Genetic Engineering News and Research

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In vivo genome editing restores hemostasis in mouse model of blood clotting disorder

Using an innovative gene therapy technique called genome editing that hones in on the precise location of mutated DNA, scientists have treated the blood clotting disorder hemophilia in mice.

27 Jun 2011

Diabetic patients can benefit from basal insulin analogs

Basal insulin analogs have revolutionized diabetes care, and especially the treatment of type 2 diabetes, enabling patients to achieve better control of blood glucose levels while reducing hypoglycemic episodes.

27 Jun 2011

Hunger hormone likely to cause stress-linked complex eating behaviors

We are one step closer to deciphering why some stressed people indulge in chocolate, mashed potatoes, ice cream and other high-calorie, high-fat comfort foods. UT Southwestern Medical Center-led findings, in a mouse study, suggest that ghrelin - the so-called "hunger hormone" - is involved in triggering this reaction to high stress situations.

24 Jun 2011

Scientists discover sleep switch in fruit fly's brain

Rather than count sheep, drink warm milk or listen to soothing music, many insomniacs probably wish for a switch they could flick to put themselves to sleep.

24 Jun 2011

Scientists observe key aspects of how memory circuits in the brain refine themselves

Scientists at the University of Michigan Health System have for the first time demonstrated how memory circuits in the brain refine themselves in a living organism through two distinct types of competition between cells.

23 Jun 2011

Targeting activity of PKD1 may be beneficial for treatment of polycystic kidney, liver disease

A single gene is central in the development of several forms of polycystic kidney and liver disease, Yale School of Medicine researchers report in the June 19 issue of Nature Genetics.

20 Jun 2011

WHO special issue addresses economic burden of dengue in the Americas, Africa and Asia

The ten studies in this special issue document the substantial and growing burden of dengue in the Americas, Africa and Asia, and the burden of a chikungunya outbreak in India.

18 Jun 2011

New Australian drug shows positive response in patients with multiple myeloma blood cancer

Australian monoclonal antibody company, Immune System Therapeutics Limited (IST), today announced it would double patient recruitment in its Phase II trial for a breakthrough antibody treatment for terminal blood cancer.

16 Jun 2011

Adaptimmune melanoma trial opening

Adaptimmune announced today that it has opened a Phase I/II, two cohort, open label clinical trial in metastatic melanoma at Washington University, St. Louis, Missouri.

16 Jun 2011

Platelet Derived Growth Factor Receptor-beta plays key role in onset of obesity

A new study from Mount Sinai School of Medicine has found that a cellular signaling pathway governs the differentiation of cells into fat tissue or smooth muscle, which lines the vascular system. Engaging this signaling pathway and its capacity to govern cell differentiation has important implications in preventing obesity and cardiovascular disease.

16 Jun 2011

UC Davis, Jackson Laboratory and NCI partner for human clinical trials on cancer

About nine out of 10 new cancer drugs successfully clear preclinical development hurdles, but then they fail in human clinical testing. A new partnership facilitated by SAIC-Frederick Inc. aims to help change that outcome.

13 Jun 2011

Synaptophysin controls replacement of vesicles

A University of Wisconsin-Madison research team has solved a 25-year mystery that may lead to better treatments for people with learning deficits and mental retardation.

9 Jun 2011

Research in progress for novel protein kinase inhibitors: GEN

Biotech scientists are working on novel protein kinase inhibitors that are targeting a host of conditions ranging from atherosclerosis to neurodegenerative diseases, reports Genetic Engineering & Biotechnology News.

4 Jun 2011

Preclinical study: Combination therapy of SPX-106 and D-tagatose reduces triglycerides and cholesterol

Spherix Incorporated, an innovator in biotechnology for therapy in diabetes, metabolic syndrome and atherosclerosis, and providers of technical and regulatory consulting services to food, supplement, biotechnology and pharmaceutical companies, today announced that its drug candidate, SPX-106, achieved statistically significant reductions in triglycerides and cholesterol when administered in combination with D-tagatose for nine weeks to genetically engineered mice prone to dyslipidemia.

3 Jun 2011

Adaptimmune announces opening of Phase I/II clinical trial in multiple myeloma

Adaptimmune announced that it has opened a Phase I/II, dual site, two-cohort, open-label clinical trial in multiple myeloma at the University of Maryland and the University of Pennsylvania testing its enhanced T cell receptor T cell therapy.

1 Jun 2011

Exposure to pesticides near any workplace increases risk of Parkinson's disease

In April 2009, researchers at UCLA announced they had discovered a link between Parkinson's disease and two chemicals commonly sprayed on crops to fight pests.

27 May 2011

'Survival protein' protects brain against effects of stroke

Johns Hopkins scientists say that a newly discovered "survival protein" protects the brain against the effects of stroke in rodent brain tissue by interfering with a particular kind of cell death that's also implicated in complications from diabetes and heart attack.

24 May 2011

Discovery of possible new strategy for treating neurologic disorders

23 May 2011

Salk researchers successfully edit diseased gene in patient-specific induced pluripotent stem cells

In principle, genetic engineering is simple, but in practice, replacing a faulty gene with a healthy copy is anything but. Using mutated versions of the lamin A gene as an example to demonstrate the versatility of their virus-based approach, researchers at the Salk Institute for Biological Studies successfully edited a diseased gene in patient-specific induced pluripotent stem cells as well as adult stem cells.

21 May 2011

Walter and Eliza Hall Institute researcher selected Fellow of the Royal Society

Internationally recognised malaria researcher Professor Alan Cowman from the Walter and Eliza Hall Institute in Melbourne, Australia, has been elected a Fellow of the Royal Society, the UK's peak academy promoting excellence in science.

21 May 2011

Genetic Engineering News and Research

In vivo genome editing restores hemostasis in mouse model of blood clotting disorder

Diabetic patients can benefit from basal insulin analogs

Hunger hormone likely to cause stress-linked complex eating behaviors

Scientists discover sleep switch in fruit fly's brain

Scientists observe key aspects of how memory circuits in the brain refine themselves

Targeting activity of PKD1 may be beneficial for treatment of polycystic kidney, liver disease

WHO special issue addresses economic burden of dengue in the Americas, Africa and Asia

New Australian drug shows positive response in patients with multiple myeloma blood cancer

Adaptimmune melanoma trial opening

Platelet Derived Growth Factor Receptor-beta plays key role in onset of obesity

UC Davis, Jackson Laboratory and NCI partner for human clinical trials on cancer

Synaptophysin controls replacement of vesicles

Research in progress for novel protein kinase inhibitors: GEN

Preclinical study: Combination therapy of SPX-106 and D-tagatose reduces triglycerides and cholesterol

Adaptimmune announces opening of Phase I/II clinical trial in multiple myeloma

Exposure to pesticides near any workplace increases risk of Parkinson's disease

'Survival protein' protects brain against effects of stroke

Discovery of possible new strategy for treating neurologic disorders

Salk researchers successfully edit diseased gene in patient-specific induced pluripotent stem cells

Walter and Eliza Hall Institute researcher selected Fellow of the Royal Society

eBook: Using iPSCs models for human disease research and drug discovery eBook

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