RNA Sequencing News and Research

RSS

Transcription factors SP5 and SP8 regulate primary cilia formation in embryos

Some might say it looks like a finger. Others might see a worm. Scientists in the field often liken it to an antenna.

29 Aug 2025

Male and female bovine embryos show distinct development paths

Cornell researchers have uncovered the genetic triggers that cause male and female bovine embryos to develop differently, as early as seven to eight days after fertilization.

29 Aug 2025

Signaling mechanisms driving olfactory neurogenesis in zebrafish

Cellular differentiation of stem cells into specialized cells requires many steps, including division, to create more cells; fate determination, which is a commitment to a specific lineage or developmental path; and migration, to integrate the cell into its final location.

29 Aug 2025

Stress in mothers causes eczema in newborn mice through immune cell changes

Maternal prenatal stress in mice disrupts fetal mast cell programming, triggering eczema-like skin inflammation and heightened sensitivity after birth. The findings reveal how corticosterone-driven immune and neuronal changes in utero may set the stage for pediatric eczema risk.

28 Aug 2025

Researchers develop novel exosome-based therapeutic agent for treating traumatic CNS injuries

Traumatic injuries of the central nervous system (CNS)-such as traumatic brain injury (TBI) and traumatic spinal cord injury (SCI)-are characterized by oxidative damage and neuroinflammation.

28 Aug 2025

Longitudinal study reveals how GLP-2 analog therapy transforms the intestinal environment

Researchers from Japan discover that glucagon-like peptide-2 (GLP-2) analogs can deeply and beneficially reshape the intestinal environment.

27 Aug 2025

Groundbreaking method captures microbial memory at the earliest stages of colony growth

Bacteria aren't just mindless microbes. New research from the Hebrew University of Jerusalem reveals that single bacterial cells can carry a "memory" of their past environments-passing it down through generations-before eventually forgetting.

26 Aug 2025

Diabetes-altered blood particles suppress immune defense in breast cancer

People with type 2 obesity-driven diabetes tend to have more aggressive breast cancers, but no one knows exactly why.

26 Aug 2025

AI tool reveals how TB drugs kill bacteria at the molecular level

Tuberculosis (TB) is the world's deadliest infectious disease—and one of the hardest to cure. Standard treatment requires a cocktail of multiple drugs over at least six months, and one in five patients have a type of TB that resists these first-line medications.

25 Aug 2025

New molecular mechanism offers hope for treating depression in the elderly

Major depressive disorder (MDD) is one of the most common psychiatric illnesses worldwide, but its molecular causes have still not been clearly identified.

25 Aug 2025

How a single gene reshapes pain perception through polyamine signaling

Researchers have identified SLC45A4 as a neuronal polyamine transporter genetically linked to human chronic pain. Loss of this gene in mice disrupts polyamine balance, alters spinal GABA levels, and reduces heat and tonic pain sensitivity.

24 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

Single-cell proteomic analysis uncovers hidden layers of blood cell formation

In the past decade there has been significant interest in studying the expression of our genetic code down to the level of single cells, to identify the functions and activities of any cell through the course of health or disease.

21 Aug 2025

Targeting the adrenomedullin pathway may be a potential therapy for liver failure

Liver failure syndromes are characterized by a dysregulated immune response leading to immune paralysis. Adrenomedullin (ADM) is a potent vasodilator and immunoregulator.

18 Aug 2025

Missing messenger RNA fragments unlock new immunotherapy targets in pediatric brain tumors

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

18 Aug 2025

Stem-like peripheral helper T cells found to sustain inflammation in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that affects millions worldwide and can have a devastating impact on patients' lives.

17 Aug 2025

Plasma proteomics study unlocks predictive biomarkers for TNBC immunotherapy

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies, making immunotherapy a promising yet unpredictable option.

17 Aug 2025

Researchers develop machine learning models to identify biomarkers for chronic fatigue syndrome

When cells expire, they leave behind an activity log of sorts: RNA expelled into blood plasma that reveal changes in gene expression, cellular signaling, tissue injury and other biological processes.

11 Aug 2025

Using machine learning framework to identify prognostic biomarkers in neuroblastoma

Neuroblastoma is the most common solid tumor in infants and accounts for nearly 15% of all pediatric cancer-related deaths.

11 Aug 2025

Decoding macrophage immune responses with gene editing and machine learning

Fighting off pathogens is a tour de force that must happen with speed and precision. A team of researchers at CeMM and MedUni Vienna led by Christoph Bock and Matthias Farlik has investigated how macrophages-immune cells that are the body's first responders-master this challenge.

8 Aug 2025

RNA Sequencing News and Research

Transcription factors SP5 and SP8 regulate primary cilia formation in embryos

Male and female bovine embryos show distinct development paths

Signaling mechanisms driving olfactory neurogenesis in zebrafish

Stress in mothers causes eczema in newborn mice through immune cell changes

Researchers develop novel exosome-based therapeutic agent for treating traumatic CNS injuries

Longitudinal study reveals how GLP-2 analog therapy transforms the intestinal environment

Groundbreaking method captures microbial memory at the earliest stages of colony growth

Diabetes-altered blood particles suppress immune defense in breast cancer

AI tool reveals how TB drugs kill bacteria at the molecular level

New molecular mechanism offers hope for treating depression in the elderly

How a single gene reshapes pain perception through polyamine signaling

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Single-cell proteomic analysis uncovers hidden layers of blood cell formation

Targeting the adrenomedullin pathway may be a potential therapy for liver failure

Missing messenger RNA fragments unlock new immunotherapy targets in pediatric brain tumors

Stem-like peripheral helper T cells found to sustain inflammation in rheumatoid arthritis

Plasma proteomics study unlocks predictive biomarkers for TNBC immunotherapy

Researchers develop machine learning models to identify biomarkers for chronic fatigue syndrome

Using machine learning framework to identify prognostic biomarkers in neuroblastoma

Decoding macrophage immune responses with gene editing and machine learning

Sequencing & Genomics: Elevating Science and Healthcare eBook

Latest eBooks

New horizons in drug discovery: High-throughput & target-to-therapy advances

A practical guide to lipid nanoparticle formulation and resizing

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology