Biochemistry News and Research

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Review highlights link between intestinal microbiota and colorectal cancer development

Recent evidence from animal models suggests a role for specific types of intestinal bacteria in the development of colorectal cancer (CRC).

9 Dec 2016

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. The technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.

9 Dec 2016

RNA modifications play significant role in function of nervous system

Researchers at the Institute of Molecular Biology and Johannes Gutenberg University Mainz have shown that a new way of regulating genes is vital for the activity of the nervous system.

8 Dec 2016

Biochemists uncover how potential diabetes drugs interact with LRH-1 protein

Imagine a key that opens a pin tumbler lock. A very similar key can also fit into the lock, but upside down in comparison to the first key.

6 Dec 2016

Researchers develop new microfluidic device to study brain inflammation

The blood-brain barrier is a network of specialized cells that surrounds the arteries and veins within the brain. It forms a unique gateway that both provides brain cells with the nutrients they require and protects them from potentially harmful compounds.

6 Dec 2016

UMass researchers develop new class of photodynamic molecules for treating deep-tissue tumors

UMass Medical School scientist Gang Han, PhD, and his team have designed a new class of molecules used in photodynamic therapy that are able to direct lamp light deep into tissue to kill cancer tumors.

5 Dec 2016

Research unlocks potential new therapies for inflammatory diseases

Macrophages are frontline cells in our immune system. They detect microbial invaders and also tissue injury and then mount an appropriate response needed to clear the infection and repair the damaged tissue.

5 Dec 2016

Study suggests new approach to treat white blood cells of sepsis patients

New research findings published in the Journal of Leukocyte Biology, suggest that treating the white blood cells of sepsis patients with antibodies that block programmed cell death-1 (PD-1) and programmed cell death ligand (PD-L1) molecules may restore their function and ultimately their ability to eradicate deadly bacteria.

1 Dec 2016

NSF awards grant to advance new diagnostic test for fatal gastrointestinal disease in pre-term infants

The National Science Foundation has chosen an LSU Health New Orleans team that developed a test for the early detection of a potentially life-threatening gastrointestinal disease affecting pre-term, low birthweight babies to receive expert guidance to move the technology forward.

1 Dec 2016

Duke researchers modify popular drug-delivery technology to evade immune responses

Biomedical engineers at Duke University have reconfigured a popular drug-delivery technology to evade immune responses that have halted some clinical trials.

1 Dec 2016

Type 2 diabetes drug may someday help combat breast and ovarian cancers

A drug used now to treat Type 2 diabetes may someday help beat breast and ovarian cancers, but not until researchers decode the complex interactions that in some cases help promote tumors, according to Rice University scientists.

30 Nov 2016

Biomedical scientist develops new way to create micro muscles for testing muscle efficiency

A biomedical research scientist is taking the lead in the creation of muscle cells and micro muscles to test muscle efficiency in the laboratory - and he is able to carry out this new and innovative work thanks to the support he has received to get him back into science after a career break.

30 Nov 2016

Mildly elevated body iron contributes to prevalence and incidence of type 2 diabetes

Even mildly elevated body iron contributes to the prevalence and incidence of type 2 diabetes, according to research from the University of Eastern Finland.

30 Nov 2016

Scientists create comprehensive computational metabolic models for different gut microbes

Hundreds of different bacterial species live in the human gut, helping us to digest our food. The metabolic processes of these bacteria are not only tremendously important to our health -- they are also tremendously complex.

29 Nov 2016

TUM scientists uncover molecular mechanisms of inhibitors that can selectively thwart immunoproteasome

The immunoproteasome dismantles proteins and the resulting fragments are displayed on the surface of cells. This helps the immune system to recognize abnormal cells. However, in chronic inflammations and autoimmune diseases this “information channel” is overactive.

29 Nov 2016

Study explores link between feeding behavior and alcohol consumption

Laboratory rats will drink alcohol if it's available, and may even get a little tipsy, researchers report in a new study.

23 Nov 2016

Omega-3 fatty acids can stimulate activation of brown and beige adipose tissues, study finds

Omega-3 fatty acids are able to stimulate the activation of brown and beige adipose tissues, a discovery that would promote the development of new therapies for obesity and other metabolism diseases, according to a research study published in the journal Nature Communications under the supervision of Professor Francesc Villarroya, from the Department of Biochemistry and Molecular Biomedicine and the Biomedical Research Center Red-Fisiopatología de la Obesidad y Nutrición (CIBEROBN) of the Institute of Health Carlos III.

21 Nov 2016

Scientists capture DNA intermediates that reveal how cancer evolves

Scientists from Rice University, Baylor College of Medicine and other institutions are using synthetic biology to capture elusive, short-lived snippets of DNA that healthy cells produce on their way to becoming cancerous.

18 Nov 2016

Researchers create new Zika replicon system to find ways to combat virus

New research from The University of Texas Medical Branch in Galveston, in collaboration with Southwest University in Chongqing, China and the University of Leuven in Belgium, have developed a way to replicate the basic structure of the Zika virus, stripping it of the genes that make the virus infectious.

18 Nov 2016

Scientists map reorganization of genetic material in cells using 3-D imaging technique

Scientists have mapped the reorganization of genetic material that takes place when a stem cell matures into a nerve cell.

17 Nov 2016

Biochemistry News and Research

Review highlights link between intestinal microbiota and colorectal cancer development

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

RNA modifications play significant role in function of nervous system

Biochemists uncover how potential diabetes drugs interact with LRH-1 protein

Researchers develop new microfluidic device to study brain inflammation

UMass researchers develop new class of photodynamic molecules for treating deep-tissue tumors

Research unlocks potential new therapies for inflammatory diseases

Study suggests new approach to treat white blood cells of sepsis patients

NSF awards grant to advance new diagnostic test for fatal gastrointestinal disease in pre-term infants

Duke researchers modify popular drug-delivery technology to evade immune responses

Type 2 diabetes drug may someday help combat breast and ovarian cancers

Biomedical scientist develops new way to create micro muscles for testing muscle efficiency

Mildly elevated body iron contributes to prevalence and incidence of type 2 diabetes

Scientists create comprehensive computational metabolic models for different gut microbes

TUM scientists uncover molecular mechanisms of inhibitors that can selectively thwart immunoproteasome

Study explores link between feeding behavior and alcohol consumption

Omega-3 fatty acids can stimulate activation of brown and beige adipose tissues, study finds

Scientists capture DNA intermediates that reveal how cancer evolves

Researchers create new Zika replicon system to find ways to combat virus

Scientists map reorganization of genetic material in cells using 3-D imaging technique

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