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Experimental vaccine elicits antibodies that can protect against Ebola virus infection

Researchers at the National Institutes of Health (NIH) and Oregon Health & Science University (OHSU) have found that an experimental vaccine elicits antibodies that can protect nonhuman primates from Ebola virus infection.

16 Jan 2013

Greater selectivity in GI bleeding prophylaxis needed

Researchers have developed a risk-scoring system to identify noncritically ill hospital patients most likely to benefit from prophylactic acid-suppressive medication.

14 Jan 2013

Mirena coil intrauterine device a better treatment for heavy menstrual periods

The hormone-releasing Mirena coil intrauterine device (IUD) is a better treatment for heavy menstrual periods than other conventional medical approaches, according to results of a major clinical trial led by scientists from the Universities of Nottingham and Birmingham.

11 Jan 2013

Researchers uncover genetic causes of von Willebrand disease

In 2006, the lab of Dr. David Ginsburg at the Life Sciences Institute put a call out for siblings attending the University of Michigan to donate blood for a study of blood-clotting disorders.

10 Jan 2013

Mussels may provide highly adhesive wound closure and more effective healing from surgery

Mussels can be a mouthwatering meal, but the chemistry that lets mussels stick to underwater surfaces may also provide a highly adhesive wound closure and more effective healing from surgery.

10 Jan 2013

New scoring system can help clinicians better identify non-ICU patients at risk for GI bleeding

Critically ill patients in hospital intensive care units (ICUs) are routinely prescribed acid-suppressive medications to reduce their risk of developing stress ulcers and gastrointestinal bleeding, both of which can result from being in a stressful environment and from being intubated. Over the years, this routine practice has often been extended to patients outside the ICU, despite a lack of evidence that this population is at significant risk of these complications.

9 Jan 2013

Periodontal disease may predispose men to impotence

Men in their thirties with chronic gum disease are at significantly increased risk for erectile dysfunction, suggests a study by Turkish researchers.

7 Jan 2013

Merck’s resubmission of the NDA for suggammadex sodium injection accepted for review by the FDA

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the resubmission of the New Drug Application (NDA) for sugammadex sodium injection has been accepted for review by the U.S. Food and Drug Administration (FDA). Merck expects the FDA’s review to be completed in the first half of 2013.

7 Jan 2013

Biogen Idec files rFIXFc BLA with FDA for treatment of hemophilia B

Today Biogen Idec announced the company recently submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for the marketing approval of recombinant factor IX Fc fusion protein (rFIXFc) for the treatment of hemophilia B.

7 Jan 2013

PharmaIN receives FDA orphan-drug designation for terlipressin to treat ascites

PharmaIN Corporation and LAT Pharma LLC today announced that the US Food and Drug Administration (FDA) has granted their request for orphan-drug designation for terlipressin for the treatment of ascites due to all etiologies except for cancer.

7 Jan 2013

Supplementary grading system best for cerebellar vascular malformations

The Spetzler–Martin grading system is a poor predictor of outcomes of patients with cerebellar arteriovenous malformations, research indicates.

4 Jan 2013

Raising transfusion threshold improves acute upper GI bleeding outcomes

Outcomes among patients with acute upper gastrointestinal bleeding can be improved by employing a restrictive transfusion strategy that raises the threshold for the transfusion of red cells, the results of a Spanish study indicate.

4 Jan 2013

Study questions need for routine repeated CT scans in patients with mild head trauma

When initial computed tomography (CT) scans show bleeding within the brain after mild head injury, decisions about repeated CT scans should be based on the patient's neurological condition, according to a report in the January issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

4 Jan 2013

ParoChip can allow dentists to quickly detect and analyze periodontitis pathogens

Bleeding gums during tooth brushing or when biting into an apple could be an indication of periodontitis, an inflammatory disease of the tissues that surround and support the teeth. Bacterial plaque attacks the bone, meaning teeth can loosen over time and in the worst case even fall out, as they are left without a solid foundation to hold them in place.

4 Jan 2013

Bristol-Myers Squibb, Pfizer receive FDA approval for ELIQUIS to reduce risk of stroke and SE

Bristol-Myers Squibb Company and Pfizer Inc. announced that the U.S. Food and Drug Administration (FDA) approved ELIQUIS (apixaban) to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

2 Jan 2013

Fibrinogen could bypass intraoperative transfusion needs

Giving fibrinogen as first-line treatment for intraoperative bleeding could reduce the need for blood transfusion, shows a small randomized controlled trial.

2 Jan 2013

Thromboprophylaxis does more harm than good in head and neck surgery

Patients undergoing oncologic head and neck surgery do not benefit from thromboprophylaxis, report researchers.

2 Jan 2013

Oral Eliquis receives FDA approval for treatment of clots in non-valvular atrial fibrillation patients

The U.S. Food and Drug Administration today approved the anti-clotting drug Eliquis (apixaban), an oral tablet used to reduce the risk of stroke and dangerous blood clots (systemic embolism) in patients with atrial fibrillation that is not caused by a heart valve problem.

29 Dec 2012

Concern over transfusions in myocardial infarction patients

A meta-analysis highlights the consistent observational finding that patients with myocardial infarction who receive blood transfusions are at high risk for dying.

28 Dec 2012

Blood transfusion for patients with myocardial infarction associated with increased all-cause mortality

A meta-analysis of 10 studies suggests that receipt of a blood transfusion among patients with myocardial infarction (heart attack) was associated with increased all-cause mortality compared with not receiving a blood transfusion during heart attack, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.

25 Dec 2012

Bleeding News and Research

Experimental vaccine elicits antibodies that can protect against Ebola virus infection

Greater selectivity in GI bleeding prophylaxis needed

Mirena coil intrauterine device a better treatment for heavy menstrual periods

Researchers uncover genetic causes of von Willebrand disease

Mussels may provide highly adhesive wound closure and more effective healing from surgery

New scoring system can help clinicians better identify non-ICU patients at risk for GI bleeding

Periodontal disease may predispose men to impotence

Merck’s resubmission of the NDA for suggammadex sodium injection accepted for review by the FDA

Biogen Idec files rFIXFc BLA with FDA for treatment of hemophilia B

PharmaIN receives FDA orphan-drug designation for terlipressin to treat ascites

Supplementary grading system best for cerebellar vascular malformations

Raising transfusion threshold improves acute upper GI bleeding outcomes

Study questions need for routine repeated CT scans in patients with mild head trauma

ParoChip can allow dentists to quickly detect and analyze periodontitis pathogens

Bristol-Myers Squibb, Pfizer receive FDA approval for ELIQUIS to reduce risk of stroke and SE

Fibrinogen could bypass intraoperative transfusion needs

Thromboprophylaxis does more harm than good in head and neck surgery

Oral Eliquis receives FDA approval for treatment of clots in non-valvular atrial fibrillation patients

Concern over transfusions in myocardial infarction patients

Blood transfusion for patients with myocardial infarction associated with increased all-cause mortality

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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