Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease, according to a study published in the October 12 issue of Neurology, the scientific journal of the American Academy of Neurology.

11 Oct 2004

High blood pressure can effect many life activities, including sex

Despite its seeming invisibility, high blood pressure is dangerous, even deadly. Its effects can linger throughout many life activities, including sex.

29 Sep 2004

Research to halt the progress of chronic liver disease

A University of Queensland researcher is working to halt the progress of chronic liver disease, which affects a quarter of million Australians.

22 Sep 2004

Celacade shown to reduce risk of death and hospitalization in patients with advanced chronic heart failure

Vasogen has announced that comprehensive results from the Company's phase II trial of Celacade (immune modulation therapy) in advanced chronic heart failure patients were published in the September 15 issue of the Journal of the American College of Cardiology (JACC).

16 Sep 2004

HHS enhances Medicare drug card program to help seniors

Health and Human Services Secretary Tommy G. Thompson today announced new measures to help seniors get the lowest price possible for their medicines by allowing them -- for the first time -- to compare prices for similar drugs used to treat common diseases such as high cholesterol or blood pressure.

15 Sep 2004

Ramipril reduces rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent

Ramipril, a high blood pressure and heart failure drug, can reduce the rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent in people at high risk for heart attack or stroke, according to a study reported in Circulation: Journal of the American Heart Association.

7 Sep 2004

Angina drug nifedipine safe for long-term use

Calcium antagonists such as nifedipine are used to relieve the symptoms of angina, but there have been doubts about their long-term safety. However, ACTION--A Coronary disease Trial Investigating Outcome with Nifedipine GITS--provides new information on the drug's long-term use. GITS (gastrointestinal therapeutic system) modifies the release of the drug to provide stable long-term concentrations of nifedipine in blood.

30 Aug 2004

Surgery for angina in the elderly provides long-term mortality

Elderly people who undergo surgery or angioplasty to treat chest pain fare just as well long-term as those treated with medication, researchers report in Circulation: Journal of the American Heart Association.

30 Aug 2004

New guidelines urge early and long-term treatment with Aldosterone blockade therapy

Patients who have had a recent heart attack with ST-elevation (ST-Elevation Myocardial Infarction, or STEMI), complicated by heart failure should be treated with aldosterone blockers according to new guidelines issued recently by the American College of Cardiology (ACC) and the American Heart Association (AHA).

17 Aug 2004

Important for physicians to identify patients at risk for hyperkalemia and implement corresponding measures when using ACE inhibitors

Some patients with hypertension or other cardiovascular diseases should be closely monitored in order to maintain safe potassium levels in the body when prescribed certain medications, counsels a nephrologist at UT Southwestern Medical Center at Dallas.

11 Aug 2004

Third of heart failure patients face increased risk of death because they do not receive an angiotensin-converting enzyme (ACE) inhibitor

Overwhelming evidence accumulated during almost 20 years of clinical experience has established the benefits of this drug, which blocks the harmful effects of angiotensin, a substance that causes blood vessels to narrow, said the study authors.

3 Aug 2004

Hormone that is important in the control of blood pressure may also inhibit the growth of lung cancer cells

Their studies found that angiotensin-(1-7) significantly slows the growth of three different types of human lung cancer cells in the laboratory. "Our experiments provide the first evidence that angiotensin-(1-7) inhibits the proliferation of human lung cancer cells," they said.

2 Aug 2004

Trial sparks debate over treatment of diabetic hypertensives

A major new international study published in the Journal of Hypertension has challenged traditional thinking by revealing that the thiazide-like diuretic indapamide SR (Natrilix SR) has equivalent efficacy to enalapril in reducing microalbuminuria (MA) in patients with type 2 diabetes.

22 Jul 2004

New guidelines for treating heart attacks

If your chest pain worsens and lasts more than five minutes, especially if you’re short of breath, feel weak, nauseated or lightheaded, call 9-1-1—you could be having a heart attack.

8 Jul 2004

Exercise found to be equally effective as diuretics in preventing high blood pressure and an enlarged heart

Only recently was a type of diuretic known as thiazides been found to be superior to angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists (calcium channel blockers) in preventing one or more major types of cardiovascular disease.

30 Jun 2004

Valsartan may reduce cardiac illness and death

Results of a study in this week's issue of THE LANCET provide further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk. The study also emphasises the importance of early blood-pressure lowering after the start of treatment to reduce the risk of cardiovascular events such as heart attack and stroke.

17 Jun 2004

Further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk

Results of a study in this week’s issue of THE LANCET provide further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk. The study also emphasises the importance of early blood-pressure lowering after the start of treatment to reduce the risk of cardiovascular events such as heart attack and stroke.

17 Jun 2004

Heart attack patients are discharged without evidenced-based, guideline recommended, life-prolonging therapies

Heart attack care is more likely to match recommended guidelines when health care providers use standardized forms and other reminders, and institutional systems reinforce goals for treatment and patient lifestyles, according to a new study in the June 16, 2004 issue of the Journal of the American College of Cardiology.

16 Jun 2004

65 percent of America’s adults are overweight and 31 percent of adults are obese and at risk for chronic diseases

Government and private sector health experts now estimate that 65 percent of America’s adults are overweight and 31 percent of adults are obese and at risk for chronic diseases such as diabetes and hypertension. The link between obesity and hypertension is well known, but the exact nature of the association between the two disorders remains unclear.

11 Jun 2004

Prescribing ACE inhibitors to in-patients is important, but outpatients need ongoing support

Use of angiotensin-converting enzyme (ACE) inhibitors by heart failure patients drops sharply within a month after they go home from the hospital and then continues to decline, according to a new study in the June 2, 2004 issue of the Journal of the American College of Cardiology.

2 Jun 2004