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Artificial stomach provides deeper understanding of how physical forces influence food digestion

In efforts to fight obesity and enhance drug absorption, scientists have extensively studied how gastric juices in the stomach break down ingested food and other substances. However, less is known about how the complex flow patterns and mechanical stresses produced in the stomach contribute to digestion.

3 Aug 2021

'Good cholesterol' protects the liver from inflammation and injury, study shows

The body's so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury.

22 Jul 2021

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

Three-dimensional organoid structures grown in the lab allow deeper, almost in situ investigation of a biological system, without the use of living animals. In a paper recently uploaded to the preprint server bioRxiv*, organoids generated from human specimens are utilized to investigate the way in which SARS-CoV-2 interacts with the numerous cells of the intestinal epithelium, finding great heterogeneity in the susceptibility of the organoids and the cells within to infection.

21 Jul 2021

IgA deficiency results in substantial intestinal inflammation, study reveals

While researchers have known for years that immunoglobulin A (IgA) is important for gut health, it has remained unclear exactly what role it plays in preventing infection and disease. But now, researchers from Japan have found that eliminating IgA disrupts the balance of the intestinal ecosystem, making it susceptible to disease.

20 Jul 2021

Researchers discover major metabolite involved in regulating intestinal bacteria

Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered that acetate, a major metabolite produced by some intestinal bacteria, is involved in regulating other intestinal bacteria.

19 Jul 2021

Irritable bowel syndrome is linked to bacterial biofilms in the gut

One in six women and one in twelve men in Austria suffers from some form of IBS - therefore around one million people in all. Using currently available techniques, it is only possible to diagnose IBS by a process of elimination.

21 Jun 2021

Study reveals how high fat diets can cause intestinal and colon cancer

For decades, physicians and dieticians have urged people to limit their intake of high fat foods, citing links to poor health outcomes and some of the leading causes of death in the U.S., such as diabetes, heart disease and cancer.

9 Jun 2021

How mass screening efforts have helped identify more cases of celiac disease in children

A new mass screening program of school-aged children in Italy found that the overall prevalence of celiac disease has almost doubled in the past 25 years.

4 Jun 2021

New microbial genes responsible for bile acid conversion is a major step forward for gut health

As the owner of a human body, you're carrying trillions of microbes with you everywhere you go. These microscopic organisms aren't just hitching a ride; many of them perform essential chemical reactions that regulate everything from our digestion to our immune system to our moods.

27 May 2021

Study shows how rare but serious post-COVID-19 complication develops in children, adolescents

A multidisciplinary team from MassGeneral Hospital for Children (MGHfC), Brigham and Women's Hospital and other institutions have identified the mechanism of how an extremely rare but serious post-COVID-19 complication develops in children and adolescents.

26 May 2021

Risk factors for rare COVID-19 complications in children (MIS-C)

While the earlier waves of COVID-19 relatively spared children, some of the affected children have developed a systemic inflammatory condition, with occasionally fatal outcomes. Called multisystem inflammatory syndrome in children (MIS-C), its pathogenesis and risk factors are the subject of a new study on the medRxiv* preprint server.

21 May 2021

Owlstone Medical Launches Breath Testing for Digestive Health in Collaboration with Functional Gut Diagnostics and Functional Gut Clinic

Owlstone Medical today announced agreements with Functional Gut Clinic ("FGC") and Functional Gut Diagnostics (“FGD”).

From Owlstone Medical Ltd 18 May 2021

Is COVID-19 a new disease?

In a review recently published in The Lancet Respiratory Medicine journal by Osuchowski et al. (May 6th, 2021) the currently known pathophysiology of COVID-19 is laid out to describe the mechanistic features that make COVID-19 distinct from many conditions previously thought to be similar.

9 May 2021

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn's disease in a flagellin peptide-specific immunotherapy.

6 May 2021

SARS-CoV-2 study in human gut organoids

Most of the major life-threatening symptoms of COVID-19 disease are associated with the host's generation of an exacerbated pro-inflammatory immune response. Many studies have correlated the intensity of the immune response with the severity of disease.

3 May 2021

Small Intestine News and Research

Artificial stomach provides deeper understanding of how physical forces influence food digestion

'Good cholesterol' protects the liver from inflammation and injury, study shows

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

IgA deficiency results in substantial intestinal inflammation, study reveals

Researchers discover major metabolite involved in regulating intestinal bacteria

Irritable bowel syndrome is linked to bacterial biofilms in the gut

Study reveals how high fat diets can cause intestinal and colon cancer

How mass screening efforts have helped identify more cases of celiac disease in children

New microbial genes responsible for bile acid conversion is a major step forward for gut health

Study shows how rare but serious post-COVID-19 complication develops in children, adolescents

Risk factors for rare COVID-19 complications in children (MIS-C)

Owlstone Medical Launches Breath Testing for Digestive Health in Collaboration with Functional Gut Diagnostics and Functional Gut Clinic

Is COVID-19 a new disease?

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

SARS-CoV-2 study in human gut organoids

Some heart medications may facilitate SARS-CoV-2 infection through increasing ACE2 receptor levels

Study may provide a basis for oral insulin development using DNP peptides

Probiotic L. acidophilus can effectively treat intestinal inflammation, research shows

Study offers localized treatment direction for a cause of Crohn's disease

A novel approach to oral vaccination against Covid-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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