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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Scientists discover how MRP-14 gene generates dangerous clots that could trigger heart attack

Right now, options are limited for preventing heart attacks. However, the day may come when treatments target the heart attack gene, myeloid related protein-14 (MRP-14, also known as S100A9) and defang its ability to produce heart attack-inducing blood clots, a process referred to as thrombosis.

2 Apr 2014

New research links spread of colon cancer to PLAC8 protein

New research at Washington University School of Medicine in St. Louis and Vanderbilt University Medical Center in Nashville has implicated a poorly understood protein called PLAC8 in the spread of colon cancer.

2 Apr 2014

Cedars-Sinai earns grant to conduct clinical trial of gene therapy product for patients with Lou Gehrig's disease

The Cedars-Sinai Regenerative Medicine Institute has received a $2.5 million grant from the Department of Defense to conduct animal studies that, if successful, could provide the basis for a clinical trial of a gene therapy product for patients with Lou Gehrig's disease, also called amyotrophic lateral sclerosis, or ALS.

2 Apr 2014

High levels of GDNF protein could help body resist weight gain despite high-fat diet

More than one-third of people in the US are obese. Obesity and its related health problems-including high blood pressure, high cholesterol, diabetes, insulin resistance, and belly fat-affect so many, yet effective treatments are very few.

2 Apr 2014

Study shows link between breast-feeding and risk of child developing obesity

Many studies have focused on the influence of breast-feeding on child health. From analysis of data from the ELANCE cohort, Marie Fran-oise Rolland-Cachera, former researcher at Inserm and her co-workers in the Nutritional Epidemiology Research Team (EREN) have shown that breast-feeding has a protective effect on the risk of obesity at 20 years of age.

2 Apr 2014

Molecular function of "hairless" gene may contribute to pathogenesis of atrichia with papular lesions

It's not a hair-brained idea: A new research report appearing in the April 2014 issue of The FASEB Journal explains why people with a rare balding condition called "atrichia with papular lesions" lose their hair, and it identifies a strategy for reversing this hair loss.

1 Apr 2014

Discovery could lead to new therapies for people with celiac disease

Researchers at McMaster University have discovered a key molecule that could lead to new therapies for people with celiac disease, an often painful and currently untreatable autoimmune disorder.

1 Apr 2014

FORMA Therapeutics signs second strategic collaboration and option agreement with Celgene

FORMA Therapeutics, an innovative R&D organization in pursuit of ground-breaking medicines in oncology and other therapeutic areas, today announced a second strategic collaboration and option agreement with Celgene Corporation, a leader in addressing high unmet medical needs.

1 Apr 2014

Researchers identify possible mechanism for re-growing damaged nerve fibres in central nervous system

A new discovery suggests it could one day be possible to chemically reprogram and repair damaged nerves after spinal cord injury or brain trauma.

1 Apr 2014

Trinean, Sony DADC sign manufacturing and supply agreement to develop microfluidic disposables

Trinean, the leading provider of microfluidic spectrophotometry platforms, today announced that it entered into a manufacturing and supply agreement with Sony DADC for the production of microfluidic disposables fit for storage and micro-cuvette analysis of droplet-sized biological samples.

1 Apr 2014

New research implicates that RNA processing is central to ALS disease process

In work supported by The ALS Association, researchers have discovered a new ALS-causing gene and have linked its function to that of another prominent disease gene. The study was published in the journal Nature Neuroscience.

1 Apr 2014

Research uncovers link between diet and blood cell markers of heart attack associated inflammation

New research further illuminates the heart-healthy benefits of the Mediterranean diet, tying the eating plan to lower levels of platelets and white blood cells, two markers of inflammation. Inflammation has an association with greater risk of heart attack and stroke.

1 Apr 2014

Experimental anticancer compound appears to reverse behaviors associated with schizophrenia

Johns Hopkins researchers say that an experimental anticancer compound appears to have reversed behaviors associated with schizophrenia and restored some lost brain cell function in adolescent mice with a rodent version of the devastating mental illness.

1 Apr 2014

S. pneumoniae is commonest cause of paediatric CAP

Streptococcus pneumoniae is the predominant cause of community-acquired pneumonia among children in Belgium, with non-vaccine serotypes accounting for the majority of cases, a Belgian study shows.

31 Mar 2014

CytRx’s aldoxorubicin receives European orphan medicinal product designation for treatment of advanced soft tissue sarcomas

CytRx Corporation, a biopharmaceutical research and development company specializing in oncology, today announced that aldoxorubicin has received orphan medicinal product designation from the European Commission for the treatment of advanced soft tissue sarcomas. The designation is to encourage the development of drugs which may provide significant benefit to patients suffering from rare diseases.

31 Mar 2014

Venaxis files 510(k) premarket submission with FDA for APPY1 Test

Venaxis, Inc., an in vitro diagnostic company focused on obtaining FDA clearance for and commercializing its CE Marked APPY1™ Test, a rapid, multiple biomarker-based index assay for identifying patients that are at low risk for appendicitis, today announced that it has filed a 510(k) premarket submission for the APPY1 Test. Venaxis has requested concurrent de novo determination and 510(k) clearance from the U.S. Food and Drug Administration.

31 Mar 2014

Amgen reports positive findings from AMG 145 Phase 3 studies in patients at risk for cardiovascular disease

Amgen (NASDAQ: AMGN) today announced new detailed data from three Phase 3 studies that showed treatment with its novel investigational cholesterol-lowering medication, evolocumab (AMG 145), resulted in a statistically significant reduction of 55-66 percent in low-density lipoprotein cholesterol (LDL-C) compared to placebo in patients with high cholesterol.

31 Mar 2014

Genetic markers could help predict heart attack in patients with heart disease

Researchers at the Intermountain Medical Center Heart Institute in Salt Lake City have identified a biological process that may help physicians predict when someone with heart disease is likely to have a heart attack in the near future.

31 Mar 2014

SEATTLE II study confirms safety and efficacy of thrombolytic therapy for acute PE

EKOS Corporation, a BTG International group company, notes the presentation of the results of the SEATTLE II trial this afternoon at ACC.14, the 63rd Annual Scientific Session and Exposition of the American College of Cardiology in Washington, DC in the United States.

31 Mar 2014

Researchers develop new responsive coating for implants used in surgery

A research group at Uppsala University, Sweden has developed a new responsive coating for implants used in surgery to improve their integration into bone and to prevent rejection. Neutron scattering experiments at the Institut Laue-Langevin (ILL) in Grenoble, France have shown how a protein that promotes bone growth binds to this surface and can be released in a controlled way.

31 Mar 2014

Protein News and Research

Further Reading

Scientists discover how MRP-14 gene generates dangerous clots that could trigger heart attack

New research links spread of colon cancer to PLAC8 protein

Cedars-Sinai earns grant to conduct clinical trial of gene therapy product for patients with Lou Gehrig's disease

High levels of GDNF protein could help body resist weight gain despite high-fat diet

Study shows link between breast-feeding and risk of child developing obesity

Molecular function of "hairless" gene may contribute to pathogenesis of atrichia with papular lesions

Discovery could lead to new therapies for people with celiac disease

FORMA Therapeutics signs second strategic collaboration and option agreement with Celgene

Researchers identify possible mechanism for re-growing damaged nerve fibres in central nervous system

Trinean, Sony DADC sign manufacturing and supply agreement to develop microfluidic disposables

New research implicates that RNA processing is central to ALS disease process

Research uncovers link between diet and blood cell markers of heart attack associated inflammation

Experimental anticancer compound appears to reverse behaviors associated with schizophrenia

S. pneumoniae is commonest cause of paediatric CAP

CytRx’s aldoxorubicin receives European orphan medicinal product designation for treatment of advanced soft tissue sarcomas

Venaxis files 510(k) premarket submission with FDA for APPY1 Test

Amgen reports positive findings from AMG 145 Phase 3 studies in patients at risk for cardiovascular disease

Genetic markers could help predict heart attack in patients with heart disease

SEATTLE II study confirms safety and efficacy of thrombolytic therapy for acute PE

Researchers develop new responsive coating for implants used in surgery

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