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Study sheds light on how cells repair damaged DNA

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells.

22 Nov 2024

Advanced diagnostic kit developed for detecting highly pathogenic H5N1 avian influenza virus

The Diagnostics Development Hub (DxD Hub), a national platform hosted by the Agency for Science, Technology and Research (A*STAR), Singapore, in collaboration with the National Institute for Environmental Studies (NIES), Japan, and the A*STAR Bioinformatics Institute (A*STAR BII), has successfully developed Steadfast, an advanced diagnostic kit for detecting the highly pathogenic H5N1 Avian Influenza Virus (AIV).

22 Nov 2024

New microscopy technique enables 3D RNA analysis in intact mouse brains

Researchers at Karolinska Institutet and Karolinska University Hospital have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains.

22 Nov 2024

Researchers develop efficient approach for designing custom proteins

Protein design aims to create customized antibodies for therapies, biosensors for diagnostics, or enzymes for chemical reactions.

22 Nov 2024

ESGCT Conference Takeaways: A specialty laboratory perspective

Discover the latest innovations in cell and gene therapy via Cerba Research's highlights of ESGCT.

From Cerba Research 22 Nov 2024

Fermented kimchi may help combat obesity by regulating gut microbiota

Kimchi consumption significantly reduces body fat and enhances metabolic indicators in overweight individuals, highlighting its role in obesity management.

22 Nov 2024

Predicting mood episodes with sleep data: A breakthrough for mental health care

Researchers developed a machine-learning model that uses only sleep-wake patterns to predict mood episodes in patients with mood disorders, achieving high accuracy. This approach simplifies real-world mental health monitoring using data from wearables or smartphones.

21 Nov 2024

Ingestible capsule releases a burst of drugs directly into the walls of the GI tract

Inspired by the way that squids use jets to propel themselves through the ocean and shoot ink clouds, researchers from MIT and Novo Nordisk have developed an ingestible capsule that releases a burst of drugs directly into the wall of the stomach or other organs of the digestive tract.

21 Nov 2024

Breakthrough discovery could lead to novel malaria vaccines and therapies

Malaria, particularly in its severe forms, remains a global health and economic burden. It causes the deaths of more than 600,000 people every year – most of them African children under five.

21 Nov 2024

Rare genetic mutations in healthy women may be key to breast cancer origins

Researchers at the University of British Columbia (UBC), BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early genetic origins of breast cancer - cancer-like mutations appearing in the cells of healthy women.

21 Nov 2024

Study reveals new genetic explanation for dilated cardiomyopathy

A potentially life-changing heart condition, dilated cardiomyopathy, can be caused by the cumulative influence of hundreds or thousands of genes and not just by a single "aberrant" genetic variant, as was previously thought, finds a new study led by researchers at UCL (University College London), Imperial College London and the MRC Laboratory of Medical Sciences.

21 Nov 2024

EZH2 enzyme drives aggressive tumor growth in treatment-resistant prostate cancer

An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, according to a new study by scientists at Weill Cornell Medicine.

20 Nov 2024

USC researchers receive $6 million to advance dry AMD treatment

The California Institute for Regenerative Medicine (CIRM), the state's stem cell agency, has awarded a two-year, $6 million grant to a team at the USC Dr. Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics and the USC Roski Eye Institute advancing a new treatment for one of the leading causes of blindness in older adults.

20 Nov 2024

Cigarette smoke can induce disordered oropharyngeal microbiota that aggravates flu severity

New research has shown that cigarette smoke can induce disordered oropharyngeal microbiota that aggravates the severity of influenza A virus infection.

20 Nov 2024

Squid-inspired technology could replace needles for medications and vaccines

The MiDe systems, inspired by squid propulsion, demonstrate effective needle-free drug delivery in the gastrointestinal tract, rivaling traditional methods.

20 Nov 2024

Researchers unlock cell density as a tool for building synthetic tissues

Genes aren't the sole driver instructing cells to build multicellular structures, tissues, and organs. In a new paper published in Nature Communications, USC Stem Cell scientist Leonardo Morsut and Caltech computational biologist Matt Thomson characterize the influence of another important developmental driver: cell density, or how loosely or tightly cells are packed into a given space.

20 Nov 2024

Using earpiece microphones to spot early signs of Alzheimer's

Alzheimer's disease affects more than 50 million people worldwide, often devastating both the individuals who have it and their families and loved ones.

20 Nov 2024

Barcoding small extracellular vesicles with new CRISPR-based system

Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology.

20 Nov 2024

Study uncovers diversity of cancer-associated fibroblasts in skin cancer

A study at MedUni Vienna's Department of Dermatology provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment.

19 Nov 2024

New CAR T-cell therapy shows promise against aggressive HER2+ breast cancer

One-third of HER2-positive (HER2+) tumors express the P95HER2 protein, which associates with an aggressive form of breast cancer with a poorer prognosis. Investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Growth Factors Group, in collaboration with researchers of the Cancer Research Program of Hospital del Mar Research Institute (HMRI), Barcelona, have developed novel chimeric antigen receptor (CAR) T-cell therapy that can produce a potent antitumor response against p95HER2-expressing cells.

19 Nov 2024