Analgesia News and Research

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Surprises found in postoperative pain rankings

Patients report “unexpectedly high” levels of pain after some relatively minor surgical procedures, including some laparoscopic procedures, say researchers.

15 Feb 2013

LASAG trial for severe influenza initiated

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12 Feb 2013

Sympathetic nervous system implicated in acupuncture analgesia

Acupuncture appears to activate the sympathetic nervous system in people experiencing pain, a randomized study indicates.

6 Feb 2013

Patients undergoing major vascular surgery procedures are at increased risk of stroke

Patients undergoing major vascular surgery procedures are at increased risk of stroke, leading to a high mortality rate and prolonged hospitalization, according to a study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

6 Feb 2013

Regular exercise reduces development of painful diabetic neuropathy in animals

Regular exercise reduces the development of painful diabetic neuropathy in animals—apparently related to increased expression of a protective substance called "heat shock protein" 72 (Hsp72), reports an experimental study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

5 Feb 2013

‘Imperfect’ test for misplaced epidural catheter studied

A reduced dose of lidocaine may have advantages over a standard dose for detecting inadvertent intrathecal catheter placement during epidural anesthesia, but neither is wholly reliable, say researchers.

25 Jan 2013

Neuromuscular blockade (NMB) reversal

General anesthesia is made up of three components: hypnotic medicines, to induce sleep; analgesics, or medicines to inhibit pain; and NMB agents that induce muscle relaxation. Anesthesiology professionals use NMB to relax a patient’s muscles and prevent involuntary movement that could impact surgery.

24 Jan 2013

Morphine not first choice after neonatal surgery

Neonates and infants undergoing major surgery should be treated with postoperative intermittent intravenous acetaminophen as opposed to continuous morphine, research suggests.

14 Jan 2013

Electroconvulsive therapy releases opiate-like substances

Researchers used electricity on certain regions in the brain of a patient with chronic, severe facial pain to release an opiate-like substance that's considered one of the body's most powerful painkillers.

3 Jan 2013

Study suggests genetic component in pain response among children

At least two common gene variants are linked to "clinically meaningful" differences in pain scores in children after major surgery, reports a study in the January issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

25 Dec 2012

‘Sensory’ block promise for postop knee pain

Using adductor canal block rather than femoral nerve block for analgesia after knee surgery could minimize muscle weakness and risk for falls, a study in Anesthesiology suggests.

19 Dec 2012

AcelRx announces top-line data from Sufentanil NanoTab PCA System Phase 3 trial

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today announced that top-line data from its previously announced open-label, active-comparator study of its lead product candidate, the Sufentanil NanoTab PCA System, will be featured in poster presentations to be held at the 66th annual New York State Society of Anesthesiologists PostGraduate Assembly meeting in New York City to be held December 14-18, 2012.

15 Dec 2012

New technology allows noninvasive SpHb assessments for children undergoing brain surgery

For children undergoing brain surgery, a new technology allows noninvasive, continuous monitoring of blood hemoglobin levels, according to a study in the December issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

6 Dec 2012

No serious complications of regional nerve blocks in children

A review of more than 15,000 nerve block procedures performed in children at U.S. hospitals finds little or no risk of permanent complications or death, reports a study in the December issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

6 Dec 2012

Anesthesia & Analgesia Case Reports to be published in 2013

A new journal dedicated to sharing and discussion of informative clinical experiences is coming soon, with the launch of Anesthesia & Analgesia Case Reports, the newest publication of the International Anesthesia Research Society (IARS).

17 Nov 2012

Cartoons effectively reduce preoperative anxiety in children

Letting children watch a favorite cartoon is an effective and safe way to reduce anxiety before anesthesia and surgery, concludes a study in the November issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

6 Nov 2012

AcelRx commences dosing in ARX-04 sufentanil NanoTab Phase 2 study for acute and breakthrough pain

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today announced that it has dosed the first subjects in a Phase 2, placebo-controlled, dose-finding study of its ARX-04 sufentanil NanoTab product candidate.

5 Nov 2012

TD-1211 may relieve opioid-induced constipation

TD-1211 – an inhibitor of the mµ-opioid receptor – alleviates chronic noncancer-related constipation in patients receiving opioid therapy, without affecting pain relief, show the results of a parallel-group study.

2 Nov 2012

Video can effectively reduce anxiety in children undergoing inhaled induction

Research by Dalhousie University student Katherine Mifflin has found that having children watch a video immediately prior to surgery can reduce their anxiety during anesthesia induction, the most stressful time for children throughout the perioperative process.

1 Nov 2012

Orexo initiates OX51 Phase II trial in patients undergoing prostate biopsy

Swedish specialty pharmaceutical company Orexo today communicated the start of the dose finding study for OX51 in patients undergoing prostate biopsy.

31 Oct 2012