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Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Researchers in China have conducted a study showing that a carbohydrate found in the seaweed Ecklonia kurome blocks the activity of an enzyme that is essential for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

18 Jan 2021

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

A new study suggests that modified natural killer cells, which express a chimeric antigen receptor using S309 antibody, can bind to and inactivate SARS-CoV-2 spike protein in vitro.

18 Jan 2021

Angiopoietin-2 is a crucial determinant of COVID-19 prognosis, study finds

A team of scientists from the United States and Sweden has recently demonstrated that increased levels of a proinflammatory cytokine, angiopoietin-2, is responsible for hypercoagulation observed in severe COVID-19 patients.

18 Jan 2021

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

The potentially deadly COVID-19 has not affected animals with corresponding severity. To understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new study indicates that this may not be a faithful model of human lethal infection with SARS-CoV-2.

18 Jan 2021

Researchers produce first African lion in-vitro embryos after vitrification of immature oocytes

A team of scientists from the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) inGermany, Givskud Zoo - Zootopia in Denmark and the University of Milan in Italy succeeded in producing the very first African lionin-vitroembryos after the vitrification of immature oocytes.

18 Jan 2021

Research suggests St. John's Wort and Echinacea could protect against COVID-19

Researchers in Saudi Arabia have conducted a study demonstrating the antiviral effects of two medicinal herbs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

17 Jan 2021

Study reveals significant role of ADAMTS1 protein in uveal melanoma

Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.

15 Jan 2021

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

An encouraging new study describes a promising new therapeutic antibody that shows potent neutralizing activity against SARS-CoV-2, the causative agent of COVID-19.

15 Jan 2021

New cancer models mimic aspects of mechanical environment within the body

As cancer and tumor cells move inside the human body, they impart and are subject to mechanical forces.

15 Jan 2021

A snake venom enzyme shows anti-SARS-CoV-2 activity in vitro

A new study reports the virucidal and fusion-inhibiting attributes of snake venom against the COVID-19 agent SARS-CoV-2.

14 Jan 2021

EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages.

14 Jan 2021

Influenza drug enisamium a potential COVID-19 treatment

Researchers in Europe and the United States have demonstrated the potential of the influenza drug enisamium as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

13 Jan 2021

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Now, a new preprint research paper published on the bioRxiv server shows how closely the antibodies formed in exposed humans resemble the germline antibody molecules. This could lead to the development of novel therapeutics to counter the pandemic.

12 Jan 2021

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Researchers in the United States have shown that extracts of an aromatic herb called Artemisia annua inhibit the replication of severe acute respiratory coronavirus (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

11 Jan 2021

Researchers develop a novel, patient-derived model of ulcerative colitis

As reported in Nature Communications, researchers from Cleveland Clinic's Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease.

11 Jan 2021

Researchers demonstrate SARS-CoV-2 infection in human lung bronchioalveolar tissue model

Development of an in vitro human-derived tissue model for studying virus infection and disease progression in the alveolar cells of the lungs responsible for oxygen and carbon dioxide exchange with the blood might enable the study of possible therapies for acute respiratory distress syndrome (ARDS) triggered by SARS-CoV-2.

11 Jan 2021

Vimentin could be a major co-factor that aids SARS-CoV-2 infection

A recent study has found that extracellular vimentin can bind to SARS-CoV-2 spike protein in vitro, and antibodies against vimentin can decrease virus infectivity by up to 80%. This suggests vimentin could aid the virus’s binding to host cells and help in infection.

11 Jan 2021

Could Ivermectin be an effective antiviral against SARS-CoV-2?

A double-blind, randomized, placebo-controlled clinical trial has recently demonstrated that Ivermectin, an anti-parasitic drug, can reduce in-hospital mortality rate of COVID-19 patients.

11 Jan 2021

Synthetic lung organoids provide high-throughput platform to identify new cellular targets of SARS-CoV-2

An interesting new study published on the bioRxiv preprint server describes a new platform that allows a high-throughput workflow to generate matched human lung buds in the tens of thousands. This allows researchers to study SARS-CoV-2 infection and therapeutics in lung tissue that mirrors the key aspects of human lung development.

10 Jan 2021

in vitro News and Research

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

Angiopoietin-2 is a crucial determinant of COVID-19 prognosis, study finds

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

Researchers produce first African lion in-vitro embryos after vitrification of immature oocytes

Research suggests St. John's Wort and Echinacea could protect against COVID-19

Study reveals significant role of ADAMTS1 protein in uveal melanoma

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

New cancer models mimic aspects of mechanical environment within the body

A snake venom enzyme shows anti-SARS-CoV-2 activity in vitro

EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests

Influenza drug enisamium a potential COVID-19 treatment

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Researchers develop a novel, patient-derived model of ulcerative colitis

Researchers demonstrate SARS-CoV-2 infection in human lung bronchioalveolar tissue model

Vimentin could be a major co-factor that aids SARS-CoV-2 infection

Could Ivermectin be an effective antiviral against SARS-CoV-2?

Synthetic lung organoids provide high-throughput platform to identify new cellular targets of SARS-CoV-2

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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