Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Genetically identical Salmonella appear in 2 types, each with an infective advantage

An unusual regulatory mechanism that controls the swimmer/non-swimmer option in genetically identical Salmonella also impacts the bacteria's ability to cause infection.

9 Dec 2011

Positive results from Synta's Ganetespib Phase 2 trial on HER2-positive and triple negative mBC

Synta Pharmaceuticals Corp. - Ganetespib, a potent, second generation Hsp90 inhibitor, has demonstrated clinical activity in heavily pre-treated patients with HER2-positive and triple negative metastatic breast cancer according to Phase 2 clinical trial results presented by researchers from Memorial Sloan-Kettering Cancer Center at the San Antonio Breast Cancer Symposium.

9 Dec 2011

Combination of MEK inhibitors and nilotinib can overcome CML resistance to targeted drug

Cancer Research UK-funded scientists at The Institute of Cancer Research (ICR) have revealed a technique to kill chronic myeloid leukaemia (CML) cells that have stopped responding to a targeted drug, according to research published in Cancer Cell today.

9 Dec 2011

Scientists discover mechanism that controls 'fat switch' in the body

Scientists at Warwick Medical School have made an important discovery about the mechanism controlling the body's 'fat switch', shedding new light on our understanding of how proteins regulate appetite control and insulin secretion.

9 Dec 2011

Mystery of unpleasant tough texture in vegetable oil-cooked hot dogs

In part of an effort to replace animal fat in hot dogs, sausages, hamburgers and other foods with healthier fat, scientists are reporting an advance in solving the mystery of why hot dogs develop an unpleasant tough texture when vegetable oils pinch hit for animal fat. A report on their study appears in ACS' Journal of Agricultural and Food Chemistry.

8 Dec 2011

H. pylori bacterium produces urease to neutralize gastric acid

A research team led by scientists at the Chinese University of Hong Kong is releasing study results this week showing how a bacterium, Helicobacter pylori, that causes more than half of peptic ulcers worldwide and that has been implicated in stomach cancer has managed for eons to turn the acidic environment of the human gut into one in which it can thrive.

8 Dec 2011

New gene editing technique can heal sickle cell patients with their own cells

Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.

8 Dec 2011

Researchers determine planar nets to build self-assembling 3-D structures

Material chemists and engineers would love to figure out how to create self-assembling shells, containers or structures that could be used as tiny drug-carrying containers or to build 3-D sensors and electronic devices.

8 Dec 2011

Animal study offers insights into possible drug targets to improve memory as we age

Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study in the December 7 issue of The Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.

8 Dec 2011

Israeli Nobel Laureate receives AvH's Humboldt Research Award

The Israeli Nobel Laureate Aaron Ciechanover has been named one of the recipients of the Humboldt Research Award of the Alexander von Humboldt Foundation.

8 Dec 2011

Notch inhibitor appears to treat breast cancer

In a novel therapeutic approach to treating breast cancer, Loyola University Medical Center researchers are reporting positive results from a clinical trial of a drug that targets tumor stem cells.

8 Dec 2011

First study to identify molecular mechanism that links inflammation to cancer epigenetics

Johns Hopkins Kimmel Cancer Center scientists report that sharp rises in levels of reactive oxygen molecules, and the inflammation that results, trigger biochemical changes that silence genes in a pattern often seen in cancer cells. The researchers confirmed this gene-silencing effect in mice that develop inflammation-induced colon cancer.

8 Dec 2011

Scientists discover clues to the pancreatic cysts' possible origins

Scientists at Johns Hopkins have surveyed the DNA in four common types of pancreatic cysts, and have determined that each type bears a distinct pattern of gene mutations. Pancreatic cysts are present in about two percent of U.S. adults, and can, in some cases, require surgical removal and microscopic analysis to determine their type and likelihood of turning cancerous.

8 Dec 2011

CRD to conduct review of safety and effectiveness of BMP-2

The Centre for Reviews and Dissemination (CRD) at the University of York is to conduct a major independent review of the effectiveness and safety of bone morphogenetic protein-2 (BMP-2), a product used in spinal surgeries to promote bone growth.

From Medtronic 8 Dec 2011

Positive results from Genentech's pertuzumab plus Herceptin Phase III study on HER2-positive mBC

Genentech, a member of the Roche Group, today announced results from CLEOPATRA, the first randomized Phase III study of the investigational HER2-targeted medicine pertuzumab.

8 Dec 2011

Updated data from Novartis Afinitor plus everolimus Phase III study on advanced breast cancer

Updated results of a Phase III study of Afinitor (everolimus) tablets plus exemestane, a hormonal therapy, show everolimus provided additional time women with advanced breast cancer lived without their disease progressing.

8 Dec 2011

Janssen Biotech, Molecular Partners collaborate to develop DARPins for immunological diseases

Molecular Partners AG today announced that it has entered into a strategic research collaboration and option agreement with Janssen Biotech, Inc. to research, discover and develop DARPin products for the treatment of immunological diseases.

8 Dec 2011

Alzheimer’s vaccine cures memory of mice

A vaccine that slows the progression of Alzheimer’s disease and other types of dementia has been developed by researchers at the University of Sydney’s Brain and Mind Research Institute (BMRI).

7 Dec 2011

Vaccine against Ebola developed

Ebola was first identified in 1976 in Sudan and Zaire, which is now the Democratic Republic of the Congo and Ebola fever kills more than 90% of the people it infects. Ebola is among the most lethal diseases known to humans, according to the World Health Organization.

7 Dec 2011

Next generation personal genomic testing now widely available

The era of widely available next generation personal genomic testing has arrived and with it the ability to quickly and relatively affordably learn the sequence of your entire genome. This would include what is referred to as the "exome," your complete set of protein-coding sequences.

7 Dec 2011

Protein News and Research

Further Reading

Genetically identical Salmonella appear in 2 types, each with an infective advantage

Positive results from Synta's Ganetespib Phase 2 trial on HER2-positive and triple negative mBC

Combination of MEK inhibitors and nilotinib can overcome CML resistance to targeted drug

Scientists discover mechanism that controls 'fat switch' in the body

Mystery of unpleasant tough texture in vegetable oil-cooked hot dogs

H. pylori bacterium produces urease to neutralize gastric acid

New gene editing technique can heal sickle cell patients with their own cells

Researchers determine planar nets to build self-assembling 3-D structures

Animal study offers insights into possible drug targets to improve memory as we age

Israeli Nobel Laureate receives AvH's Humboldt Research Award

Notch inhibitor appears to treat breast cancer

First study to identify molecular mechanism that links inflammation to cancer epigenetics

Scientists discover clues to the pancreatic cysts' possible origins

CRD to conduct review of safety and effectiveness of BMP-2

Positive results from Genentech's pertuzumab plus Herceptin Phase III study on HER2-positive mBC

Updated data from Novartis Afinitor plus everolimus Phase III study on advanced breast cancer

Janssen Biotech, Molecular Partners collaborate to develop DARPins for immunological diseases

Alzheimer’s vaccine cures memory of mice

Vaccine against Ebola developed

Next generation personal genomic testing now widely available

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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