Pathophysiology News and Research

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New support for a serotonin deficit in depression

Since the 1960s, researchers have postulated that major depression stems from disruptions in the serotonin neurotransmitter system, but the evidence for that idea, though plentiful, was indirect.

16 Dec 2022

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Necroptosis is a form of regulated cell death (RCD) similar to apoptosis, the most commonly studied type of RCD. In contrast to apoptosis, plasma membrane rupture in necroptotic cells occurs at early time points.

9 Dec 2022

Genetic predisposition to ADHD can predict risk of late-onset Alzheimer's disease

Genetic predisposition to attention-deficit/hyperactivity disorder (ADHD) can predict cognitive decline and Alzheimer's disease later in life, revealed an analysis published today in Molecular Psychiatry by University of Pittsburgh School of Medicine researchers.

8 Dec 2022

Machine learning analysis suggests that there are four sub-phenotypes of long COVID

Researchers identified PASC [post-acute sequelae of coronavirus disease 2019 (COVID-19)] sub-phenotypes depending on conditions diagnosed within 1 to 3 months of acute infection by SARS-CoV-2.

6 Dec 2022

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Researchers investigated the clinical, histopathological, imaging, and serological characteristics of post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in patients with mild COVID-19.

5 Dec 2022

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Researchers evaluated blood plasma proteins to identify new targets for COVID-19 treatment approaches and prevent complications associated with severe illness.

5 Dec 2022

Powerful imaging tool creates 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions

Gross anatomy reveals three-dimensional shapes of pathology at a large scale. Histology, in contrast, reveals the microscopic anatomy of biological structures. But that magnification comes at a cost -; histology shows only two-dimensional shapes because it studies small, flat slices of stained tissue.

29 Nov 2022

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Researchers evaluated neuro-pathophysiological consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, especially the post-acute sequelae of SARS-CoV-2 (PASC) in Alzheimer’s disease (AD) patients.

28 Nov 2022

Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

Addressing this gap in research, a recent Nature Medicine study hypothesized that 4R isoform-specific MTBR-tau species accumulate in the patient’s brain of specific subtypes of 4R tauopathies.

28 Nov 2022

The distinct pathophysiology of ‘SuperAger’ brains

Superagers are adults over the age of 80 who have a superior memory capacity that resembles that of middle-aged adults.

27 Nov 2022

Biologic therapy for IBD patients through a financial assistance program could have superior outcomes

Patients with inflammatory bowel diseases (IBD) who required treatment with biologic therapies and were enrolled in a financial assistance program were less likely to need surgery after starting medication than those not enrolled in a program, a study by UT Southwestern researchers found.

23 Nov 2022

Study explores link between dynamic changes in metabolic syndrome and risk of gout

In a study published in Arthritis & Rheumatology that included nearly 1.3 million men aged 20–39 years who participated in three serial health check-ups at two-year intervals, men with metabolic syndrome (MetS) and those who developed MetS-;especially those with the MetS components of elevated triglycerides and abdominal obesity-;had higher risks of developing gout.

23 Nov 2022

The binding and functional serologic responses to COVID-19 vaccination in children with history of MIS-C

Researchers evaluated the serological responses elicited by COVID-19 vaccinations in children who developed MIS-C following a previous SARS-CoV-2 infection.

23 Nov 2022

Omicron BA.2 causes more symptoms and a greater disruption to daily life

In a recent study published in the Nature Communications journal, researchers monitored the changing symptom profiles associated with different severe acute respiratory syndrome CoV-2 (SARS-CoV-2) variants, especially Omicron subvariants BA.1 and BA.2.

16 Nov 2022

Ketogenic diet may show more promising results than Mediterranean diets in short-term type 2 diabetes management

Researchers evaluated the short-term impact of the very-low-calorie ketogenic diet (VLCKD) and Mediterranean diet (MD) on the gut microbiota (GM) of obese patients with new-onset type II diabetes (T2DM).

15 Nov 2022

Do SSRIs lower the risk of long COVID?

Researchers conducted a retrospective study to determine whether SSRIs with immunomodulatory and antiplatelet properties can decrease the risk of post-acute sequelae of COVID-19 (PASC).

15 Nov 2022

Multinational consensus to end COVID-19 pandemic

A new study recommended specific actions to end the coronavirus disease 2019 (COVID-19) pandemic.

7 Nov 2022

Survival rates increased among children who experienced in-hospital cardiac arrest in the last 20 years

Among children who experienced in-hospital cardiac arrest in the last 20 years, survival rates have increased significantly.

31 Oct 2022

Smartphone code blue notification may accelerate response to in-hospital cardiac arrest

Sixty seconds can make or break the outcome of a hospital "code blue" or cardiac arrest response. New research found a hospital code response team rushing to a patient in cardiac arrest may arrive at least one minute quicker and may also lead to better patient outcomes with the use of a smartphone emergency code notification system that activates the team through text messages.

31 Oct 2022

ICU evaluation before cardiac arrest improves survival rates by 15% among Black people

Although racial disparities in survival after in-hospital cardiac arrest among Black and white people are known, both groups had similar chances of receiving an intensive care unit (ICU) evaluation before a cardiac arrest.

31 Oct 2022

Pathophysiology News and Research

New support for a serotonin deficit in depression

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Genetic predisposition to ADHD can predict risk of late-onset Alzheimer's disease

Machine learning analysis suggests that there are four sub-phenotypes of long COVID

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Powerful imaging tool creates 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

The distinct pathophysiology of ‘SuperAger’ brains

Biologic therapy for IBD patients through a financial assistance program could have superior outcomes

Study explores link between dynamic changes in metabolic syndrome and risk of gout

The binding and functional serologic responses to COVID-19 vaccination in children with history of MIS-C

Omicron BA.2 causes more symptoms and a greater disruption to daily life

Ketogenic diet may show more promising results than Mediterranean diets in short-term type 2 diabetes management

Do SSRIs lower the risk of long COVID?

Multinational consensus to end COVID-19 pandemic

Survival rates increased among children who experienced in-hospital cardiac arrest in the last 20 years

Smartphone code blue notification may accelerate response to in-hospital cardiac arrest

ICU evaluation before cardiac arrest improves survival rates by 15% among Black people

Changing the landscape of R&D to build clinical success from the ground up

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

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