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Vitamin E significantly improves liver health in MASH patients, new study finds

A 96-week clinical trial found that 300 mg of Vitamin E significantly improved liver histology and reduced inflammation in patients with MASH, with no major safety concerns reported.

19 Feb 2025

Researchers develop mouse model to study neutrophilic asthma

A better understanding of inflammation and lung immunity over the past two decades has led to new, innovative treatments for asthma, including biologic therapies.

18 Feb 2025

Olpasiran significantly lowers "bad cholesterol" linked to cardiovascular risk

The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of cardiovascular events, according to results from an analysis by a Mount Sinai researcher of a phase 2 trial.

13 Feb 2025

Gut microbes influence how well cancer patients respond to immunotherapy

Researchers discovered that gut microbiota-derived hexa-acylated LPS enhances the effectiveness of anti-PD-1 cancer immunotherapy, while penta-acylated LPS may suppress immune responses.

11 Feb 2025

E64FC26 inhibits inflammation and joint destruction in rheumatoid arthritis models

Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the endoplasmic reticulum.

10 Feb 2025

COVID-19 speeds up artery plaque growth, raising heart disease risk

COVID-19 accelerates the progression of atherosclerotic plaques, increasing coronary inflammation and the risk of high-risk plaques, even in non-hospitalized individuals.

5 Feb 2025

AI predicts effective treatment for rare disease using existing medications

After combing through 4,000 existing medications, an artificial intelligence tool helped uncover one that saved the life of a patient with idiopathic multicentric Castleman's disease (iMCD).

5 Feb 2025

Study links low levels of PM2.5 exposure to liver damage

Researchers examine the liver toxicity of low levels of PM2.5 exposure.

5 Feb 2025

How exercise affects appetite in obese men

Researchers examine how appetite-associated factors impact appetite perception in obese males.

3 Feb 2025

Researchers develop T cell growth method that enhances cancer-fighting ability in melanoma model

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

31 Jan 2025

Gut-derived sugars: A potential game-changer for weight management and diabetes

Gut bacteria-produced exopolysaccharides (EPS) help regulate metabolism by modulating gut microbiota, promoting SCFA production, and improving glucose homeostasis. S. salivarius, a key EPS producer, shows potential for obesity and diabetes intervention.

30 Jan 2025

New insights into mechanisms of mucosal mast cells in food allergies

Food allergy, or the aggressive immune system reaction following the consumption of a certain food or food ingredient, typically involves immunoglobulin E (IgE) antibodies and can be potentially life-threatening

29 Jan 2025

Study uncovers distinct blood protein signature in children with Long COVID

Distinct protein profiles linked to inflammation and angiogenesis found in children with Long COVID, paving the way for improved diagnostics and therapies.

28 Jan 2025

Study reveals sex-specific differences in microglial response to CSF1R inhibition

Researchers investigate the sex-dependent microglial response to a colony-stimulating factor 1 receptor (CSF1R) inhibitor.

24 Jan 2025

Researchers investigate a new combination therapy against cancer

A research team at the Medical University of Vienna led by Maria Sibilia has investigated a new combination therapy against cancer.

23 Jan 2025

AGA releases updated guidelines on hepatitis B reactivation in patients on immunosuppressive drugs

The American Gastroenterological Association (AGA) has unveiled an updated clinical practice guideline in Gastroenterology addressing the prevention and management of hepatitis B virus reactivation (HBVr) in patients on immunosuppressive drugs.

23 Jan 2025

Novel method to fight cancer uses ultrasound-guided microbubbles

A new paper by a team of Concordia researchers from the departments of Biology and Physics proposes a novel method of fighting cancer tumours that uses ultrasound-guided microbubbles - a technology already widely used in medical imaging and drug delivery.

16 Jan 2025