Laboratory News and Research

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High blood glucose levels early in pregnancy deprive the embryo of oxygen

The babies of women with diabetes are two to five times more likely to develop birth defects than offspring of women without the disease.

4 Oct 2005

First recordings from medial mammillary body cells in awake animals

It's often said that the key to Bill Bradley's basketball success was summed up in the title of the 1965 book by John McPhee, "A sense of where you are." Bradley always seemed to know where all nine other players were, where Bradley himself was in relation to the basket – and where the open spot was to be found for his stylized jump shot.

4 Oct 2005

Johns Hopkins awarded $12 million to study how stem cell therapies can be used to treat hearts damaged by heart attack

Heart specialists at Johns Hopkins Heart Institute have been awarded more than $12 million from the National Heart, Lung, and Blood Institute (NHLBI) to study how stem cell therapies can be used to treat hearts damaged by heart attack or heart failure.

4 Oct 2005

First conference focusing on assessing and improving the organizational environment and culture of academic medical centers

Rigorous course work, state of the art laboratories, relevant textbooks and demanding clinical rotations produce technically competent physicians. But surveys say that in addition to highly qualified care givers, we want doctors who are compassionate and know how to communicate well when caring for us and our loved ones

4 Oct 2005

Use of the antibiotic amoxicillin during infancy appears to be linked to tooth enamel defects in permanent teeth

Dental fluorosis, a result of exposure to excessive fluoride during enamel formation, is one of the most common developmental enamel defects, according to background information in the article.

4 Oct 2005

Discovery has implications for research on restoring mobility to people who have lost motor functions due to spinal cord injury

Yale School of Medicine researchers report in Science this week genetic evidence for the hypothesis that myelination, or formation of a protective sheath around a nerve fiber, consolidates neural circuitry by suppressing plasticity in the mature brain.

3 Oct 2005

Research on cartilage erosion and bone abnormalities

While characteristic of osteoarthritis (OA), a degenerative joint disease that affects some 20 million Americans, cartilage erosion and bone abnormalities are also associated with many rare hereditary conditions.

3 Oct 2005

Potential biomarker that could be used to predict who might develop hepatic fibrosis

Two new studies on Hepatitis C (HCV) patients who underwent liver transplants examined a potential biomarker that could be used to predict who might develop hepatic fibrosis, a formation of scar-like tissue that can lead to cirrhosis.

3 Oct 2005

Lack of oxygen in body tissues creates a defect of red blood cells that further exacerbates the condition by constricting blood vessels in the lung

What's more, the team demonstrated through studies in people and animals that inhalation of a 'souped up' form of nitric oxide, which targets red blood cells, reverses the blood abnormality to restore normal lung pressure.

3 Oct 2005

Compounds secreted by frog skin are potent blockers of HIV infection

The findings could lead to topical treatments for preventing HIV transmission, and they reinforce the value of preserving the Earth's biodiversity.

3 Oct 2005

Potential beneficial effect of copper orotate

As one of the services for patients with Alzheimer's disease, the Department of Psychiatry at the Saarland University Medical Center offers participation in a clinical phase II trial. This clinical trial aims to elucidate a potential beneficial effect of copper orotate (an organic copper salt), which is given together with a standard cholinesterase inhibitor.

3 Oct 2005

Sharper picture than previously available of major depressive disorder

Findings from the largest survey ever mounted on the co-occurrence of psychiatric disorders among U.S. adults afford a sharper picture than previously available of major depressive disorder (MDD) in specific population subgroups and of MDD's relationship to alcohol use disorders (AUDs) and other mental health conditions.

3 Oct 2005

Lab-made version of a human protein opens a new research avenue to better understand rheumatoid arthritis

A lab-made version of a human protein alleviates symptoms of both acute and chronic arthritis in mice and could be the basis for a new arthritis drug for people, report scientists from the National Institute of Allergy and Infectious Disease (NIAID), part of the National Institutes of Health (NIH).

3 Oct 2005

Discovery establishes a role for the gene Rsf-1 in ovarian cancer

Johns Hopkins Kimmel Cancer Center researchers have linked alterations in a gene, called Rsf-1, to the most deadly ovarian cancers. The scientists say the discovery is the first to establish a role for the gene in ovarian cancer and may lead to a test that can predict, early on, which patients will develop aggressive disease.

3 Oct 2005

Organosilicon compounds help improve lithium battery technology

With the help of new silicon-based compounds, scientists -- and patients -- are getting a significant new charge out of the tiny lithium batteries used in implantable devices to help treat nervous system and other disorders.

3 Oct 2005

Nicotine has an unusual psychological property that may drive dependence

Associate Professor Athina Markou, Ph.D., who is in the Scripps Research Molecular and Integrative Neurosciences Department at Scripps Research’s La Jolla Campus, and Paul Kenny, Ph.D., a former Research Associate in her laboratory, report in an upcoming issue of the journal Neuropsychopharmacology that nicotine has an unusual psychological property that may drive dependence.

28 Sep 2005