24 Jul 2013

Mirror Effect of Immunovative Therapies: A new approach to cancer treatment

Dr. Michael Har-Noy, founder and CEO of Immunovative Therapies Ltd, a biotech company in Israel, describes a new and unique approach to cancer treatment.

20 Jul 2013

Spectrum Pharmaceuticals enters into agreement to acquire Talon Therapeutics

Spectrum Pharmaceuticals, Inc., a biotechnology company with fully-integrated commercial and drug development operations with a primary focus in hematology and oncology, today announced that, through a wholly-owned subsidiary, the company entered into an agreement to acquire Talon Therapeutics, Inc., a biopharmaceutical company based in South San Francisco, California, and expects to complete the acquisition within one day.

17 Jul 2013

Magnets could be used for directing stem cells, may help treat heart and vascular diseases

Magnets could be a tool for directing stem cells' healing powers to treat conditions such as heart disease or vascular disease.

17 Jul 2013

Blood vessels grown from pluripotent stem cells able to function inside mice

Researchers at Johns Hopkins have coaxed stem cells into forming networks of new blood vessels in the laboratory, then successfully transplanted them into mice. The stem cells are made by reprogramming ordinary cells, so the new technique could potentially be used to make blood vessels genetically matched to individual patients and unlikely to be rejected by their immune systems, the investigators say.

17 Jul 2013

Discovery of hybrid cells in human melanoma

The University of Colorado Cancer Center along with Yale University and the Denver Crime Lab report in the journal PLOS ONE the first proof of cancer's ability to fuse with blood cells in a way that gives cancer the ability to travel, allowing previously stationary cancer cells to enter the bloodstream and seed sites of metastasis around the body.

16 Jul 2013

Bone Marrow News and Research

Further Reading

BioLineRx reports positive results from pre-clinical trials with RHB-104 for treatment of thrombocytopenia

Researchers identify precise method for determining bone marrow involvement in DLBCL patients

Study offers new hope for treatment of diffuse large B-cell lymphoma

Researchers reveal location of human blood stem cells that may improve bone marrow transplants

Cambridge scientists identify molecular 'on/off' switch in malignant germ cell tumours

Finding could influence effectiveness of bone marrow transplants for late-stage leukemia

Researchers identify stem cells in urine can be directed to become multiple cell types

CHOP researchers advance stem cell studies in childhood leukemia, Diamond Blackfan anemia

Research findings provide insight into safety of central line uses outside hospital

Manchester scientists treat fatal genetic brain disease using stem cell gene therapy

Randomized trial examines purging of tumor cells from stem cells prior to transplantation in neuroblastoma patients

State highlights: Medicaid pilot project costs $32B more than expected

SCCA physicians honored as "Top Doctors" for providing outstanding cancer care

Research team receives NCI grant to develop precision therapies that kill cancer cells

Genentech announces that Phase III CLL11 study meets primary endpoint

Mirror Effect of Immunovative Therapies: A new approach to cancer treatment

Spectrum Pharmaceuticals enters into agreement to acquire Talon Therapeutics

Magnets could be used for directing stem cells, may help treat heart and vascular diseases

Blood vessels grown from pluripotent stem cells able to function inside mice

Discovery of hybrid cells in human melanoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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