Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

TTP488 slows cognitive decline in patients with mild to moderate Alzheimer's

A novel, orally administered drug candidate, TTP488, has demonstrated clinical evidence of slowing of cognitive decline over 18 months of therapy in patients with mild to moderate Alzheimer's disease.

30 Oct 2012

Positive results from Celldex’s CDX-1401 Phase 1 study on solid tumors

Celldex Therapeutics, Inc. today announced positive results demonstrating promising clinical effects in a Phase 1 study of CDX-1401 in solid tumors in combination with the toll-like receptor (TLR) agonists resiquimod and/or Poly ICLC.

30 Oct 2012

Scientists discover β2-syntrophin protein as new prognosis marker for prostate cancer

Scientists have discovered a molecular 'tell' in laboratory experiments that could help doctors determine the severity of a patient's prostate cancer.

30 Oct 2012

BioRx added to Zemaira distribution network

BioRx, a national specialty pharmacy and infusion services provider, has been added to the limited distribution network for Zemaira [alpha-1 proteinase inhibitor (human)]. Zemaira is indicated for chronic augmentation and maintenance therapy in individuals with alpha1-antitrypsin (AAT) deficiency and clinical evidence of emphysema.

30 Oct 2012

Scientists decode epigenetic programming of three virulent forms of acute lymphoblastic leukemia

A team of national and international researchers, led by Weill Cornell Medical College scientists, have decoded the key "software" instructions that drive three of the most virulent forms of acute lymphoblastic leukemia (ALL). They discovered ALL's "software" is encoded with epigenetic marks, chemical modifications of DNA and surrounding proteins, allowing the research team to identify new potential biomarkers and therapeutic targets.

29 Oct 2012

Researchers zero in on process by which stem cells maintain proper undifferentiated state

The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions, which are not well understood. Learning more about this process could prove useful for stem cell-based therapies down the road. New research from a team led by Carnegie's Yixian Zheng zeroes in on the process by which stem cells maintain their proper undifferentiated state.

29 Oct 2012

Light-sensitive protein to study Parkinson's disease

Introducing a light-sensitive protein in transgenic nerve cells... transplanting nerve cells into the brains of laboratory animals... inserting an optic fibre in the brain and using it to light up the nerve cells and stimulate them into releasing more dopamine to combat Parkinson's disease...

29 Oct 2012

Range of biopharma solutions from Malvern Instruments extended by distribution agreement with Affinity Biosensors

Materials characterization company Malvern Panalytical. (Malvern Panalytical, UK) has signed an exclusive distribution agreement with Affinity Biosensors LLC (Santa Barbara, CA, USA) which will extend the range of solutions that Malvern Panalytical offers to the biopharmaceutical sector.

From Malvern Panalytical 29 Oct 2012

Researchers learn how E2-79 molecule destroys complexes that induce allergic responses

Researchers have learned how a man-made molecule destroys complexes that induce allergic responses - a discovery that could lead to the development of highly potent, rapidly acting interventions for a host of acute allergic reactions.

29 Oct 2012

New therapy to treat rare form of cystic fibrosis works in unconventional way, scientists say

Scientists at the Hospital for Sick Children in Toronto have established that a drug recently approved by the U.S. Food and Drug Administration to treat a rare form of cystic fibrosis works in an unconventional way.

29 Oct 2012

Researchers identify genes linked to serous endometrial cancer

Researchers have identified several genes that are linked to one of the most lethal forms of uterine cancer, serous endometrial cancer.

29 Oct 2012

Idea of nuclear reprogramming holds promise for repairing damaged tissue

The idea of taking a mature cell and removing its identity (nuclear reprogramming) so that it can then become any kind of cell, holds great promise for repairing damaged tissue or replacing bone marrow after chemotherapy.

29 Oct 2012

Researchers use baker's yeast to identify new therapies for Lou Gehrig's disease

Amyotrophic lateral sclerosis, also called Lou Gehrig's disease, is a devastatingly cruel neurodegenerative disorder that robs sufferers of the ability to move, speak and, finally, breathe.

29 Oct 2012

New HIV test for babies differs from conventional test, delivers diagnosis in less than an hour

Today, mothers in Africa sometimes walk more than 10 miles to a clinic only to learn that conventional HIV test results for their babies are not available yet.

29 Oct 2012

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Doxorubicin, a 50-year-old chemotherapy drug still in widespread use against a variety of cancers, has long been known to destroy heart tissue, as well as tumors, in some patients.

29 Oct 2012

Researchers discover that bean commonly used in Chinese cuisine protects against sepsis

Researchers at The Feinstein Institute for Medical Research have discovered that a bean commonly used in Chinese cuisine protects against the life-threatening condition sepsis.

29 Oct 2012

Resistin protein causes high levels of bad cholesterol

Canadian scientists have discovered that a protein called resistin, secreted by fat tissue, causes high levels of "bad" cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease.

29 Oct 2012

Study demonstrates role of IRX4204 in alleviating cognitive decline in animal models of AD

New research presented in October at the 6th Neurodegenerative Conditions Research and Development Conference in San Francisco demonstrates the role of the investigational compound IRX4204 in alleviating cognitive decline in animal models of Alzheimer's disease (AD).

29 Oct 2012

Mouse model may provide clues on mechanism that links diabetes and aging to Alzheimer's

Growing evidence suggests that there may be a link between diabetes and Alzheimer's disease, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. In a new study published in Aging Cell, researchers at the Salk Institute for Biological Studies show, for the first time, that diabetes enhances the development of aging features that may underlie early pathological events in Alzheimer's.

29 Oct 2012

Study describes how Dbr1 gene halts toxic buildup of TDP-43-a protein

Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point to a potential new tactic for treating a variety of neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease)-a fatal disease for which there is no cure.

29 Oct 2012

Protein News and Research

Further Reading

TTP488 slows cognitive decline in patients with mild to moderate Alzheimer's

Positive results from Celldex’s CDX-1401 Phase 1 study on solid tumors

Scientists discover β2-syntrophin protein as new prognosis marker for prostate cancer

BioRx added to Zemaira distribution network

Scientists decode epigenetic programming of three virulent forms of acute lymphoblastic leukemia

Researchers zero in on process by which stem cells maintain proper undifferentiated state

Light-sensitive protein to study Parkinson's disease

Range of biopharma solutions from Malvern Instruments extended by distribution agreement with Affinity Biosensors

Researchers learn how E2-79 molecule destroys complexes that induce allergic responses

New therapy to treat rare form of cystic fibrosis works in unconventional way, scientists say

Researchers identify genes linked to serous endometrial cancer

Idea of nuclear reprogramming holds promise for repairing damaged tissue

Researchers use baker's yeast to identify new therapies for Lou Gehrig's disease

New HIV test for babies differs from conventional test, delivers diagnosis in less than an hour

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Researchers discover that bean commonly used in Chinese cuisine protects against sepsis

Resistin protein causes high levels of bad cholesterol

Study demonstrates role of IRX4204 in alleviating cognitive decline in animal models of AD

Mouse model may provide clues on mechanism that links diabetes and aging to Alzheimer's

Study describes how Dbr1 gene halts toxic buildup of TDP-43-a protein

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